Tryptophan 5-hydroxylase 2 (TPH2) antibody

Principal name

Tryptophan 5-hydroxylase 2 (TPH2) antibody

Alternative names for Tryptophan 5-hydroxylase 2 (TPH2) antibody

Tryptophan 5-monooxygenase 2, Neuronal tryptophan hydroxylase, NTPH

SwissProt ID

Q0EAB8 (Horse), Q8CGU9 (Rat), Q8CGV2 (Mouse), Q8IWU9 (Human)

Gene ID

121278 (TPH2), 317675 (Tph2)

Available reactivities

Bov (Bovine), Can (Canine), Chk (Chicken), Hu (Human), Ms (Mouse), Rt (Rat), Ze (Zebrafish), Por (Porcine), Rb (Rabbit), Eq (Equine)

Available hosts

Rabbit, Goat

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), Flow Cytometry (F)

Background of Tryptophan 5-hydroxylase 2 (TPH2) antibody

Tryptophan hydroxylase (TPH; EC 1.14.16.4) is the rate-limiting enzyme in the synthesis of serotonin (5-hydroxytryptamine, or 5HT). 5HT is causally involved in numerous central nervous activities, and it has several functions in peripheral tissues, including the maintence of vascular tone and gut motility. This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. The human genome contains two related tryptophan hydroxylases, one on chromosome 11p15-p14 and one on chromosome 12q21. This gene is expressed predomintly in the brain stem. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by the mouse ortholog. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additiol publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-1805 AY098914.1 1-1805 1806-2360 AC090109.15 122981-123535

General readings

Mari M, Bujny MV, Zeuschner D, Geerts WJ, Griffith J, Petersen CM, Cullen PJ, Klumperman J, Geuze HJ, SNX1 defines an early endosomal recycling exit for sortilin and mannose 6-phosphate receptors. Traffic (Copenhagen, Denmark) 2008 Mar 9 (3): 380-93.

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Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Tryptophan 5-hydroxylase 2 (TPH2)

  Purified recombinant protein of Homo sapiens tryptophan hydroxylase 2 (TPH2)  
Tryptophan 5-hydroxylase 2 (TPH2) Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €748.00
  OriGene Technologies, Inc.

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