TSC1 / Hamartin antibody
Principal name
TSC1 / Hamartin antibody
Alternative names for TSC1 / Hamartin antibody
KIAA0243, TSC, Tuberous sclerosis 1 protein
Ncbi ID
NP_000359.1, 9606, AAI67824.1, AAC51674, NM_021854, NM_001162427, NM_001162426
Available reactivities
Available hosts
Available applications
Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), Dot blot (Dot)
Background of TSC1 / Hamartin antibody
Tuberous sclerosis complex (TSC) is an autosomal dominant tumor syndrome caused by mutations in either of the TSC1 or TSC2 tumor suppressor genes. The products of these genes form a protein complex that indirectly decreases the signaling of the mammalian Target of Rapamycin (TOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors (reviewed in 1,2). TOR activity is stimulated by Rheb, a member of the Ras superfamily of G-proteins, when the GTP/GDP ratio bound to Rheb is high (3). Immunoprecipitated TSC1/TSC2 has been shown to stimulate Rheb GTPase activity in vitro (4), suggesting that the TSC1/TSC2 decreases the ability of Rheb to stimulate TOR activity. This is supported by experiments showing overexpression of TSC1 and TSC2 results in a significant decrease in the GTP/GDP ratio bound to Rheb and the inhibition of cell growth (4,5). A shorter 40 kDa isoform of TSC1 has been shown to exist but its function is unknown.






























- Quick-Filters:
- Highly Validated (2)
Primary Antibodies
Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
---|---|---|---|---|---|---|---|
TA801949 | TSC1 / Hamartin antibody |
||||||
TSC1 mouse monoclonal antibody, clone OTI3A2 (formerly 3A2) | |||||||
![]() |
Mouse | IgG2a | OTI3A2 | Purified | Hu | P, WB |
0.1 ml /
€350.00
|
OriGene Technologies, Inc. | |||||||
![]() |
Highly validated antibody! |
||||||
TA801951 | TSC1 / Hamartin antibody |
||||||
TSC1 mouse monoclonal antibody, clone OTI5A8 (formerly 5A8) | |||||||
![]() |
Mouse | IgG2b | OTI5A8 | Purified | Hu | P, WB |
0.1 ml /
€350.00
|
OriGene Technologies, Inc. | |||||||
![]() |
Highly validated antibody! |
||||||
TA302506 | TSC1 / Hamartin (Isoform 1) antibody |
||||||
Goat Polyclonal Antibody against Hamartin / TSC1 (isoform 1) | |||||||
![]() |
Goat | Aff - Purified | Can, Hu, Ms, Rt | P, WB |
0.1 mg /
€360.00
|
||
OriGene Technologies, Inc. | |||||||
TA306217 | TSC1 / Hamartin (C-term) antibody |
||||||
Rabbit Polyclonal TSC1 Antibody | |||||||
![]() |
Rabbit | IgG | Aff - Purified | Hu, Ms | E, WB |
0.1 mg /
€371.00
|
|
OriGene Technologies, Inc. | |||||||
TA306218 | TSC1 / Hamartin (Center) antibody |
||||||
Rabbit Polyclonal TSC1 Antibody | |||||||
![]() |
Rabbit | IgG | Aff - Purified | Hu, Ms, Rt | E, ICC/IF, WB |
0.1 mg /
€371.00
|
|
OriGene Technologies, Inc. | |||||||
![]() |
|||||||
TA347864 | TSC1 / Hamartin antibody |
||||||
Rabbit Polyclonal Anti-TSC1 Antibody | |||||||
![]() |
Rabbit | IgG | Purified | Hu, Ms, Rt | WB |
0.1 mg /
€335.00
|
|
OriGene Technologies, Inc. | |||||||
TA590017 | TSC1 / Hamartin antibody |
||||||
Rabbit Polyclonal TSC1 Antibody | |||||||
![]() |
Rabbit | IgG | Purified | Hu | E, WB |
0.1 mg /
€409.00
|
|
OriGene Technologies, Inc. | |||||||
![]() |
|||||||
TA801952 | TSC1 / Hamartin antibody |
||||||
TSC1 mouse monoclonal antibody, clone OTI2G3 (formerly 2G3) | |||||||
![]() |
Mouse | IgG1 | OTI2G3 | Purified | Hu | WB |
0.1 ml /
€350.00
|
OriGene Technologies, Inc. | |||||||
TA802012 | TSC1 / Hamartin antibody |
||||||
TSC1 mouse monoclonal antibody, clone OTI2B2 (formerly 2B2) | |||||||
![]() |
Mouse | IgG2a | OTI2B2 | Purified | Hu | WB |
0.1 ml /
€350.00
|
OriGene Technologies, Inc. | |||||||
TA802093 | TSC1 / Hamartin antibody |
||||||
TSC1 mouse monoclonal antibody, clone OTI5A7 (formerly 5A7) | |||||||
![]() |
Mouse | IgG2a | OTI5A7 | Purified | Hu | WB |
0.1 ml /
€350.00
|
OriGene Technologies, Inc. | |||||||
AP07383PU-N | TSC1 / Hamartin antibody |
||||||
![]() |
Rabbit | Aff - Purified | Hu, Ms | P, WB |
50 µg /
€380.00
|
||
Acris Antibodies GmbH | |||||||
![]() |
|||||||
AP07800PU-N | TSC1 / Hamartin antibody |
||||||
![]() |
Rabbit | Aff - Purified | Hu, Ms, Rt | ICC/IF, P, WB |
50 µg /
€380.00
|
||
Acris Antibodies GmbH | |||||||
![]() |
|||||||
AP12886PU-N | TSC1 / Hamartin pSer505 antibody |
||||||
![]() |
Rabbit | Ig | Aff - Purified | Hu |
0.4 ml /
€370.00
|
||
Acris Antibodies GmbH | |||||||
SP2163P | TSC1 / Hamartin antibody |
||||||
![]() |
Rabbit | Aff - Purified | Hu, Ms, Rt | ICC/IF, WB |
0.1 mg /
€380.00
|
||
Acris Antibodies GmbH |
CRISPR
Catalog No. | Species | Donor Vector | |
---|---|---|---|
KN213332 | TSC1 - human gene knockout kit via CRISPR |
||
![]() |
Human | GFP-Puro |
1 kit /
€1,290.00
|
OriGene Technologies, Inc. | |||
KN213332BN | TSC1 - human gene knockout kit via CRISPR |
||
![]() |
Human | mBFP-Neo |
1 kit /
€1,290.00
|
OriGene Technologies, Inc. | |||
KN213332LP | TSC1 - human gene knockout kit via CRISPR |
||
![]() |
Human | Luciferase-Puro |
1 kit /
€1,290.00
|
OriGene Technologies, Inc. | |||
KN213332RB | TSC1 - human gene knockout kit via CRISPR |
||
![]() |
Human | RFP-BSD |
1 kit /
€1,290.00
|
OriGene Technologies, Inc. |
Human Lenti ORF Particles
Catalog No. | ||
---|---|---|
RC228646L2V | Lenti ORF particles, TSC1 (mGFP-tagged)-Human tuberous sclerosis 1 (TSC1), transcript variant 3, 200 uL, >10^7 TU/mL |
|
![]() |
200 µl /
€2,380.00
|
|
OriGene Technologies, Inc. | ||
RC228640L2V | Lenti ORF particles, TSC1 (mGFP-tagged)-Human tuberous sclerosis 1 (TSC1), transcript variant 4, 200 uL, >10^7 TU/mL |
|
![]() |
200 µl /
€2,297.00
|
|
OriGene Technologies, Inc. | ||