TSEN2 / SEN2 antibody

Principal name

TSEN2 / SEN2 antibody

Alternative names for TSEN2 / SEN2 antibody

tRNA-splicing endonuclease subunit Sen2, tRNA-intron endonuclease Sen2

SwissProt ID

Q5M954 (Rat), Q5ZIN2 (Chick), Q6P7W5 (Mouse), Q8NCE0 (Human)

Gene ID

80746 (TSEN2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)

Background of TSEN2 / SEN2 antibody

The tRNA-splicing endonuclease complex is responsible for identifying and cleaving pre-tRNA at both 5’ and 3’ splice sites, thereby releasing introns and free tRNA molecules with 2',3' cyclic phosphates and 5'-OH termini. In addition to its role in pre-tRNA splicing, the heterotetrameric endonuclease complex participates in mRNA processing and, via its association with pre-mRNA processing factors, is thought to link pre-tRNA and pre-mRNA splicing events. TSEN2 (tRNA-splicing endonuclease subunit Sen2), also known as tRNA-intron endonuclease Sen2, is a 465 amino acid nuclear protein that constitutes one of the two catalytic subunits of the tRNA-splicing endonuclease complex. There are three isoforms of TSEN2 that are produced as a result of alternative splicing events. Isoform 1 seems to carry the active site for 5’-splice site cleavage. Defects in the gene encoding TSEN2 are the cause of pontocerebellar hypoplasia type 2B, which is characterized by progressive microencephaly with epilepsy, extrapyramidal dyskinesia and chorea without spinal cord findings.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TSEN2 / SEN2 antibody

TSEN2 / SEN2 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

TSEN2 / SEN2 antibody

Immunofluorescence of purified MaxPab antibody to TSEN2 on HeLa cell. [antibody concentration 10 ug/ml] Mouse Purified Hu E(detection), ICC/IF, WB
50 µg / €370.00
  Abnova Taiwan Corp.

TSEN2 / SEN2 antibody

Immunohistochemistry-Paraffin: TSEN2 Antibody [NBP1-81140] - Immunohistochemical staining of human skeletal muscle shows moderate cytoplasmic positivity in myocytes. Rabbit IgG Aff - Purified Hu ICC/IF, P
0.1 ml / €500.00
  Novus Biologicals Inc.

TSEN2 / SEN2 antibody

Immunohistochemistry-Paraffin: TSEN2 Antibody [NBP1-81141] - Immunohistochemical staining of human cerebellum shows distinct nuclear positivity in purkinje cells. Rabbit IgG Aff - Purified Hu ICC/IF, P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

TSEN2 / SEN2 antibody

Immunohistochemistry-Paraffin: TSEN2 Antibody [NBP1-81142] Immunohistochemical staining of human stomach shows strong cytoplasmic positivity in parietal cells. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

TSEN2 / SEN2 (transcript variant 1)

TSEN2 / SEN2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

TSEN2 / SEN2 (transcript variant 2)

TSEN2 / SEN2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

TSEN2 / SEN2

TSEN2 / SEN2 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

TSEN2 / SEN2

TSEN2 / SEN2 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

TSEN2 / SEN2

TSEN2 / SEN2 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

TSEN2 / SEN2

TSEN2 / SEN2 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

TSEN2 293T Cell Transient Overexpression Lysate(Denatured)

TSEN2 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

TSEN2 overexpression lysate

TSEN2 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

TSEN2 overexpression lysate

TSEN2 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

14 Item(s)

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