TSLP antibody

Principal name

TSLP antibody

Alternative names for TSLP antibody

Thymic stromal lymphopoietin, Thymic stroma-derived lymphopoietin

SwissProt ID

Q969D9 (Human), Q9JIE6 (Mouse)

Gene ID

85480 (TSLP), 53603 (Tslp)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Eq (Equine)

Available hosts

Rabbit, Rat, Mouse

Available applications

Paraffin Sections (P), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Frozen Sections (C), ELISA (capture) (E(capture)), Flow Cytometry (F)

Background of TSLP antibody

The 15B11.3 monoclonal antibody reacts with human thymic stromal lymphopoietin (TSLP). TSLP is an IL-7-like cytokine derived from epithelial cells, which strongly activates dendritic cells (DC). TSLP can replace the activity of IL-7 in supporting the development of B cells in vitro it promotes the proliferation and differentiation of committed B220(+) B cell progenitors. TSLP prevents cell death by apoptosis and stimulates growth of the human acute myeloid leukemia cell line MUTZ-3. This effect is neutralized by antibodies directed against IL-7. The TSLP receptor has been shown to be a member of the hematopoietin receptor superfamily. High affinity binding sites require the presence of the alpha chain of the IL-7 receptor (CD127). The receptor complex does not involve the common gamma chain (CD132), a signal-transducing component of various cytokine receptors, including receptors for IL-4, IL-7, IL-9, IL-13, and IL-15. Recently TSLP has been found expressed by keratinocytes of atopic dermatitis TSLP expression is also associated with Langerhans cell migration and activation in situ. TSLP expressed within thymus and peripheral lymphoid and non-lymphoid tissues regulates DC-mediated central tolerance, peripheral T cell homeostasis, and inflammatory Th2 responses. DCs activated by TSLP can prime nave CD4 T cells to differentiate into T helper type 2 cells that produce high levels of TNF-alpha, but no IL-10. This priming for Th2 differentiation is dependent upon TSLP-mediated upregulation of OX40L by DCs.

General readings

Datta A.,et al. (2013) J. Immunol. 191 (9), 4867-4879

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TSLP antibody

Formalin-Fixed, Paraffin-Embedded Human Sections prostate stained with TSLP Antibody Cat.-No AP01155PU at 0.125 µg/ml with an overnight incubation at 4°C.  An HRP-labeled polymer detection system was used with a DAB chromogen.  Heat induced antigen retrieval with a pH 6.0 sodium citrate buffer is recommended. Tissue samples were provided by the Cooperative Human Tissue Network, which is funded by the National Cancer Institute. Rabbit Aff - Purified Hu E, P, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

TSLP antibody

Formalin-Fixed, Paraffin-Embedded Human Sections prostate stained with TSLP Antibody Cat.-No AP01155PU at 0.125 µg/ml with an overnight incubation at 4°C.  An HRP-labeled polymer detection system was used with a DAB chromogen.  Heat induced antigen retrieval with a pH 6.0 sodium citrate buffer is recommended. Tissue samples were provided by the Cooperative Human Tissue Network, which is funded by the National Cancer Institute. Rabbit Aff - Purified Hu E, P, WB
50 µg / €230.00
  Acris Antibodies GmbH

TSLP antibody

Human Prostate (formalin-fixed, paraffin-embedded) stained with TSLP antibody AP22662PU-N at 2.5 µg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit Purified Hu, Ms E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

TSLP (C-term) antibody

Western blot analysis of TSLP in Jurkat cell lysate with TSLP antibody at (A) 1 and (B) 2 ug/ml. Rabbit IgG Aff - Purified Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TSLP (Center) antibody

Western blot analysis of TSLP in A-20 cell lysate with TSLP antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml. Rabbit IgG Aff - Purified Hu, Ms E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TSLP antibody

Western blot analysis of TSLP in A-20 cell lysate with TSLP antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml. Rabbit IgG Aff - Purified Ms, Rt E, ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TSLP antibody

Standard curve of Human TSLP ELISA. Mouse eBio15B11.3 (15B11.3 ) Purified Hu E
50 µg / €120.00
  OriGene Technologies, Inc.

TSLP antibody

Predicted band size: 18 kDa . Positive control: Jurkat cell lysate. Recommended dilution: 1/500-2000. (Gel: 16+12+10%SDS-PAGE Lysate: 40 ug per lane Primary antibody: 1/850 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 2 minutes) Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TSLP antibody

To detect hTSLP by sandwich ELISA (using 100 ul/well antibody solution) a concentration of 0.5 - 2.0 ug/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with Biotinylated Anti-Human TSLP  as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant hTSLP. Rabbit IgG Purified Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TSLP antibody

TSLP Rabbit Biotin Hu E, WB
50 µg / €340.00
  Acris Antibodies GmbH

TSLP antibody

TSLP Rabbit Biotin Hu E, WB
25 µg / €230.00
  Acris Antibodies GmbH

TSLP antibody

Figure 1. Staining TSLP in Thymus by Immunohistochemistry using Formalin-Fixed Paraffin-Embedded (FFPE) tissue. Rabbit Aff - Purified Hu P, WB
50 µg / €470.00
  Acris Antibodies GmbH

TSLP antibody

Mouse Liver (formalin-fixed, paraffin-embedded) stained with TSLP antibody AP22809PU-N followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit Purified Ms, Rt E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

TSLP Control Peptide

TSLP
50 µg / €160.00
  Acris Antibodies GmbH

TSLP Control Peptide

TSLP
50 µg / €160.00
  Acris Antibodies GmbH

TSLP Control Peptide

TSLP
50 µg / €160.00
  Acris Antibodies GmbH

TSLP (C-term) antibody

TSLP Antibody (C-term) (AP54374PU-N) western blot analysis in Jurkat cell line lysates (35 µg/lane). This demonstrates the TSLP antibody detected the TSLP protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

TSLP antibody

TSLP Rat IgG2 5G29 Purified Ms WB
0.1 mg / €440.00
  Acris Antibodies GmbH

TSLP antibody

Immunohistochemistry of TSLP in human brain tissue with TSLP polyclonal antibody ( Cat # PAB13434 ) at 2.5 µg/ml. Rabbit Hu P, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

TSLP antibody

Immunohistochemistry of TSLP in human brain tissue with TSLP polyclonal antibody ( Cat # PAB13435 ) at 2.5 µg/ml. Rabbit Hu, Ms P, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

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