TSPO / BZRP antibody

Principal name

TSPO / BZRP antibody

Alternative names for TSPO / BZRP antibody

MBR, Translocator protein, Peripheral-type benzodiazepine receptor, PKBS, PBR, Mitochondrial benzodiazepine receptor

SwissProt ID

P16257 (Rat), P30535 (Bovin), P30536 (Human), P50637 (Mouse), Q6UN27 (Pig), Q9GMC9 (Sheep)

Gene ID

706 (TSPO), 12257 (Tspo), 24230

Available reactivities

Hu (Human), Mky (Monkey), Prim (Primate), Rb (Rabbit), Bear, Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Goat, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Paraffin Sections (P)

Background of TSPO / BZRP antibody

18-kDa Translocator Protein (TSPO) is one of the subunits of Peripheral-type benzodiazepine receptors (PBR), 30-kDa TSPO and 32-kDa TSPO are the other two subunits (1). 18-kDa TSPO, located at human chromosome 22q13.3 (2), binds isoquinone carboamide derivatives and is involved in a variety of host defense responses, developmental processes and mitochondrial functions. Specifically, it plays a major role in steroidogenesis, controlling cholesterol mitochondrial transport, apoptosis and host-defense response to disease and injury (3). Its ligands (such as porphyrins and diazepine-binding inhibitor) have been shown to control cell differentiation and proliferation (4). Furthermore, their binding capacity was enhanced in some malignant tumors and therefore, PBR is a potential drug target for cancer therapy (5).
PBR functions also include regulation of voltage-dependent calcium channels, responses to stress and microglia activation (6). PBR is densely populated in acute stress and sparsely populated in chronic stress (4). In blood cells, PBR is implicated in phagocytosis, secretion of interleukin-2, interleukin-3, and immunoglobulin A (IgA). In blood vessel walls, PBR takes part in respsonses to trauma such as ischemia (6). PBR can be found in platelets, erythrocytes, lymphocytes, mononuclear cells, endothelium, striated cardiac muscle, vascular smooth muscles and mast cells. 18-kDa TSPO is approximately an 18-kDa protein (160 amino acids).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TSPO / BZRP (C-term) antibody

  Goat Anti-PBR (mouse) Antibody  
TA305904 (0.2ug/ml) staining of Mouse Spleen lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TSPO / BZRP (C-term) antibody

Human Squamous Epithelium: Formalin-Fixed, Paraffin-Embedded (FFPE) Goat Purified Hu, Ms, Rt E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

TSPO / BZRP (C-term) antibody

  Goat Polyclonal Antibody against TSPO  
TA303138 (0.1µg/ml) staining of Human Brain lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Hu P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TSPO / BZRP antibody

  Rabbit polyclonal anti-TSPO/PBR (Peripheral-type Benzodiazepine Receptor) antibody  
Western blot analysis of PBR expression in rat kidney tissue lysate. Rabbit Purified Hu, Ms, Rt P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TSPO / BZRP Control Peptide

TSPO / BZRP
0.1 mg / €250.00
  Acris Antibodies GmbH

TSPO / BZRP antibody

Western blot of Peripheral Diazapine Recpetor antibody (AP10363PU-N at 1/500 dilution) Rabbit IgG Aff - Purified Hu E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

TSPO / BZRP (156-169) antibody

Human Colon (formalin-fixed, paraffin-embedded) stained with TSPO antibody AP22540PU-N at 2.5 µg/ml followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Goat Aff - Purified Bear, Hu, Mky, Prim, Rb E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

TSPO - human gene knockout kit via CRISPR

TSPO - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

TSPO - human gene knockout kit via CRISPR

TSPO - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

TSPO - human gene knockout kit via CRISPR

TSPO - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Tspo - mouse gene knockout kit via CRISPR

Tspo - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Tspo - mouse gene knockout kit via CRISPR

Tspo - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Tspo - mouse gene knockout kit via CRISPR

Tspo - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Tspo - mouse gene knockout kit via CRISPR

Tspo - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

TSPO / BZRP (transcript variant PBR)

  Recombinant protein of human translocator protein (18kDa) (TSPO), transcript variant PBR  
TSPO / BZRP Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

Lysates (Knockout)

Catalog No.    

TSPO-knockout Cell lysate

TSPO-knockout Cell lysate  
0.1 mg / €495.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, TSPO (mGFP-tagged) - Human translocator protein (18kDa) (TSPO), transcript variant PBR, 200 uL, >10^7 TU/mL

Lenti ORF particles, TSPO (mGFP-tagged) - Human translocator protein (18kDa) (TSPO), transcript variant PBR, 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, TSPO (Myc-DDK tagged) - Human translocator protein (18kDa) (TSPO), transcript variant PBR , 200 uL, >10^7 TU/mL

Lenti ORF particles, TSPO (Myc-DDK tagged) - Human translocator protein (18kDa) (TSPO), transcript variant PBR , 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Tspo (GFP-tagged) - Mouse translocator protein (Tspo), 200 uL, >10^7 TU/mL

Lenti ORF particles, Tspo (GFP-tagged) - Mouse translocator protein (Tspo), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Tspo (Myc-DDK-tagged) - Mouse translocator protein (Tspo), 200 uL, >10^7 TU/mL

Lenti ORF particles, Tspo (Myc-DDK-tagged) - Mouse translocator protein (Tspo), 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

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