TSPO / BZRP antibody

Principal name

TSPO / BZRP antibody

Alternative names for TSPO / BZRP antibody

MBR, Translocator protein, Peripheral-type benzodiazepine receptor, PKBS, PBR, Mitochondrial benzodiazepine receptor

SwissProt ID

P16257 (Rat), P30535 (Bovin), P30536 (Human), P50637 (Mouse), Q6UN27 (Pig), Q9GMC9 (Sheep)

Gene ID

706 (TSPO), 12257 (Tspo)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Goat, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Frozen Sections (C), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP)

Background of TSPO / BZRP antibody

18-kDa Translocator Protein (TSPO) is one of the subunits of Peripheral-type benzodiazepine receptors (PBR), 30-kDa TSPO and 32-kDa TSPO are the other two subunits (1). 18-kDa TSPO, located at human chromosome 22q13.3 (2), binds isoquinone carboamide derivatives and is involved in a variety of host defense responses, developmental processes and mitochondrial functions. Specifically, it plays a major role in steroidogenesis, controlling cholesterol mitochondrial transport, apoptosis and host-defense response to disease and injury (3). Its ligands (such as porphyrins and diazepine-binding inhibitor) have been shown to control cell differentiation and proliferation (4). Furthermore, their binding capacity was enhanced in some malignant tumors and therefore, PBR is a potential drug target for cancer therapy (5).
PBR functions also include regulation of voltage-dependent calcium channels, responses to stress and microglia activation (6). PBR is densely populated in acute stress and sparsely populated in chronic stress (4). In blood cells, PBR is implicated in phagocytosis, secretion of interleukin-2, interleukin-3, and immunoglobulin A (IgA). In blood vessel walls, PBR takes part in respsonses to trauma such as ischemia (6). PBR can be found in platelets, erythrocytes, lymphocytes, mononuclear cells, endothelium, striated cardiac muscle, vascular smooth muscles and mast cells. 18-kDa TSPO is approximately an 18-kDa protein (160 amino acids).

General readings

Pretner E, Amri H, Li W, Brown R, Lin CS, Makariou E, Defeudis FV, Drieu K, Papadopoulos V. Cancer-related overexpression of the peripheral-type benzodiazepine receptor and cytostatic anticancer effects of Ginkgo biloba extract (EGb 761). Anticancer Res. 2006 Jan-Feb;26(1A):9-22. PMID: 16475673

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TSPO / BZRP (C-term) antibody

TA305904 (0.2ug/ml) staining of Mouse Spleen lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TSPO / BZRP (C-term) antibody

Human Squamous Epithelium: Formalin-Fixed, Paraffin-Embedded (FFPE) Goat Purified Hu, Ms, Rt E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

TSPO / BZRP (C-term) antibody

TA303138 (0.1µg/ml) staining of Human Brain lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Hu P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TSPO / BZRP antibody

Western blot analysis of PBR expression in rat kidney tissue lysate. Rabbit Purified Hu, Ms, Rt P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TSPO / BZRP Control Peptide

TSPO / BZRP
0.1 mg / €250.00
  Acris Antibodies GmbH

TSPO / BZRP antibody

Western blot of Peripheral Diazapine Recpetor antibody (AP10363PU-N at 1/500 dilution) Rabbit IgG Aff - Purified Hu E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

TSPO / BZRP (156-169) antibody

Human Colon (formalin-fixed, paraffin-embedded) stained with TSPO antibody AP22540PU-N at 2.5 µg/ml followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Goat Aff - Purified Bear, Hu, Mky, Prim, Rb E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

TSPO / BZRP antibody

TSPO / BZRP Mouse Serum Hu E
50 µl / €290.00
  Abnova Taiwan Corp.

TSPO / BZRP antibody

Immunofluorescence of purified MaxPab antibody to BZRP on HeLa cell. [antibody concentration 10 ug/ml] Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

TSPO / BZRP antibody

Western Blot analysis of TSPO expression in transfected 293T cell line (H00000706-T01) by TSPO MaxPab polyclonal antibody.

Lane 1: TSPO transfected lysate(18.80 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

TSPO / BZRP antibody

Detection limit for recombinant GST tagged BZRP is approximately 10ng/ml as a capture antibody. Mouse IgG1 3D8-B2 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

TSPO / BZRP antibody

TSPO polyclonal antibody ( Cat # PAB7095 ) ( 0.1 µg/ml ) staining of human brain lysate ( 35 µg protein in RIPA buffer ) . Primary incubation was 1 hour. Detected by chemiluminescence. Goat Hu E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

TSPO / BZRP antibody

Western blot analysis of PBR expression in HEK293T (A); SP2/0 (B); PC12 (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

TSPO / BZRP antibody

Western blot analysis of PBR expression in HEK293T (A); SP2/0 (B); PC12 (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

TSPO / BZRP antibody

Western blot analysis of PBR expression in HEK293T (A); SP2/0 (B); PC12 (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

TSPO / BZRP antibody

Immunohistochemistry-Paraffin: PBR Antibody [NB100-41398] - IHC staining (2.5µg/ml) of paraffin embedded Human Colon. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Goat IgG Aff - Purified Hu E, P, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

TSPO / BZRP antibody

Western Blot: TSPO Antibody [NBP1-45769] - analysis of PBR expression using:_x000d_
Lane 1: Jurkat cell lysate_x000d_
Lane 2: Recombinant PBR _x000d_
Lane 3: Rat kidney tissue lysate_x000d_ Rabbit IgG Aff - Purified Hu, Ms, Rt C, P, WB
0.1 mg / €470.00
  Novus Biologicals Inc.

TSPO / BZRP antibody

Immunohistochemistry-Paraffin: TSPO Antibody (EPR5384) [NBP1-95674] - Analysis of paraffin-embedded human colon tissue using anti-TSPO. Rabbit EPR5384 Purified Hu, Ms F, ICC/IF, IP, P, WB
0.1 ml / €480.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

TSPO / BZRP (transcript variant PBR)

TSPO / BZRP Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

TSPO / BZRP

TSPO / BZRP Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

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