Tuberin / TSC2 antibody

Principal name

Tuberin / TSC2 antibody

Alternative names for Tuberin / TSC2 antibody

Tuberous sclerosis 2 protein, TSC4

SwissProt ID

P49815 (Human), P49816 (Rat), Q61037 (Mouse)

Gene ID

7249 (TSC2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Mky (Monkey)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Paraffin Sections (P), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Dot blot (Dot)

Background of Tuberin / TSC2 antibody

Tuberous sclerosis complex (TSC) is an autosomal dominant tumor syndrome caused by mutations in either of the TSC1 or TSC2 tumor suppressor genes. The products of these genes form a protein complex that indirectly decreases the signaling of the mammalian Target of Rapamycin (TOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors (reviewed in 1,2). TOR activity is stimulated by Rheb, a member of the Ras superfamily of G-proteins, when the GTP/GDP ratio bound to Rheb is high (3). Immunoprecipitated TSC1/TSC2 has been shown to stimulate Rheb GTPase activity in vitro (4), suggesting that the TSC1/TSC2 complex decreases the ability of Rheb to stimulate TOR activity. This is supported by experiments showing that overexpression of TSC1 and TSC2 results in a significant decrease in the GTP/GDP ratio bound to Rheb and the inhibition of cell growth (4,5). At least three isoforms of TSC2 exist.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Tuberin / TSC2 pSer664 antibody

  Rabbit Polyclonal anti-TSC2 Phospho (Ser664) Antibody  
Formalin-fixed paraffin-embedded human epidermis tissue was stained with Poly6359 and developed with an alkaline phosphatase chromogen substate (red color). Tissue was counterstained with H&E (blue/pink). Magnification, 40X. Rabbit IgG Aff - Purified Hu ICC/IF, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Tuberin / TSC2 antibody

Immunohistochemistry (IHC) analyzes of Tsc2 antibody (Cat.-No AP21007PU-N) in paraffin-embedded human lung carcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt P
0.1 mg / €350.00
  Acris Antibodies GmbH

Tuberin / TSC2 (C-term) antibody

  Rabbit Polyclonal TSC2 Antibody  
Western blot analysis of TSC2 in L1210 cell lysate with TSC2 antibody at 1 µg/ml in the (A) absence and (B) presence of blocking peptide. Rabbit IgG Aff - Purified Hu, Ms E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Tuberin / TSC2 (N-term) antibody

  Rabbit Polyclonal TSC2 Antibody  
Western blot analysis of TSC2 in L1210 cell lysate with TSC2 antibody at (A) 2 and (B) 4 ug/mL. Rabbit IgG Aff - Purified Hu, Ms E, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Tuberin / TSC2 antibody

  Rabbit polyclonal Tuberin (Ab-981) antibody  
Western blot analysis of extracts from 3T3 cells, using Tuberin (Ab-981) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Tuberin / TSC2 antibody

  Rabbit polyclonal TSC2 (Tyr1571) antibody(Phospho-specific)  
Immunohistochemistry analysis of paraffin-embedded human brain tissue using TSC2 (Phospho-Tyr1571) antibody.The picture on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Tuberin / TSC2 antibody

  Mouse monoclonal TSC2 Antibody  
TSC2 Antibody (Cat. #TA324345) western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).This demonstrates the TSC2 antibody detected the TSC2 protein (arrow). Mouse IgG1 249CT19.1.3 Purified Ms ICC/IF, WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

Tuberin / TSC2 antibody

  Rabbit polyclonal TSC2 Antibody (Center S1418/S1420)  
TSC2 Antibody (Center S1418/S1420) (Cat. #TA324688) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the TSC2 antibody detected the TSC2 protein (arrow). Rabbit IgG Purified Hu WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

Tuberin / TSC2 antibody

  Rabbit polyclonal Tuberin (TSC2) Antibody (S1798)  
Western blot analysis of TSC2-pS1798 (Cat. #TA324836) in Ramos cell line lysates (35ug/lane). TSC2 (arrow) was detected using the purified Pab. Rabbit Ig Aff - Purified Hu P
0.4 ml / €325.00
  OriGene Technologies, Inc.

Tuberin / TSC2 antibody

  Rabbit Polyclonal Tuberin/TSC2 Antibody  
Western blot analysis of Tuberin/TSC2 expression in 293 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Tuberin / TSC2 antibody

  Rabbit Polyclonal Phospho-Tuberin/TSC2 (Thr1462) Antibody (Phospho-specific)  
Tuberin / TSC2 Rabbit IgG Purified Hu, Ms, Rt P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Tuberin / TSC2 antibody

  Rabbit Polyclonal Anti-TSC2 Antibody  
Tuberin / TSC2 Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Tuberin / TSC2 antibody

  Rabbit Polyclonal Anti-TSC2 Antibody  
Gel: 6%SDS-PAGE,Lysate: 40 ug,,Primary antibody: (TSC2 Antibody) at dilution 1/200 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 5 minutes Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Tuberin / TSC2 antibody

Immunohistochemistry (IHC) analyzes of Tuberin/TSC2 antibody (Cat.-No.: AP06590PU-N) in paraffin-embedded humanlung carcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Tuberin / TSC2 antibody

Immunohistochemistry (IHC) analyzes of Tuberin/TSC2 antibody (Cat.-No.: AP06591PU-N) in paraffin-embedded human breast carcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt P
0.1 mg / €350.00
  Acris Antibodies GmbH

Tuberin / TSC2 antibody

Brain, cerebellum: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit Aff - Purified Hu, Ms P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Tuberin / TSC2 antibody

Figure 1. Staining  TSC2 in Pancreas tissue by Immunohistochemistry using Formalin-Fixed Paraffin-Embedded (FFPE) tissue. Rabbit Aff - Purified Hu, Ms ICC/IF, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Tuberin / TSC2 pSer939 antibody

Dot blot analysis of anti-TSC2-pSer939 Phospho-specific Pab (Cat.AP12837PU-N) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml. Rabbit Ig Aff - Purified Hu
0.4 ml / €370.00
  Acris Antibodies GmbH

Tuberin / TSC2 pSer664 antibody

Dot blot analysis of anti-TSC2 pSer664 Phospho-specific antibody (Cat.#AP12853PU-N) on Nitrocellulose membrane. 50 ng of Phospho-peptide or Non Phospho-peptide per Dot were adsorbed. Antibody working concentrations are 0.5 µg/ml. Rabbit Ig Aff - Purified Hu Dot
0.4 ml / €370.00
  Acris Antibodies GmbH

Tuberin / TSC2 pSer1798 antibody

Dot blot analysis of anti-TSC2-pSer1798 Phospho-specific Pab (Cat#AP12894PU-N) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml. Rabbit Ig Aff - Purified Hu Dot
0.4 ml / €370.00
  Acris Antibodies GmbH

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