Tuberin / TSC2 antibody

Principal name

Tuberin / TSC2 antibody

Alternative names for Tuberin / TSC2 antibody

Tuberous sclerosis 2 protein, TSC4

SwissProt ID

P49815 (Human), P49816 (Rat), Q61037 (Mouse)

Gene ID

7249 (TSC2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Mky (Monkey)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Dot blot (Dot), Frozen Sections (C)

Background of Tuberin / TSC2 antibody

Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disorder that is caused by mutation in either the TSC1 (hamartin) or TSC2 (tuberin) gene. TSC1 and TSC2 proteins form a physical and functional heterodimer in vivo that inhibits ribosomal protein S6 kinase 1 (S6K1) and activates eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) by inhibition of the mammalian target of rapamycin (mTOR). TSC2 belongs to small GTPase protein of the Ras superfamily, contain a Rap-GAP domain. Predicted molecular weight 201 kD. Ser664 TSC2 phosphorylation leads to TSC1-TSC2 dissociation and markedly impairs TSC2 ability to inhibit mTOR signaling, cell proliferation, and oncogenic transformation. Erk (extracellular signal-regulated kinase) may contribute to tumorigenesis by phosphorylating TSC2 at specific residues, particularly S664. The Poly6359 antibody recognizes human phospho-TSC2 (Ser664) and has been shown to be useful for immunoflorence staining. This antibody does not detect TSC2 phosphorylated at other sites. 14-3-3, AKT1, AKT3, ERK2, TSC1, Protein kinase B beta, Estrogen receptor alpha, SMAD3, p27Kip1, RAB5

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Tuberin / TSC2 pSer664 antibody

Formalin-fixed paraffin-embedded human epidermis tissue was stained with Poly6359 and developed with an alkaline phosphatase chromogen substate (red color). Tissue was counterstained with H&E (blue/pink). Magnification, 40X. Rabbit IgG Aff - Purified Hu ICC/IF, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Tuberin / TSC2 pSer664 antibody

Formalin-fixed paraffin-embedded human epidermis tissue was stained with Poly6359 and developed with an alkaline phosphatase chromogen substate (red color). Tissue was counterstained with H&E (blue/pink). Magnification, 40X. Rabbit IgG Aff - Purified Hu ICC/IF, P
25 µl / €230.00
  Acris Antibodies GmbH

Tuberin / TSC2 antibody

Immunohistochemistry (IHC) analyzes of Tsc2 antibody (Cat.-No AP21007PU-N) in paraffin-embedded human lung carcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt P
0.1 mg / €350.00
  Acris Antibodies GmbH

Tuberin / TSC2 (C-term) antibody

Western blot analysis of TSC2 in L1210 cell lysate with TSC2 antibody at 1 µg/ml in the (A) absence and (B) presence of blocking peptide. Rabbit IgG Aff - Purified Hu, Ms E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Tuberin / TSC2 (N-term) antibody

Western blot analysis of TSC2 in L1210 cell lysate with TSC2 antibody at (A) 2 and (B) 4 ug/mL. Rabbit IgG Aff - Purified Hu, Ms E, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Tuberin / TSC2 antibody

Western blot analysis of extracts from 3T3 cells, using Tuberin (Ab-981) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Tuberin / TSC2 antibody

Western blot analysis of extracts from HeLa cells, treated with Anisomycin (25ug/ml, 30mins), using Tuberin/TSC2 (Ab-939) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Tuberin / TSC2 antibody

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using Tuberin/TSC2 antibody.The picture on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Tuberin / TSC2 antibody

TSC2 Antibody (Cat. #TA324345) western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).This demonstrates the TSC2 antibody detected the TSC2 protein (arrow). Mouse IgG1 249CT19.1.3 Purified Ms ICC/IF, WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

Tuberin / TSC2 antibody

TSC2 Antibody (Center S1418/S1420) (Cat. #TA324688) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the TSC2 antibody detected the TSC2 protein (arrow). Rabbit IgG Purified Hu WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

Tuberin / TSC2 antibody

Western blot analysis of TSC2-pS1798 (Cat. #TA324836) in Ramos cell line lysates (35ug/lane). TSC2 (arrow) was detected using the purified Pab. Rabbit Ig Aff - Purified Hu P
0.4 ml / €325.00
  OriGene Technologies, Inc.

Tuberin / TSC2 antibody

Western blot analysis of Tuberin/TSC2 expression in 293 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Tuberin / TSC2 antibody

Immunohistochemistry (IHC) analyzes of Tuberin/TSC2 antibody (Cat.-No.: AP06590PU-N) in paraffin-embedded humanlung carcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Tuberin / TSC2 antibody

Immunohistochemistry (IHC) analyzes of Tuberin/TSC2 antibody (Cat.-No.: AP06591PU-N) in paraffin-embedded human breast carcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt P
0.1 mg / €350.00
  Acris Antibodies GmbH

Tuberin / TSC2 antibody

Brain, cerebellum: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit Aff - Purified Hu, Ms P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Tuberin / TSC2 antibody

Figure 1. Staining  TSC2 in Pancreas tissue by Immunohistochemistry using Formalin-Fixed Paraffin-Embedded (FFPE) tissue. Rabbit Aff - Purified Hu, Ms ICC/IF, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Tuberin / TSC2 pSer939 antibody

Dot blot analysis of anti-TSC2-pSer939 Phospho-specific Pab (Cat.AP12837PU-N) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml. Rabbit Ig Aff - Purified Hu
0.4 ml / €370.00
  Acris Antibodies GmbH

Tuberin / TSC2 pSer664 antibody

Dot blot analysis of anti-TSC2 pSer664 Phospho-specific antibody (Cat.#AP12853PU-N) on Nitrocellulose membrane. 50 ng of Phospho-peptide or Non Phospho-peptide per Dot were adsorbed. Antibody working concentrations are 0.5 µg/ml. Rabbit Ig Aff - Purified Hu Dot
0.4 ml / €370.00
  Acris Antibodies GmbH

Tuberin / TSC2 pSer1798 antibody

Dot blot analysis of anti-TSC2-pSer1798 Phospho-specific Pab (Cat#AP12894PU-N) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml. Rabbit Ig Aff - Purified Hu Dot
0.4 ml / €370.00
  Acris Antibodies GmbH

Tuberin / TSC2 pSer1420 antibody

Dot blot analysis of anti-TSC2-pSer1420 Phospho-specific Pab (Cat#AP12895PU-N) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml. Rabbit Ig Aff - Purified Hu
0.4 ml / €370.00
  Acris Antibodies GmbH

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