Tumor necrosis factor (TNF-alpha) antibody

Principal name

Tumor necrosis factor (TNF-alpha) antibody

Alternative names for Tumor necrosis factor (TNF-alpha) antibody

TNF, TNF-a, TNFA, TNFSF2, Cachectin, Tumor necrosis factor ligand superfamily member 2

SwissProt ID

P01375 (Human), P04924 (Rabit), P06804 (Mouse), P16599 (Rat), P19101 (Felca), P23383 (Sheep), P23563 (Pig), P29553 (Horse), P48094 (Macmu), P51435 (Cavpo), P51742 (Canfa), Q06599 (Bovin)

Gene ID

7124 (TNF), 103694380 (LOC103694380), 280943, 403922, 100033834, 397086, 21926 (Tnf), 24835

Available reactivities

Hu (Human), Rt (Rat), Ms (Mouse), Por (Porcine), Bov (Bovine), Eq (Equine), Mky (Monkey), GP (Guinea Pig), Can (Canine), Rhesus Mky (Rhesus Monkey), Hst (Hamster), Prim (Primate), Fe (Feline), Rb (Rabbit), Ze (Zebrafish), Bab (Baboon)

Available hosts

Mouse, Goat, Rabbit, Rat, Chicken, Sheep

Available applications

Frozen Sections (C), Enzyme Immunoassay (E), Functional assay (FN), ELISA (capture) (E(capture)), ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Immunoprecipitation (IP), Radioimmunoassay (R), Flow Cytometry (F), Neutralisation (NEUT), Luminex (LMNX)

Background of Tumor necrosis factor (TNF-alpha) antibody

The prototype ligand of the TNF superfamily, TNF-./TNFSF1A, is a pleiotropic cytokine that plays a central role in inflammation and apoptosis . Human cells known to express TNF-. include B cells, colonic columnar epithelial cells, NK and CD3+CD56+ hepatic natural T cells, macrophages, monocytes and monocyte-derived dendritic cells, CD4+ and CD8+ T cells, mast cells, neutrophils, keratinocytes, plasma cells, and adipocytes.

It is synthesized as a 26 kDa, type II transmembrane protein that is 233 amino acids (aa) in length . It contains a 30 aa cytoplasmic domain, a 26 aa transmembrane segment, and a 177 aa extracellular region . TNF-. is assembled intracellularly to form a transmembrane, non-covalently-linked homotrimeric protein. The 157 aa residue soluble form of TNF-. (sTNF-. is released from the C-terminus of the transmembrane protein through the activity of TNF-.-converting enzyme (TACE), a membrane-bound disintegrin metalloproteinase .

TNF-. is reported to promote inflammatory cell infiltration by upregulating leukocyte adhesion molecules on endothelial cells, serve as a chemotactic agent for monocytes, and activate phagocyte killing mechanisms . Deficiencies in either TNF-. or its receptors can increase susceptibility to infection by intracellular pathogens . TNF- may also play a role in lymphoid tissue development. Knockout mice lack splenic B cell follicles and the ability to form germinal centers . Other potential physiological roles for TNF-. and its receptors include regulating the differentiation of hematopoietic stem and progenitor cells .

TNF-. has been implicated in a number of pathophysiological processes. It is associated with unregulated pro-inflammatory activity and is thought to be a critical mediator of endotoxin-induced septic shock . Cachexia (or whole body wasting) has also been associated with long-term circulating TNF-.. Other disorders with potential TNF-. involvement include asthma), type 2 diabetes, CrohnÂ?s disease, and rheumatoid arthritis.

General readings

Kwon, B. et al. (1999) Curr. Opin. Immunol. 11:340.

Idriss, H.T. and J.H. Naismith (2000) Microsc. Res. Tech. 50:184.

Sedgwick, J.D. et al. (2000) Immunol. Today 21:110.

MacEwan, D.J. (2002) Brit. J. Pharmacol. 135:855.

Pennica, D. et al. (1984) Nature 312:724.

Wang, A.M. et al. (1985) Science 228:149.

Ishisaka, R. et al. (1999) J. Biochem. 126:413.

Kriegler, M. et al. (1988) Cell 53:45.

Moss, M.L. et al. (1997) Nature 385:733.

Wang, C.Y. et al. (1998) Science 281:1680.

Peschon, J.J. et al. (1998) J. Immunol. 160:943.

Wellmer, A. et al. (2001) Infect. Immun. 69:6881.

Trevejo, J.M. et al. (2001) Proc. Natl. Acad. Sci. USA 98:12162.

Kasahara, S. et al. (2003) J. Virol. 77:2469.

Pasparakis, M. et al. (1996) J. Exp. Med. 184:1397.

Taniguchi, T. et al. (1997) Lab. Invest. 77:647.

Jacobsen, F.W. et al. (1994) Proc. Natl. Acad. Sci. USA 91:10695.

Zhang, Y. et al. (1995) Blood 86:2930.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Tumor necrosis factor (TNF-alpha) antibody

Immunohistochemistry analysis of TNF-alpha Antibody (Cat.-No AP20373PU-N) in paraffin-embedded human colon carcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Tumor necrosis factor (TNF-alpha) (1-234) antibody

Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG1 M1-C4 Purified Hu, Rt E, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

Tumor necrosis factor (TNF-alpha) antibody

Tumor necrosis factor (TNF-alpha) Mouse IgG1 4C6-H8 Purified Can, Fe, Hu, Ms, Rb, Rt, Ze C, F, ICC/IF, P
0.2 mg / €410.00
  Acris Antibodies GmbH

Tumor necrosis factor (TNF-alpha) antibody

Tumor necrosis factor (TNF-alpha) Mouse IgG1 4C6-H8 Purified Can, Fe, Hu, Ms, Rb, Rt, Ze C, F, ICC/IF, IP, P
0.1 mg / €320.00
  Acris Antibodies GmbH

Tumor necrosis factor (TNF-alpha) antibody

Tumor necrosis factor (TNF-alpha) Mouse IgG1 4C6-H8 Purified Can, Fe, Hu, Ms, Rb, Rt, Ze C, F, ICC/IF, IP, P
20 µg / €180.00
  Acris Antibodies GmbH

Tumor necrosis factor (TNF-alpha) antibody

Tumor necrosis factor (TNF-alpha) Mouse IgG1 SPM543 Purified Can, Fe, Hu, Ms, Rb, Rt, Ze C, F, ICC/IF, IP, P
0.2 mg / €410.00
  Acris Antibodies GmbH

Tumor necrosis factor (TNF-alpha) antibody

Tumor necrosis factor (TNF-alpha) Mouse IgG1 SPM543 Purified Can, Fe, Hu, Ms, Rb, Rt, Ze C, F, ICC/IF, IP, P
0.1 mg / €320.00
  Acris Antibodies GmbH

Tumor necrosis factor (TNF-alpha) antibody

Tumor necrosis factor (TNF-alpha) Mouse IgG1 SPM543 Purified Can, Fe, Hu, Ms, Rb, Rt, Ze C, F, ICC/IF, IP, P
20 µg / €180.00
  Acris Antibodies GmbH

Tumor necrosis factor (TNF-alpha) antibody

Tumor necrosis factor (TNF-alpha) Mouse IgG1 P/T2 Purified Can, Fe, Hu, Ms, Rb, Rt, Ze C, F, ICC/IF, IP, P, WB
0.2 mg / €410.00
  Acris Antibodies GmbH

Tumor necrosis factor (TNF-alpha) antibody

Tumor necrosis factor (TNF-alpha) Mouse IgG1 P/T2 Purified Can, Fe, Hu, Ms, Rb, Rt, Ze C, F, ICC/IF, IP, P, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

Tumor necrosis factor (TNF-alpha) antibody

Tumor necrosis factor (TNF-alpha) Mouse IgG1 P/T2 Purified Can, Fe, Hu, Ms, Rb, Rt, Ze C, F, ICC/IF, IP, P, WB
20 µg / €180.00
  Acris Antibodies GmbH

Tumor necrosis factor (TNF-alpha) antibody

Formalin-fixed, paraffin-embedded Rat pancreas stained with TNF alpha Monoclonal Antibody (TNF706). Mouse IgM TNF706 Purified Can, Fe, Hu, Ms, Rb, Rt, Ze F, ICC/IF, P
0.2 mg / €410.00
  Acris Antibodies GmbH

Tumor necrosis factor (TNF-alpha) antibody

Formalin-fixed, paraffin-embedded Rat pancreas stained with TNF alpha Monoclonal Antibody (TNF706). Mouse IgM TNF706 Purified Can, Fe, Hu, Ms, Rb, Rt, Ze F, ICC/IF, P
0.1 mg / €320.00
  Acris Antibodies GmbH

Tumor necrosis factor (TNF-alpha) antibody

Formalin-fixed, paraffin-embedded Rat pancreas stained with TNF alpha Monoclonal Antibody (TNF706). Mouse IgM TNF706 Purified Can, Fe, Hu, Ms, Rb, Rt, Ze F, ICC/IF, P
20 µg / €180.00
  Acris Antibodies GmbH

Tumor necrosis factor (TNF-alpha) antibody

Tumor necrosis factor (TNF-alpha) Mouse IgG1 TNF706 + P/T2 Purified Can, Fe, Hu, Ms, Rb, Rt, Ze C, F, ICC/IF, IP, P, WB
0.2 mg / €410.00
  Acris Antibodies GmbH

Tumor necrosis factor (TNF-alpha) antibody

Tumor necrosis factor (TNF-alpha) Mouse IgG1 TNF706 + P/T2 Purified Can, Fe, Hu, Ms, Rb, Rt, Ze C, F, ICC/IF, IP, P, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

Tumor necrosis factor (TNF-alpha) antibody

Tumor necrosis factor (TNF-alpha) Mouse IgG1 TNF706 + P/T2 Purified Can, Fe, Hu, Ms, Rb, Rt, Ze C, F, ICC/IF, IP, P, WB
20 µg / €180.00
  Acris Antibodies GmbH

Tumor necrosis factor (TNF-alpha) antibody

  Rabbit polyclonal anti-TNFA antibody  
Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using TNFA antibody.The picture on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, ICC/IF, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Tumor necrosis factor (TNF-alpha) antibody

  Rabbit polyclonal TNF Alpha antibody  
Western blot using Anti-Human TNF-a (RABBIT) Antibody. Membrane blocked in 1% BSA-TBS-T 30 min RT, Rb-a-TNF alpha added at 1:1000 in 1% BSA-TBS-T o/n 4°C, DyLight 649 Gt-a-Rb 611-143-122 added at 1:20,000 in MB-070 30 min RT. Rabbit Serum Hu C, E, FN, P, WB
1 ml / €1,070.00
  OriGene Technologies, Inc.

Tumor necrosis factor (TNF-alpha) antibody

  Rabbit polyclonal TNF alpha antibody  
Western blot using Anti-Human TNF-a (RABBIT) Antibody. Membrane blocked in 1% BSA-TBS-T 30 min RT, Rb-a-TNF alpha added at 1:1000 in 1% BSA-TBS-T o/n 4°C, DyLight 649 Gt-a-Rb 611-143-122 added at 1:20,000 in MB-070 30 min RT. Rabbit Purified Hu C, E, FN, P, WB
1 mg / €1,070.00
  OriGene Technologies, Inc.

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