Tumor protein p73 (TP73) antibody

Principal name

Tumor protein p73 (TP73) antibody

Alternative names for Tumor protein p73 (TP73) antibody

p53-like transcription factor, p53-related protein

SwissProt ID

O15350 (Human), Q9JJP2 (Mouse)

Gene ID

7161 (TP73), 22062 (Trp73)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Mky (Monkey), Ze (Zebrafish)

Available hosts

Mouse, Rabbit

Available applications

Frozen Sections (C), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunoprecipitation (IP), PLA/Proximity ligation assay (PLA), Immunocytochemistry/Immunofluorescence (ICC/IF), ChIP assay (ChIP), Electrophoretic Mobility Shift Assay (EMSA), Enzyme Immunoassay (E)

Background of Tumor protein p73 (TP73) antibody

p73 protein is a member of the p53 family of proteins. The tumor-suppressor protein p53 exhibits sequence specific DNA binding, directly interacts with various cellular and viral proteins, and induces cell cycle arrest in response to DNA damage. In response to signals generated by a variety of genotoxic stresses, e.g, UV irradiation or DNA damage, p53 is expressed and undergoes post translational modification that results in its accumulation in the nucleus. Activation of p53 leads to cell cycle arrest and in some cases to apoptosis, resulting in the inability of genetically damaged cells to proliferate. Thus, the p53 dependent pathways help to maintain genomic stability by eliminating damaged cells. The accumulation of high levels of p53 is a potential marker for malignancy. p73 protein is expressed in either full length form (p73 alpha 80 kDa) or a shorter (p73 beta 70 kDa) mRNA variant. p73 gene was predicted to encode a protein with significant amino acid sequence similarity to p53. Each of the p53 amino acid residues implicated in direct sequence specific DNA binding is conserved in p73.
p73 can activate the transcription of p53 responsive genes and inhibit cell growth in a p53 like manner by inducing apoptosis and cell cycle arrest. p73 has been mapped at chromosome 1p36.3, which is a locus of multiple suppressor genes for tumors including neuroblastoma and other cancers. c-Abl stimulates p73 mediated transactivation and apoptosis. This regulation of p73 by c-Abl in response to DNA damage was also demonstrated by a failure of ionizing radiation induced apoptosis after disruption of c-Abl-p73 interaction. The p73 protein can activate p53 responsive promoters and induce apoptosis in cells deficient in p53, which proves that inactivation of p53 family members may contribute to the biological properties of a subset of p53 mutants. The transcriptional activities of p53, p73 alpha, and p73 beta to induce their common cellular target genes differ among one another. Despite the high degree of similarity between p53 and p73, adenovirus E1B 55K, simian virus 40 T, and human papilloma virus E6 do not physically interact with p73, indicating that the functions of these two proteins may differ.

General readings

This product has been used in:Marin MC et al. Viral oncoproteins discriminate between p53 and the p53 homolog p73. Mol Cell Biol 18:6316-24 (1998). PubMed PMID: 9774648

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Tumor protein p73 (TP73) antibody

Western Blot: Delta Np73 Antibody (38C674.2) [TA337074] - Delta Np73 Antibody (38C674.2) analysis for Np73 using TA337074 at 1 ug/ml in A) a cell line transfected with Np73 cDNA, B) HeLa, and C) NIH 3T3 cell lysate. Mouse IgG1 38C674.2 Purified Hu, Ms, Rt C, ChIP, ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Tumor protein p73 (TP73) antibody

Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-TP73 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA506452) Mouse IgG1 OTI2H2 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Tumor protein p73 (TP73) antibody

Immunohistochemical staining of paraffin-embedded Human lymph node tissue within the normal limits using anti-TP73 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA506453) Mouse IgG1 OTI1B5 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Tumor protein p73 (TP73) antibody

Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-TP73 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA506470) Mouse IgG1 OTI2H5 Purified Hu ICC/IF, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

Tumor protein p73 (TP73) antibody

Western blot analysis of extracts from K562 cells, using p73 (Ab-99) Antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Tumor protein p73 (TP73) antibody

Western blot analysis of extracts from Jurkat cells, using p73 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Tumor protein p73 (TP73) antibody

Predicted band size: 70 kDa . Positive control: Human brain malignant glioma tissue lysate. Recommended dilution: 1/200-1000. (Gel: 10%SDS-PAGE Lysate: 60 ug per lane Primary antibody: 1/300 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 2 minutes) Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Tumor protein p73 (TP73) antibody

Predicted band size: 70 kDa . Positive control: Human fetal muscle tissue and 231 cell lysate. Recommended dilution: 1/200-1000. (Gel: 10%SDS-PAGE Lane1: Human fetal muscle tissue lysate Lane2: 231 cell lysate Lysates: 60 ug per lane Primary antibody: 1/300 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 10 minutes) Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Tumor protein p73 (TP73) antibody

TP73 Antibody (Center) (Cat. #TA325079) western blot analysis in K562 cell line and mouse brain tissue lysates (35ug/lane).This demonstrates the TP73 antibody detected the TP73 protein (arrow). Rabbit IgG Purified Hu, Ms F, ICC/IF, P, WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

Tumor protein p73 (TP73) antibody

Western blot analysis of p73 expression in K562 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Tumor protein p73 (TP73) antibody

Western Blot: p73 [p Tyr99] Antibody [TA336320] - analysis of phosphorylated p73 in (A) recombinant fusion protein containing phosphorylated tyrosine at position 99 and (B) fusion partner without this amino acid, using this antibody. 25 ug/ml. Rabbit Purified Hu WB
20 µg / €325.00
  OriGene Technologies, Inc.

Tumor protein p73 (TP73) antibody

Western Blot: p73 Antibody (5B1288) [TA336443] - Analysis of p73 in HeLa cell lysate (Cat no. NBP2-25045) using this antibody at 1 ug/ml. Mouse IgG1 5B1288 Purified Hu, Ms ChIP, ICC/IF, IP, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Tumor protein p73 (TP73) antibody

Western Blot: p73 Antibody (5B789) [TA336444] - Analysis of p73 in Rh30 cell lysate using this antibody at 2 ug/ml. Mouse IgG1 5B789 Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Tumor protein p73 (TP73) antibody

Western Blot: p73 Antibody (5B429) [TA337049] - analysis of p73 in A) transfected cell lysate and B) HeLa cell lysate at 2 ug/ml. Mouse IgG1 5B429 Purified Hu, Ms C, ChIP, ICC/IF, IP, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Tumor protein p73 (TP73) antibody

Western blot analysis on Jurkat cell lysate using p73 Antibody Rabbit IgG Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Tumor protein p73 (TP73) antibody

Immunohistochemical staining of paraffin-embedded Human endometrium tissue within the normal limits using anti-TP73 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA506455) Mouse IgG1 OTI2D2 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Tumor protein p73 (TP73) antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human kidney tissue using anti-TP73 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA506474) Mouse IgG2b OTI3C5 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Tumor protein p73 (TP73) antibody

ELISA: p73 Antibody Rabbit IgG Purified Hu E
0.1 mg / €325.00
  OriGene Technologies, Inc.

Tumor protein p73 (TP73) (alpha + beta) antibody

Tumor protein p73 (TP73) Mouse IgG1 ER-15 Purified Hu, Mky EMSA, ICC/IF, IP, WB
0.1 mg / €570.00
  Acris Antibodies GmbH

Tumor protein p73 (TP73) (2-13) antibody

AM08372PU-N TP73 antibody staining of Formalin-Fixed Paraffin-Embedded Human Placenta at 5 µg/ml followed by biotinylated anti-Mouse IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Mouse IgG1 38C674.2 Purified Hu, Mky, Ms, Prim ChIP, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

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