TWEAK / TNFSF12 antibody

Principal name

TWEAK / TNFSF12 antibody

Alternative names for TWEAK / TNFSF12 antibody

APO3 ligand, APO3L, DR3LG, Tumor necrosis factor ligand superfamily member 12, TNF-related weak inducer of apoptosis

SwissProt ID

O43508 (Human), O54907 (Mouse)

Gene ID

407977 (TNFSF12-TNFSF13), 21944 (Tnfsf12), 8742 (TNFSF12)

Available reactivities

Hu (Human), Ms (Mouse), Can (Canine), Rt (Rat), Eq (Equine), Rb (Rabbit), Ze (Zebrafish)

Available hosts

Rabbit, Mouse, Goat

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), Functional assay (FN), Flow Cytometry (F), Immunoprecipitation (IP)

Background of TWEAK / TNFSF12 antibody

TNFSF12 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

General readings

Jin,L., et al., (2004) J. Invest. Dermatol. 122 (5), 1175-1179

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Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

TWEAK / TNFSF12

  Purified recombinant protein of Human TNFSF12-TNFSF13 readthrough (TNFSF12-TNFSF13).  
TWEAK / TNFSF12 Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
E. coli
25 µg / €230.00
  OriGene Technologies, Inc.

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