TWSG1 / Tsg antibody

Principal name

TWSG1 / Tsg antibody

Alternative names for TWSG1 / Tsg antibody

Twisted gastrulation protein homolog 1

SwissProt ID

Q98T89 (Chick), Q9EP52 (Mouse), Q9GZX9 (Human)

Gene ID

57045 (TWSG1), 65960 (Twsg1)

Available reactivities

Hu (Human), Ms (Mouse)

Available hosts

Mouse, Rat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Frozen Sections (C)

Background of TWSG1 / Tsg antibody

Twisted gastrulation (TSG) is a secreted, cysteine-rich protein that plays a role in dorsal/ventral patterning in Drosophila and Xenopus by regulating BMP signaling. TSG was originally identified in Drosophila melanogaster and shown to be required for the differentiation of the dorsal amnioserosa cells. Studies of expression and function of Twisted Gastrulation have been performed in Drosophila and Xenopus. Xenopus TSG is expressed in the ventral regions of the embryo during gastrulation, mimicking the BMP-4 expression pattern. TSG is expressed in dorsal cells of the blastoderm embryo, where there are also high levels of activity of Dpp and Screw. Vertebrate TSGs were subsequently cloned in mouse, human, zebrafish and frog. TSG acts as an agonist for BMP signaling by modulating the inhibitory actions of the BMP antagonist, Chordin/Sog, and the cleavage properties of the metalloprotease, xolloid/tolloid. The N-terminal domain of TSG can bind BMP protein directly in vitro and shows BMP antagonist activity.

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Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

TWSG1 / Tsg

  Purified recombinant protein of Human twisted gastrulation homolog 1 (Drosophila) (TWSG1).  
TWSG1 / Tsg Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
E. coli
50 µg / €230.00
  OriGene Technologies, Inc.

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