TYK2 antibody

Principal name

TYK2 antibody

Alternative names for TYK2 antibody

JTK1, Non-receptor tyrosine-protein kinase TYK2

SwissProt ID

P29597 (Human), Q9R117 (Mouse)

Gene ID

7297 (TYK2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Por (Porcine)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection))

Background of TYK2 antibody

Tyk 2 belongs to the family of non-receptor janus tyrosine kinases, which regulate a spectrum of cellular functions occurring downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, recruit STAT transcription factors to the cytokine receptor where Tyk 2 is associated. Tyk 2 then phosphorylates proximal STAT factors, which subsequently dimerize, translocate to the nucleus, and bind to cis elements upstream of target gene promoters to regulating transcription. The canonical JAK-STAT pathway is integral to maintaining a normal immune system by stimulating proliferation, differentiation, survival, and host resistance to pathogens. Cytokine induced pro-inflammatory responses are attractive targets for anti-inflammatory therapies, specifically at the level of Jak-STAT signaling.

General readings

1. Michael H. Shaw, Gordon J. Freeman, Mark F. Scott
J. Immunol., Jun 2006; 176: 7263-7271
2. Yohei Seto, Hiroshi Nakajima, Akira Suto
J. Immunol., Jan 2003; 170: 1077
3. Dagmar Stoiber, Boris Kovacic, Christian Schuster
J. Clin. Invest., Dec 2004; 114: 1650-1658

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TYK2 antibody

Immunoperoxidase of monoclonal antibody to TYK2 on formalin-fixed paraffin-embedded human colon. [antibody concentration 3 ug/ml] Mouse IgG2a 6G12 Purified Hu E, ICC/IF, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

TYK2 antibody

Immunoperoxidase of monoclonal antibody to TYK2 on formalin-fixed paraffin-embedded human small Intestine. [antibody concentration 3 ug/ml] Mouse IgG2a 6H1 Purified Hu E, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

TYK2 antibody

Sample(30 ug whole cell lysate). A:H1299. B:HeLa S3. 5% SDS PAGE. TA308735 diluted at 1:1000 Rabbit IgG Aff - Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TYK2 antibody

Western blot analysis of TYK2 in human small intestine tissue lysate with TYK2 antibody at (A) 1 and (B) 2 ug/mL Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TYK2 antibody

Predicted band size: 134 kDa . Positive control: Raji cell lysate. Recommended dilution: 1/500-2000. (Gel: 8%SDS-PAGE Lysate: 40 ug Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TYK2 antibody

Western blot analysis of TYK2 expression in 293 cel Rabbit IgG Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TYK2 antibody

Western blot analysis using TYK2 antibody Cat.-No AM06139SU-N against truncated TYK2 recombinant protein (Lane 1) and Jurkat cell lysate (Lane 2). Mouse IgG1 8G8E9 Ascites Hu E, WB
0.1 ml / €440.00
  Acris Antibodies GmbH

TYK2 antibody

Figure 1. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using TYK2 antibody AP02648PU. Rabbit Aff - Purified P
0.1 ml / €270.00
  Acris Antibodies GmbH

TYK2 antibody

Figure 1. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using TYK2 antibody AP02648PU. Rabbit Aff - Purified P
50 µl / €230.00
  Acris Antibodies GmbH

TYK2 antibody

Kidney: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hu, Ms, Rt P
50 µg / €470.00
  Acris Antibodies GmbH

TYK2 pTyr1054 antibody

Figure 1. Western blot analysis of extracts from HT-29 cells untreated or treated with Anisomycin (20min), using TYK2 (pTyr1054) antibody AP08010PU (Lane 1 and 2). Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 ml / €320.00
  Acris Antibodies GmbH

TYK2 pTyr1054 antibody

Figure 1. Western blot analysis of extracts from HT-29 cells untreated or treated with Anisomycin (20min), using TYK2 (pTyr1054) antibody AP08010PU (Lane 1 and 2). Rabbit Aff - Purified Hu, Ms, Rt WB
50 µl / €240.00
  Acris Antibodies GmbH

TYK2 antibody

Immunohistochemistry (IHC) analyzes of Tyk 2 antibody (Cat.-No.: AP21083PU-N) in paraffin-embedded human breast carcinoma tissue. Rabbit Aff - Purified Hu, Ms ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

TYK2 antibody

TYK2 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

TYK2 antibody

TYK2 MaxPab rabbit polyclonal antibody. Western Blot analysis of TYK2 expression in mouse spleen. Rabbit Purified Hu, Ms E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

TYK2 antibody

Immunoperoxidase of monoclonal antibody to TYK2 on formalin-fixed paraffin-embedded human leiomyosarcoma. [antibody concentration 3 ug/ml] Mouse IgG2a 5A4 Purified Hu E, ICC/IF, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

TYK2 pTyr1054 antibody

Western blot analysis of extracts from HT-29 cells treated with anisomycin ( 20 min ) , using TYK2 (phospho Y1054) polyclonal antibody ( Cat # PAB7734 ). Rabbit Hu, Ms, Rt WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

TYK2 antibody

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using TYK2 (Ab-1054) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, ICC/IF, P, WB
50 µg / €205.00
  Assay Biotech

TYK2 antibody

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using TYK2 (Ab-1054) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, ICC/IF, P, WB
0.1 mg / €310.00
  Assay Biotech

TYK2 (C-term) antibody

TYK2 Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

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