Type-1 angiotensin II receptor (AT1) antibody

Principal name

Type-1 angiotensin II receptor (AT1) antibody

Alternative names for Type-1 angiotensin II receptor (AT1) antibody

AT1AR, AT1BR, AGTR1, AGTR1A, AGTR1B, AT2R1, AT2R1B

SwissProt ID

P25104 (Bovin), P30556 (Human), P43240 (Canfa), P79785 (Chick), Q9WV26 (Cavpo)

Gene ID

185 (AGTR1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Por (Porcine), Rb (Rabbit)

Available hosts

Goat, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Flow Cytometry (F)

Background of Type-1 angiotensin II receptor (AT1) antibody

Angiotensin II receptor type 1 or AT1 receptor is one of the receptors that binds the octapeptide hormone Angiotensin II (Ang II). Ang II is the peptide hormone that generates most of the known effects of the renin-angiotensin system (RAS). Ang II is generated from the angiotensinogen protein by the actions of renin, angiotensin converting enzyme (ACE) and other peptidases. Ang II has a central role in cardiovascular homeostasis by regulating vasoconstriction, rel + and water readsorption. In addition, Ang II induces cell growth and proliferation and has pro-inflammatory effects. Most of the physiological actions of Ang II are mediated by AT1 receptor a member of the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily. The AT1 receptor is coupled to a Gq/11 protein that activates phospholipase C (PLC) and leads to production of inositol 1,4,5-trisphosphate (InsP3) and intracellular Ca2+ mobilization. In addition to the rapid actions mediated by InsP3 and Ca2+ sigling, AT1 receptor elicits other sigling responses including activation of the MAPK and Jak/STAT. Together, these sigling pathways mediate most of Ang II cellular responses that include, control of hormone secretion, regulation of cell growth and apoptosis, regulation of ion channels activation and cell migration. In accordance with the pleiotropic actions of Ang II, the AT1 receptor has a wide distribution with high levels detected in the adrel gland, kidney, brain, heart, liver, etc. As is the case with many other peptide receptors, the AT1 receptor undergoes ligand-induced endocytosis, a process that contributes to receptor desensitization and sequestration and contributes to regulate receptor sigling.

General readings

Wang M, Jiang C, Wang C, Yao Q. The Role of brain angiotensinergic AT(1) receptor in the carbachol-induced natriuresis and expression of nNOS in the Locus Coeruleus (LC) and proximal convoluted tubule (PCT). Physiol Res. 2006 Aug 22; [Epub ahead of print] PMID: 16925472

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Type-1 angiotensin II receptor (AT1) antibody

  Rabbit Polyclonal Anti-Angiotensin II Receptor Type-1 (extracellular)  
Western blot analysis of mouse kidney (lanes 1 and 3) and mouse heart (lanes 2 and 4) membranes: 1, 2. Anti-Angiotensin II Receptor Type-1 (extracellular) antibody, (1:500). 3, 4. Anti-Angiotensin II Receptor Type-1 (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

Type-1 angiotensin II receptor (AT1) antibody

  Goat Polyclonal Antibody against AGTR1  
TA303151 (0.3µg/ml) staining of Mouse Liver lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Type-1 angiotensin II receptor (AT1) (Center) antibody

  Rabbit Polyclonal AGTR1 Antibody  
Western blot analysis of AGTR1 in mouse kidney tissue lysate with AGTR1 antibody at (A) 1 and (B) 2 µg/ml. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Type-1 angiotensin II receptor (AT1) antibody

  Anti-AGTR1 Rabbit Polyclonal Antibody  
Predicted band size: 41 kDa . Positive control: 231 cell lysate. Recommended dilution: 1/200-1000. (Gel: 10%SDS-PAGE Lysate: 40 ug per lane Primary antibody: 1/200dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Type-1 angiotensin II receptor (AT1) antibody

Western blot analysis with mouse RAW246.7 whole cell lysate using Type-1 angiotensin II receptor (AT1) antibody (Cat.-No. AP01262PU-N). Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Type-1 angiotensin II receptor (AT1) antibody

Human Heart, Vessel: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Hu, Ms, Rt E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Type-1 angiotensin II receptor (AT1) antibody

Immunofluorescence analysis of MCF7 cells, using AGTR1 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
50 µg / €230.00
  Assay Biotech

Type-1 angiotensin II receptor (AT1) antibody

Immunofluorescence analysis of MCF7 cells, using AGTR1 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 mg / €330.00
  Assay Biotech

8 Item(s)

per page
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