Type-2 angiotensin II receptor (AT2) antibody

Principal name

Type-2 angiotensin II receptor (AT2) antibody

Alternative names for Type-2 angiotensin II receptor (AT2) antibody

AGTR2

SwissProt ID

P35351 (Rat), P35374 (Mouse), P50052 (Human)

Gene ID

186 (AGTR2), 24182 (Agtr2), 11609

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Eq (Equine), Hst (Hamster), Mky (Monkey), Por (Porcine), Sh (Sheep), Gorilla, Rb (Rabbit)

Available hosts

Rabbit

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P)

Background of Type-2 angiotensin II receptor (AT2) antibody

Angiotensin II receptor type 2 or AT2 is one of the receptors that bind the octapeptide hormone Angiotensin II (Ang II). Ang II is the peptide hormone that generates most of the known effects of the renin-angiotensin system (RAS). Ang II is generated from the angiotensinogen protein by the actions of renin, angiotensin converting enzyme (ACE) and other peptidases. Ang II has a central role in cardiovascular homeostasis by regulating vasoconstriction, rel + and water readsorption. In addition, Ang II induces cell growth and proliferation and has pro-inflammatory effects. Most of the physiological actions of Ang II are mediated by AT1 a member of the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily. AT2 is also a GPCR, and is largely believed to have counter-regulatory roles to the ones exerted through the AT1 receptor. Hence, binding of Ang II to the AT2 receptor will result in growth arrest and apoptosis, vasodilatation and hypotension. Although the AT2 receptor is structurally a member of the GPCR superfamily, the sigling mechanisms elicited following AT2 receptor activation are not fully clarified. Recent evidence indicates that the AT2 receptor sigls through the Gia2 and the Gia3 proteins and through the activation of phosphotyrosine phosphatases such as SHP-1. AT2 receptor distribution is more restricted than that of the AT1 receptor. The highest expression levels of AT2 have been found in the fetus, which is followed by a marked decrease shortly after birth. Nevertheless, significant AT2 receptor expression can be detected in the heart, kidney, vascular endothelial cells and brain, among others.

  1. Quick-Filters:
  2. Cited (1)
  3. Highly Validated (1)

20 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Type-2 angiotensin II receptor (AT2) antibody

  Rabbit Polyclonal Anti-Angiotensin II Receptor Type-2 (extracellular)  
Western blot analysis of mouse MS1 endothelial cells: 1. Anti-Angiotensin II Receptor Type-2 (extracellular) antibody, (1:400). 2. Anti-Angiotensin II Receptor Type-2 (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

Type-2 angiotensin II receptor (AT2) antibody

  Rabbit Polyclonal AGTR2 Antibody  
Western blot analysis of AGTR2 in mouse liver tissue lysate with AGTR2 antibody at 0.5 µg/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Type-2 angiotensin II receptor (AT2) antibody

  AGTR2 / AT2 Rabbit Polyclonal (Internal) Antibody  
Anti-AGTR2 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit IgG Purified Bov, Can, Eq, Gorilla, Hst, Hu, Mky, Ms, Por, Rt, Sh
50 µg / €400.00
  OriGene Technologies, Inc.

Type-2 angiotensin II receptor (AT2) antibody

  Anti-AGTR2 Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm. Positive control: Human colon and thyroid cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human colon cancer tissue using AGTR2 antibody at dilution 1/15, on the right is treated with the synthetic peptide. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Type-2 angiotensin II receptor (AT2) antibody

  Rabbit Polyclonal Anti-AGTR2 Antibody  
AGTR2 antibody validated by WB using Mouse brain membranes at 1:4,000. Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

CRISPR

Catalog No. Species Donor Vector  

AGTR2 - human gene knockout kit via CRISPR

AGTR2 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

AGTR2 - human gene knockout kit via CRISPR

AGTR2 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

AGTR2 - human gene knockout kit via CRISPR

AGTR2 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

AGTR2 - human gene knockout kit via CRISPR

AGTR2 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Agtr2 - mouse gene knockout kit via CRISPR

Agtr2 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Agtr2 - mouse gene knockout kit via CRISPR

Agtr2 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Agtr2 - mouse gene knockout kit via CRISPR

Agtr2 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Agtr2 - mouse gene knockout kit via CRISPR

Agtr2 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

AGTR2 overexpression lysate

AGTR2 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, AGTR2 (mGFP-tagged) - Human angiotensin II receptor, type 2 (AGTR2), 200 uL, >10^7 TU/mL

Lenti ORF particles, AGTR2 (mGFP-tagged) - Human angiotensin II receptor, type 2 (AGTR2), 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, AGTR2 (Myc-DDK tagged) - Human angiotensin II receptor, type 2 (AGTR2) , 200 uL, >10^7 TU/mL

Lenti ORF particles, AGTR2 (Myc-DDK tagged) - Human angiotensin II receptor, type 2 (AGTR2) , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Agtr2 (GFP-tagged) - Mouse angiotensin II receptor, type 2 (Agtr2), 200 uL, >10^7 TU/mL

Lenti ORF particles, Agtr2 (GFP-tagged) - Mouse angiotensin II receptor, type 2 (Agtr2), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Agtr2 (Myc-DDK-tagged) - Mouse angiotensin II receptor, type 2 (Agtr2), 200 uL, >10^7 TU/mL

Lenti ORF particles, Agtr2 (Myc-DDK-tagged) - Mouse angiotensin II receptor, type 2 (Agtr2), 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Agtr2 (GFP-tagged ORF) - Rat angiotensin II receptor, type 2 (Agtr2), 200 uL, >10^7 TU/mL

Lenti ORF particles, Agtr2 (GFP-tagged ORF) - Rat angiotensin II receptor, type 2 (Agtr2), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Agtr2 (Myc-DDK-tagged ORF) - Rat angiotensin II receptor, type 2 (Agtr2), 200 uL, >10^7 TU/mL

Lenti ORF particles, Agtr2 (Myc-DDK-tagged ORF) - Rat angiotensin II receptor, type 2 (Agtr2), 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

20 Item(s)

per page
  • LinkedIn