Type-2 angiotensin II receptor (AT2) antibody

Principal name

Type-2 angiotensin II receptor (AT2) antibody

Alternative names for Type-2 angiotensin II receptor (AT2) antibody

AGTR2

SwissProt ID

P35351 (Rat), P35374 (Mouse), P50052 (Human)

Gene ID

186 (AGTR2), 24182 (Agtr2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Eq (Equine), Hst (Hamster), Mky (Monkey), Por (Porcine), Sh (Sheep), Gorilla, Rb (Rabbit)

Available hosts

Rabbit

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Flow Cytometry (F)

Background of Type-2 angiotensin II receptor (AT2) antibody

Angiotensin II receptor type 2 or AT2 is one of the receptors that bind the octapeptide hormone Angiotensin II (Ang II). Ang II is the peptide hormone that generates most of the known effects of the renin-angiotensin system (RAS). Ang II is generated from the angiotensinogen protein by the actions of renin, angiotensin converting enzyme (ACE) and other peptidases. Ang II has a central role in cardiovascular homeostasis by regulating vasoconstriction, rel + and water readsorption. In addition, Ang II induces cell growth and proliferation and has pro-inflammatory effects. Most of the physiological actions of Ang II are mediated by AT1 a member of the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily. AT2 is also a GPCR, and is largely believed to have counter-regulatory roles to the ones exerted through the AT1 receptor. Hence, binding of Ang II to the AT2 receptor will result in growth arrest and apoptosis, vasodilatation and hypotension. Although the AT2 receptor is structurally a member of the GPCR superfamily, the sigling mechanisms elicited following AT2 receptor activation are not fully clarified. Recent evidence indicates that the AT2 receptor sigls through the Gia2 and the Gia3 proteins and through the activation of phosphotyrosine phosphatases such as SHP-1. AT2 receptor distribution is more restricted than that of the AT1 receptor. The highest expression levels of AT2 have been found in the fetus, which is followed by a marked decrease shortly after birth. Nevertheless, significant AT2 receptor expression can be detected in the heart, kidney, vascular endothelial cells and brain, among others.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Type-2 angiotensin II receptor (AT2) antibody

Western blot analysis of mouse MS1 endothelial cells: 1. Anti-Angiotensin II Receptor Type-2 (extracellular) antibody, (1:400). 2. Anti-Angiotensin II Receptor Type-2 (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

Type-2 angiotensin II receptor (AT2) antibody

Western blot analysis of AGTR2 in mouse liver tissue lysate with AGTR2 antibody at 0.5 µg/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Type-2 angiotensin II receptor (AT2) antibody

Anti-AGTR2 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit IgG Purified Bov, Can, Eq, Gorilla, Hst, Hu, Mky, Ms, Por, Rt, Sh
50 µg / €345.00
  OriGene Technologies, Inc.

Type-2 angiotensin II receptor (AT2) antibody

Predicted cell location: Cytoplasm. Positive control: Human colon and thyroid cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human colon cancer tissue using AGTR2 antibody at dilution 1/15, on the right is treated with the synthetic peptide. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Type-2 angiotensin II receptor (AT2) antibody

AGTR2 antibody validated by WB using Mouse brain membranes at 1:4,000. Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

Type-2 angiotensin II receptor (AT2) Control Peptide

Type-2 angiotensin II receptor (AT2)
50 µg / €160.00
  Acris Antibodies GmbH

Type-2 angiotensin II receptor (AT2) (N-term) antibody

Mouse brain membranes; AGTR2 antibody - N-terminal region (ARP59983_P050) validated by WB using Mouse brain membranes at 1:4,000.; AGTR2 antibody - N-terminal region (ARP59983_P050) in Mouse brain membranes cells using Western Blot Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

Type-2 angiotensin II receptor (AT2) antibody

Type-2 angiotensin II receptor (AT2) Rabbit Aff - Purified Hu P
50 µg / €440.00
  Novus Biologicals Inc.

Type-2 angiotensin II receptor (AT2) antibody

Type-2 angiotensin II receptor (AT2) Rabbit Purified Hu ICC/IF, P, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

Type-2 angiotensin II receptor (AT2) antibody

Immunohistochemistry-Paraffin: Angiotensin II Type 2 Receptor Antibody [NBP1-77368] - Rat liver tissue with AGTR2 antibody at 5 ug/mL._x000d_ Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €440.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Type-2 angiotensin II receptor (AT2)

Type-2 angiotensin II receptor (AT2) Human Purified
2 µg / €300.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

AGTR2 overexpression lysate

AGTR2 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

12 Item(s)

per page
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