TYRO3 antibody

Principal name

TYRO3 antibody

Alternative names for TYRO3 antibody

BYK, DTK, RSE, SKY, Tyrosine-protein kinase receptor TYRO3

SwissProt ID

P55144 (Mouse), P55146 (Rat), Q06418 (Human), Q8QFP9 (Xenla), Q98949 (Chick), Q9YI66 (Danre)

Gene ID

7301 (TYRO3)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Mky (Monkey), Can (Canine)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Frozen Sections (C), Flow Cytometry (F), Luminex (LMNX)

Background of TYRO3 antibody

The transmembrane signalling by receptor tyrosine kinases invloves the activation of cell surface receptors as a result of ligand binding and subsequenct actviation of cytoplasmic tyrosine kinase domain that resides in the cytoplasmic loop. The tryrosine kinase receptors are critical for cell survival, proliferation and cell differentiation. The Tyro 3 family receptor members include Tyro 3 (also known as Sky, Brt, Tif, Rse, Dtk or Etk); Axl ½ (also known as Ark, Ufo, Tyro 7) and Mer (also known as Eyk, Nyk, tyro 12) (1-2). These receptors share distinctive structural domains in the extracellular region, composed of 2 immunoglobulin-related domains linked to 2 fibronectin type III repeats. These structural motifs are characteristics of cell adhesion molecules such as neuronal cell adhesion molecule (involved in proper migration of neuronal crest cells), and protein phosphatase-kappa and m.
The growth-arrest specific gene 6 (Gas 6), initially cloned form serum starved 3T3 fibroblast, causes cell cycle re-entry of serum starved 3T3 cells and also prevent them from apoptotic cell death caused by complete serum removal. The Gas 6 has been identified as a common ligand for all Tyro3 family receptor kinases including Mertk, tyro3 and Axl1/2. Triple mutant mouse (Tyro3-/-; Axl-/- ; Mer-/-) exhibit multiple major organ defects suggesting their involvement in differentiation and growth. Tyro3 receptors are widely expressed in neuronal tissue, lymphoid, vascular, reproductive and retinal tissues (3). The role of Tyro3 receptors in spermatogenesis is just emerging (4). Tyro3 is a 880-890 aa protein with multiple functional domains characteristics of receptor tyrosine kinases.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TYRO3 antibody

Immunohistochemical staining of paraffin-embedded Human breast tissue within the normal limits using anti-TYRO3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500413) Mouse IgG2a OTI5B4 Purified Hu IP, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

TYRO3 antibody

Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-TYRO3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500414) Mouse IgG2b OTI2C4 Purified Hu ICC/IF, IP, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

TYRO3 antibody

Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-TYRO3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500416) Mouse IgG1 OTI4C8 Purified Hu IP, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

TYRO3 antibody

Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-TYRO3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500417) Mouse IgG1 OTI2D11 Purified Hu ICC/IF, IP, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

TYRO3 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-TYRO3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500420) Mouse IgG2b OTI2G2 Purified Hu IP, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

TYRO3 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human pancreas tissue using anti-TYRO3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500421) Mouse IgG1 OTI9B12 Purified Hu F, ICC/IF, IP, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

TYRO3 antibody

TYRO3 ELISA with 2G2 Capture (TA600228) and 5B4 Detection (TA700226) Antibodies. Substrate used: Recombinant Human TYRO3 (TP308260) Mouse IgG1 OTI2G2 Purified Hu E, LMNX
0.1 mg / €325.00
  OriGene Technologies, Inc.

TYRO3 antibody

TYRO3 ELISA with 9B12 Capture (TA600229) and 2D11 Detection (TA700229) Antibodies. Substrate used: Recombinant Human TYRO3 (TP308260) Mouse IgG1 OTI9B12 Purified Hu E, LMNX
0.1 mg / €325.00
  OriGene Technologies, Inc.

TYRO3 antibody

TYRO3 ELISA with 2G2 Capture (TA600228) and 9B12 Detection (TA700225) Antibodies. Substrate used: Recombinant Human TYRO3 (TP308260) Mouse IgG1 OTI9B12 Purified Hu E, LMNX
50 µg / €345.00
  OriGene Technologies, Inc.

TYRO3 antibody

TYRO3 ELISA with 9B12 Capture (TA600229) and 5B4 Detection (TA700226) Antibodies. Substrate used: Recombinant Human TYRO3 (TP308260) Mouse IgG1 OTI5B4 Purified Hu E, LMNX
50 µg / €345.00
  OriGene Technologies, Inc.

TYRO3 antibody

Immunohistochemistry-Paraffin: TYRO3 Antibody (2C4) [NBP1-48040] - Immunohistochemical staining of paraffin-embedded Ovary tissue using anti-TYRO3mouse monoclonal antibody. (Dilution 1:50) Mouse 2C4 Aff - Purified Hu ICC/IF, IP, P, WB
0.1 ml / €530.00
  Novus Biologicals Inc.

TYRO3 antibody

Western blot analysis of lysate from U-87 MG cell line, using TYRO3 Antibody(Cat. #TA302134). TA302134 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug per lane. Rabbit Ig Purified Hu P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TYRO3 antibody

Western Blot: TYRO3 Antibody [TA336749] - Lane 1: Western blot on normal human brain, Lane 2: Western blot on normal mouse brain. Rabbit Purified Hu, Ms ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TYRO3 antibody

Anti-TYRO3 mouse monoclonal antibody (TA500415) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY TYRO3(RC208260). Mouse IgG2a OTI5B7 Purified Hu F, ICC/IF, IP, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

TYRO3 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TYRO3 (RC208260, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TYRO3. Rabbit IgG Purified Can, Hu, Mky, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TYRO3 antibody

TYRO3 Luminex Elisa with 5B4 Capture (TA600225) and 9B12 Detection (TA700225) Antibodies. Substrate used: Recombinant Human TYRO3 (TP308260) Mouse IgG1 OTI5B4 Purified Hu LMNX
0.1 mg / €325.00
  OriGene Technologies, Inc.

TYRO3 antibody

TYRO3 Luminex Elisa with 4C8 Capture (TA600226) and 9B12 Detection (TA700225) Antibodies. Substrate used: Recombinant Human TYRO3 (TP308260) Mouse IgG1 OTI4C8 Purified Hu LMNX
0.1 mg / €325.00
  OriGene Technologies, Inc.

TYRO3 antibody

TYRO3 Luminex Elisa with 2D11 Capture (TA600227) and 5B4 Detection (TA700226) Antibodies. Substrate used: Recombinant Human TYRO3 (TP308260) Mouse IgG1 OTI2D11 Purified Hu LMNX
0.1 mg / €325.00
  OriGene Technologies, Inc.

TYRO3 antibody

TYRO3 Luminex Elisa with 2G2 Capture (TA600228) and 5B7 Detection (TA700227) Antibodies. Substrate used: Recombinant Human TYRO3 (TP308260) Mouse IgG1 OTI5B7 Purified Hu LMNX
50 µg / €345.00
  OriGene Technologies, Inc.

TYRO3 antibody

TYRO3 Luminex Elisa with 2G2 Capture (TA600228) and 4C8 Detection (TA700228) Antibodies. Substrate used: Recombinant Human TYRO3 (TP308260) Mouse IgG1 OTI4C8 Purified Hu LMNX
50 µg / €345.00
  OriGene Technologies, Inc.

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