Tyrosine 3-monooxygenase (TH) antibody

Principal name

Tyrosine 3-monooxygenase (TH) antibody

Alternative names for Tyrosine 3-monooxygenase (TH) antibody

Tyrosine 3-hydroxylase, TYH

SwissProt ID

P04177 (Rat), P07101 (Human), P07101-2, P17289 (Bovin), P24529 (Mouse), Q76IQ3 (Canfa)

Gene ID

7054 (TH), 25085 (Th), 21823

Available reactivities

All Species, Hu (Human), Ms (Mouse), Rt (Rat), Rb (Rabbit), Mky (Monkey), Por (Porcine), Mam (Mammalia), Prim (Primate), Can (Canine), Chk (Chicken), Bov (Bovine)

Available hosts

Mouse, Rabbit, Chicken, Sheep, Goat

Available applications

Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Immunoprecipitation (IP), Dot blot (Dot)

Background of Tyrosine 3-monooxygenase (TH) antibody

Tyrosine Hydroxylase (TH) is the rate-limiting enzyme in the synthesis of the catecholamines Dopamine and Norepinephrine. TH antibodies can therefore be used as markers for dopaminergic and noradrenergic neurons in a variety of applications including depression, schizophrenia, Parkinson’s disease and drug abuse (Kish et al., 2001; Zhu et al., 2000; Zhu et al., 1999). TH antibodies can also be used to explore basic mechanisms of dopamine and norepinephrine signaling (Witkovsky et al., 2000; Salvatore et al., 2001; Dunkley et al., 2004). The activity of TH is also regulated by phosphorylation (Haycock et al., 1982; Haycock et al., 1992; Jedynak et al., 2002). Phospho-specific antibodies for the phosphorylation sites on TH can be used to great effect in studying this regulation and in identifying the cells in which TH phosphorylation occurs.

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