Tyrosine-protein kinase JAK1 antibody

Principal name

Tyrosine-protein kinase JAK1 antibody

Alternative names for Tyrosine-protein kinase JAK1 antibody

Janus kinase 1, JAK-1, JAK1A, JAK1B

SwissProt ID

O12990 (Danre), P23458 (Human), P52332 (Mouse)

Gene ID

3716 (JAK1), 3636810 (BMH1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Chk (Chicken), Por (Porcine)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Frozen Sections (C), Immunoprecipitation (IP), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of Tyrosine-protein kinase JAK1 antibody

JAK1 (Janus kinase 1) a 130 kD non-receptor protein tyrosine kinase family and a member of the JAK subfamily is a widely expressed, membrane associated kinase involved in signal transduction pathways from interferon alpha, beta, and gamma receptors, all class II receptors, cytokine receptors that utilize the common gamma chain subunit for signaling, and cytokine receptors that utilize the gp130 subunit for signaling. JAK1 phosphorylates Stat proteins and SHP2. This kinase is constitutively expressed, but expression can be increased with interferon- alpha and interferon- gamma stimulation through transcription. JAK1 activity is increased by cytokine receptor-ligand binding and can be decreased by SOCS proteins, SHP2 protein phosphatase, and PPAR agonists. JAK1 is modified by phosphorylation and has been shown to associate with IFN- alpha receptor beta chain, IFN- gamma receptor alpha chain, IL-10 receptor alpha chain, IL-2 receptor beta chain, and IL-4 receptor alpha chain. The Poly6044 antibody recognizes the N-terminal region of human JAK1 and has been shown to be useful for Western blotting.

General readings

Huang, H.M., et al. (2005) Simultaneous activation of JAK1 and JAK2 confers IL-3 independent growth on Ba/F3 pro-B cells. J. Biol. Chem. 96(2):361-375.
Booz, G.W., et al. (2002) Cytokine G-protein signaling crosstalk in cardiomyocytes: attenuation of Jak-STAT activation by endothelin-1. Mol. Cell. Biochem. 240(1-2):39-46.
Burysek, L., et al. (2002) The serine protease plasmin triggers expression of MCP-1 and CD40 in human primary monocytes via activation of p38 MAPK and Janus kinase (JAK)/STAT signaling pathways. J. Biol. Chem. 277(36):33509-33517.
Ju, H., et al. (2000) Bradykinin activates the Janus-activated kinase/signal transducers and activators of transcription (JAK/STAT) pathway in vascular endothelial cells: localization of JAK/STAT signalling proteins in plasmalemmal caveolae. Biochem. J. 351(Pt 1):257-264.
Ihle, J.N. (1996) STATs: signal transducers and activators of transcription. Cell 84(3):331-334.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Tyrosine-protein kinase JAK1 antibody

Western blot analysis of extracts from MCF7 cells using JAK1 antibody. Rabbit IgG Purified Hu, Ms, Rt P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Tyrosine-protein kinase JAK1 antibody

Western blot analysis of extracts from A549, using JAK1 (Ab-1022) Antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Tyrosine-protein kinase JAK1 antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using JAK1 antibody.The picture on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, ICC/IF, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Tyrosine-protein kinase JAK1 antibody

Predicted band size: 133 kDa . Positive control: NIH/3T3, HepG2, HT29 and MDA cells lysate. Recommended dilution: 1/ 500-1000. (Gel: 8%SDS-PAGE Lane1,2,3,4: NIH/3T3, HepG2, HT29 and MDA cells lysate Lysates: 30 ug per lane Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Tyrosine-protein kinase JAK1 antibody

Western blot analysis of JAK1 expression in EGF treated MCF7 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Tyrosine-protein kinase JAK1 pTyr1022 antibody

Immunohistochemistry (IHC) analysis of JAK1 pTyr1022 antibody (Cat.-No.: AP01620PU-N) in paraffin-embedded human breast carcinoma tissue. Rabbit Aff - Purified Hu, Ms E, P
0.1 mg / €350.00
  Acris Antibodies GmbH

Tyrosine-protein kinase JAK1 pTyr1022 antibody

Western blot analysis of extracts from HT29 cells untreated or treated with UV using JAK1 Antibody (Phospho-Tyr1022) Cat.-No AP02433PU. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 ml / €320.00
  Acris Antibodies GmbH

Tyrosine-protein kinase JAK1 pTyr1022 antibody

Western blot analysis of extracts from HT29 cells untreated or treated with UV using JAK1 Antibody (Phospho-Tyr1022) Cat.-No AP02433PU. Rabbit Aff - Purified Hu, Ms, Rt P, WB
50 µl / €240.00
  Acris Antibodies GmbH

Tyrosine-protein kinase JAK1 antibody

Figure 1. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using JAK1 antibody AP02649PU. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 ml / €270.00
  Acris Antibodies GmbH

Tyrosine-protein kinase JAK1 antibody

Figure 1. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using JAK1 antibody AP02649PU. Rabbit Aff - Purified Hu, Ms, Rt P, WB
50 µl / €230.00
  Acris Antibodies GmbH

Tyrosine-protein kinase JAK1 pTyr1022 antibody

Tyrosine-protein kinase JAK1 Rabbit Aff - Purified Hu, Ms, Rt P
0.1 mg / €350.00
  Acris Antibodies GmbH

Tyrosine-protein kinase JAK1 antibody

Tyrosine-protein kinase JAK1 Rabbit Aff - Purified Hu, Ms, Rt P
0.1 mg / €350.00
  Acris Antibodies GmbH

Tyrosine-protein kinase JAK1 antibody

Tyrosine-protein kinase JAK1 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

Tyrosine-protein kinase JAK1 pTyr1022 antibody

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using JAK1 (Phospho-Tyr1022) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €205.00
  Assay Biotech

Tyrosine-protein kinase JAK1 pTyr1022 antibody

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using JAK1 (Phospho-Tyr1022) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €310.00
  Assay Biotech

Tyrosine-protein kinase JAK1 antibody

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using JAK1 (Ab-1022) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €205.00
  Assay Biotech

Tyrosine-protein kinase JAK1 antibody

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using JAK1 (Ab-1022) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €310.00
  Assay Biotech

Tyrosine-protein kinase JAK1 antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using JAK1 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P
50 µg / €205.00
  Assay Biotech

Tyrosine-protein kinase JAK1 antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using JAK1 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P
0.1 mg / €310.00
  Assay Biotech

Tyrosine-protein kinase JAK1 pTyr1022 antibody

Immunohistochemical analysis of JAK1 (pY1022) staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Bov, Can, Chk, Hu, Ms, Por, Rt P, WB
30 µl / €210.00
  Cohesion Biosciences Ltd.

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