Tyrosine-protein kinase JAK1 antibody

Principal name

Tyrosine-protein kinase JAK1 antibody

Alternative names for Tyrosine-protein kinase JAK1 antibody

Janus kinase 1, JAK-1, JAK1A, JAK1B

SwissProt ID

O12990 (Danre), P23458 (Human), P52332 (Mouse)

Gene ID

3716 (JAK1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Chk (Chicken), Por (Porcine)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of Tyrosine-protein kinase JAK1 antibody

JAK1 (Janus kinase 1) belongs to the family of non-receptor Janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK1. JAK1 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. Upon ligand binding, JAK1 undergoes tyrosine phosphorylation and catalytic activation in an interdependent manner. Phosphorylation of tyrosine residues at positions 1022 and 1023 is believed to function in the activation
of catalytic events. The canonical JAK/Stat pathway is integral to maintaining a normal immune system by stimulating proliferation, differentiation, survival and host resistance to pathogens. Altering JAK/Stat signaling to reduce cytokine induced pro-inflammatory responses represents an attractive target for anti-inflammatory therapies.

General readings

1. Sutherland JM  et al. Suppressor of cytokine signaling 4 (SOCS4): moderator of ovarian primordial follicle activation. J Cell Physiol 227:1188-98 (2012). IHC-P ; Mouse . PubMed: 21604262

8 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Tyrosine-protein kinase JAK1 antibody

  Rabbit anti-JAK1 polyclonal antibody  
Western blot analysis of extracts from MCF7 cells using JAK1 antibody. Rabbit IgG Purified Hu, Ms, Rt P, WB
0.1 mg / €450.00
  OriGene Technologies, Inc.

Tyrosine-protein kinase JAK1 antibody

  Rabbit polyclonal JAK1 (Ab-1022) antibody  
Western blot analysis of extracts from A549, using JAK1 (Ab-1022) Antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt P, WB
0.1 ml / €335.00
  OriGene Technologies, Inc.

Tyrosine-protein kinase JAK1 antibody

  Rabbit polyclonal JAK1 (Tyr1022) antibody(Phospho-specific)  
Western blot analysis of extracts from A549 cells, using JAK1 (Phospho-Tyr1022) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms P, WB
0.1 ml / €335.00
  OriGene Technologies, Inc.

Tyrosine-protein kinase JAK1 antibody

  Rabbit Polyclonal JAK1 Antibody  
Western blot analysis of JAK1 expression in EGF treated MCF7 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €335.00
  OriGene Technologies, Inc.

Tyrosine-protein kinase JAK1 pTyr1022 antibody

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using JAK1 Antibody (Phospho-Tyr1022) Cat.-No AP02433PU. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €300.00
  OriGene Technologies GmbH

Tyrosine-protein kinase JAK1 pTyr1022 antibody

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using JAK1 Antibody (Phospho-Tyr1022) Cat.-No AP02433PU. Rabbit Aff - Purified Hu, Ms, Rt P, WB
50 µg / €230.00
  OriGene Technologies GmbH

Tyrosine-protein kinase JAK1 antibody

Figure 1. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using JAK1 antibody AP02649PU. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €300.00
  OriGene Technologies GmbH

Tyrosine-protein kinase JAK1 antibody

Figure 1. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using JAK1 antibody AP02649PU. Rabbit Aff - Purified Hu, Ms, Rt P, WB
50 µg / €230.00
  OriGene Technologies GmbH

8 Item(s)

per page
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