Tyrosine-protein kinase JAK3 antibody

Principal name

Tyrosine-protein kinase JAK3 antibody

Alternative names for Tyrosine-protein kinase JAK3 antibody

Janus kinase 3, JAK-3, L-JAK, Leukocyte janus kinase

SwissProt ID

P52333 (Human), Q62137 (Mouse), Q63272 (Rat)

Gene ID

3718 (JAK3)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Chk (Chicken), Por (Porcine), GP (Guinea Pig), Eq (Equine)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Paraffin Sections (P), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Flow Cytometry (F)

Background of Tyrosine-protein kinase JAK3 antibody

Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A AND STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Tyrosine-protein kinase JAK3 antibody

Confocal immunofluorescence analysis of 3T3-L1 cells using JAK3 mouse mAb (green). Red: Actin filaments have been labeled with DY-554 phalloidin. Blue: DRAQ5 fluorescent DNA dye. Mouse IgG1 5H2 Ascites Hu, Ms E, ICC/IF, WB
0.1 ml / €400.00
  Acris Antibodies GmbH

Tyrosine-protein kinase JAK3 antibody

Host: Rabbit; Target Name: JAK3; Sample Tissue: Breast Tumor lysates; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Bov, Can, GP, Hu, Ms, Por, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

Tyrosine-protein kinase JAK3 antibody

WB Suggested Anti-JAK3 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 62500; Positive Control: Human Small Intestine Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Por, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

Tyrosine-protein kinase JAK3 antibody

Immunohistochemistry analyzes of JAK3 antibody (AP20252PU-N) in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Tyrosine-protein kinase JAK3 antibody

Tyrosine-protein kinase JAK3 Mouse IgG 3C2 Purified Hu WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Tyrosine-protein kinase JAK3 antibody

Tyrosine-protein kinase JAK3 Mouse IgG2a 3C2 Ascites Hu E
0.2 ml / €370.00
  Abnova Taiwan Corp.

Tyrosine-protein kinase JAK3 antibody

Tyrosine-protein kinase JAK3 Mouse IgG2a 1E10 Ascites Hu E
0.2 ml / €370.00
  Abnova Taiwan Corp.

Tyrosine-protein kinase JAK3 antibody

Tyrosine-protein kinase JAK3 Mouse IgG2a 2A5 Purified Hu E
50 µg / €370.00
  Abnova Taiwan Corp.

Tyrosine-protein kinase JAK3 antibody

Tyrosine-protein kinase JAK3 Mouse IgG2a 2A5 Ascites Hu E
0.2 ml / €370.00
  Abnova Taiwan Corp.

Tyrosine-protein kinase JAK3 antibody

JAK3 monoclonal antibody (M04), clone 2D5 Western Blot analysis of JAK3 expression in K-562 ( Cat # L009V1 ). Mouse IgG2a 2D5 Ascites Hu E, WB
0.2 ml / €370.00
  Abnova Taiwan Corp.

Tyrosine-protein kinase JAK3 antibody

Detection limit for recombinant GST tagged JAK3 is approximately 3ng/ml as a capture antibody. Mouse IgG2a 3F10 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

Tyrosine-protein kinase JAK3 pTyr785 antibody

Immunohistochemistry analysis of paraffin-embedded human brain, using JAK3 (Phospho-Tyr785) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €205.00
  Assay Biotech

Tyrosine-protein kinase JAK3 pTyr785 antibody

Immunohistochemistry analysis of paraffin-embedded human brain, using JAK3 (Phospho-Tyr785) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €310.00
  Assay Biotech

Tyrosine-protein kinase JAK3 antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using JAK3 (Ab-785) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
50 µg / €205.00
  Assay Biotech

Tyrosine-protein kinase JAK3 antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using JAK3 (Ab-785) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 mg / €310.00
  Assay Biotech

Tyrosine-protein kinase JAK3 antibody

Human Small Intestine; WB Suggested Anti-JAK3 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:62500. Positive Control: Human Small Intestine; JAK3 antibody - middle region (ARP54306_P050) in Human Small Intestine cells using Western Blot Rabbit Aff - Purified Bov, Can, Chk, Hu, Ms, Por, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

Tyrosine-protein kinase JAK3 antibody

Tyrosine-protein kinase JAK3 Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €420.00
  Novus Biologicals Inc.

Tyrosine-protein kinase JAK3 antibody

Tyrosine-protein kinase JAK3 Rabbit IgG Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 mg / €360.00
  Novus Biologicals Inc.

Tyrosine-protein kinase JAK3 antibody

Tyrosine-protein kinase JAK3 Rabbit IgG Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
50 µg / €290.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Tyrosine-protein kinase JAK3

Tyrosine-protein kinase JAK3 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

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