TYW1 / RSAFD1 antibody

Principal name

TYW1 / RSAFD1 antibody

Alternative names for TYW1 / RSAFD1 antibody

tRNA wybutosine-synthesizing protein 1 homolog, tRNA-yW-synthesizing protein, Radical S-adenosyl methionine and flavodoxin domain-containing protein 1

SwissProt ID

Q08960 (Yeast), Q08C92 (Danre), Q2KHP8 (Xenla), Q8BJM7 (Mouse), Q9NV66 (Human)

Gene ID

55253 (TYW1), 100929 (Tyw1)

Available reactivities

Hu (Human), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Enzyme Immunoassay (E)

Background of TYW1 / RSAFD1 antibody

TYW1, also known as TYW1A, RSAFD1 or YPL207W, is a 732 amino acid protein containing one flavodoxin-like domain that participates in the wybutosine-tRNA (Phe) biosynthesis pathway. Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TYW1 is involved in a multistep enzymatic reaction that stabilizes codon-anticodon base-pairing during the ribosomal decoding process, thereby ensuring correct translation. TYW1 binds to one 4Fe-4S cluster and is located on human chromosome 7. Defects in some of the genes on chromosome 7 have been linked to Osteogenesis imperfecta, Williams-Beuren syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome, suggesting that TYW1 may play a role in these conditions.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TYW1 / RSAFD1 (C-term) antibody

  Rabbit Polyclonal TYW1 Antibody  
Western blot analysis of TYW1 in human lung tissue lysate with TYW1 antibody at 1 ug/mL. Rabbit Aff - Purified Hu, Rt E, WB
0.1 mg / €415.00
  OriGene Technologies, Inc.

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