UBA3 / UBE1C antibody

Principal name

UBA3 / UBE1C antibody

Alternative names for UBA3 / UBE1C antibody

Ubiquitin-activating enzyme 3, Ubiquitin-activating enzyme E1C, NEDD8-activating enzyme E1C, NEDD8-activating enzyme E1 catalytic subunit, Ubiquitin-like modifier-activating enzyme 3

SwissProt ID

Q8C878 (Mouse), Q8TBC4 (Human), Q99MI7 (Rat)

Gene ID

9039 (UBA3)

Available reactivities

Hu (Human), Ms (Mouse), Bov (Bovine), Can (Canine), Chk (Chicken), Rt (Rat), Ze (Zebrafish), African clawed frog, Eq (Equine), Por (Porcine), Rb (Rabbit)

Available hosts

Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of UBA3 / UBE1C antibody

UBA3 is a catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. UBA3 down-regulates steroid receptor activity. UBA3 is necessary for cell cycle progression.The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

UBA3 / UBE1C antibody

  Rabbit Polyclonal Anti-UBA3 Antibody  
WB Suggested Anti-UBA3 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 1562500; Positive Control: Human Pancreas Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Por, Rb, Rt, Ze P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

UBA3 / UBE1C (C-term) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Purified Hu, Ms P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

UBA3 / UBE1C (transcript variant 1)

  Recombinant protein of human ubiquitin-like modifier activating enzyme 3 (UBA3), transcript variant 1  
UBA3 / UBE1C Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

UBA3 / UBE1C (transcript variant 2)

  Recombinant protein of human ubiquitin-like modifier activating enzyme 3 (UBA3), transcript variant 2  
UBA3 / UBE1C Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

UBA3 / UBE1C (1-463, His-tag)

UBA3 / UBE1C Human Purified > 90 % by SDS - PAGE E. coli
0.5 mg / €730.00
  Acris Antibodies GmbH

UBA3 / UBE1C (1-463, His-tag)

UBA3 / UBE1C Human Purified > 90 % by SDS - PAGE E. coli
0.1 mg / €300.00
  Acris Antibodies GmbH

Lysates

Catalog No.    

UBA3 overexpression lysate

UBA3 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, UBA3 (mGFP-tagged) - Human ubiquitin-like modifier activating enzyme 3 (UBA3), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, UBA3 (mGFP-tagged) - Human ubiquitin-like modifier activating enzyme 3 (UBA3), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, UBA3 (Myc-DDK tagged) - Human ubiquitin-like modifier activating enzyme 3 (UBA3), transcript variant 2 , 200 uL, >10^7 TU/mL

Lenti ORF particles, UBA3 (Myc-DDK tagged) - Human ubiquitin-like modifier activating enzyme 3 (UBA3), transcript variant 2 , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Lenti ORF particles, UBE1C (mGFP-tagged) - Human ubiquitin-activating enzyme E1C (UBA3 homolog, yeast) (UBE1C), transcript variant 3, 200 uL, >10^7 TU/mL

Lenti ORF particles, UBE1C (mGFP-tagged) - Human ubiquitin-activating enzyme E1C (UBA3 homolog, yeast) (UBE1C), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €1,070.00
  OriGene Technologies, Inc.

Lenti ORF particles, UBE1C (Myc-DDK tagged) - Human ubiquitin-activating enzyme E1C (UBA3 homolog, yeast) (UBE1C), transcript variant 3 , 200 uL, >10^7 TU/mL

Lenti ORF particles, UBE1C (Myc-DDK tagged) - Human ubiquitin-activating enzyme E1C (UBA3 homolog, yeast) (UBE1C), transcript variant 3 , 200 uL, >10^7 TU/mL  
200 µl / €960.00
  OriGene Technologies, Inc.

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