UBE2V1 / CROC1 antibody
Principal name
UBE2V1 / CROC1 antibody
Alternative names for UBE2V1 / CROC1 antibody
Ubiquitin-conjugating enzyme E2 variant 1, UEV-1, UEV1, UBE2V, CROC-1, P/OKcl.19, TRAF6-regulated IKK activator 1 beta Uev1A
Ncbi ID
9606, NP_001027459.1, NM_001032288, NP_001027459, NP_954673, NP_954595, NP_075719.1, NM_023230, NM_022442, NM_199144
Available reactivities
Available hosts
Available applications
Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)
Background of UBE2V1 / CROC1 antibody
The CROC1 isoforms, also known as UBE2V1, show sequence similarity to ubiquitin-conjugating enzymes (UBCs, or E2s) but lack the conserved cysteine residue critical to catalytic activity of E2s.1 Northern blot analysis detected approximately 2.1- and 2.5-kb CROC1 transcripts in all human tissues examined, with the highest levels in brain, skeletal muscle, and kidney. Partial human intestinal epithelial cell cDNAs have been isolated containing the 3-primecoding sequence and 3-prime untranslated region of UBE2V1, also called UEV1.2 UEV1 does not have ubiquitin-conjugating activity in vitro. UEV1 transcripts are downregulated upon differentiation of a colon carcinoma cell line.1 Constitutive expression of exogenous UEV1 protein in these colon carcinoma cells inhibits their capacity to differentiate upon confluence and induces changes in cell cycle behavior associated with inhibition of CDK1. A heterodimeric protein complex has been identified that links TRAF6 to IKK activation.3 Peptide mass fingerprinting analysis revealed that this complex is composed of the ubiquitin conjugating enzyme UBC13 and the UBC-like protein UBE2V1, also called UEV1A. TRAF6, a RING domain protein, functions together with UBC13/UEV1A to catalyze the synthesis of unique polyubiquitin chains linked through lysine-63 (K63) of ubiquitin. Blockade of this polyubiquitin chain synthesis, but not inhibition of the proteasome, prevents the activation of IKK by TRAF6. These results unveil a new regulatory function for ubiquitin, in which IKK is activated through the assembly of K63-linked polyubiquitin chains.









Primary Antibodies
Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
---|---|---|---|---|---|---|---|
TA306184 | UBE2V1 / CROC1 antibody |
||||||
Rabbit Polyclonal UEV1A Antibody | |||||||
![]() |
Rabbit | IgG | Purified | Hu, Ms, Rt | E, WB |
0.1 mg /
€415.00
|
|
OriGene Technologies, Inc. | |||||||
AP05250PU-N | UBE2V1 / CROC1 antibody |
||||||
![]() |
Rabbit | IgG | Purified | Hu, Ms, Rt | WB |
0.1 mg /
€600.00
|
|
OriGene Technologies GmbH | |||||||
AP08483PU-N | UBE2V1 / CROC1 (31-49) antibody |
||||||
![]() |
Rabbit | IgG | Aff - Purified | Hu | P, WB |
50 µg /
€425.00
|
|
OriGene Technologies GmbH | |||||||
AP12060PU-N | UBE2V1 / CROC1 (C-term, Isoform 3) antibody |
||||||
![]() |
Rabbit | Ig | Purified | Hu | WB |
0.4 ml /
€415.00
|
|
OriGene Technologies GmbH |
Proteins & Growth Factors
Catalog No. | Species | Pres. | Purity | Source | |
---|---|---|---|---|---|
TP301824 | UBE2V1 / CROC1 (transcript variant 4) |
||||
Recombinant protein of human ubiquitin-conjugating enzyme E2 variant 1 (UBE2V1), transcript variant 4 | |||||
![]() |
Human | > 80 % Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps. Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining. |
HEK293 cells |
20 µg /
€748.00
|
|
OriGene Technologies, Inc. | |||||
TP323133 | UBE2V1 / CROC1 (transcript variant 1) |
||||
Recombinant protein of human TMEM189-UBE2V1 readthrough transcript (TMEM189-UBE2V1), transcript variant 1 | |||||
![]() |
Human | > 80 % Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps. Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining. |
HEK293 cells |
20 µg /
€748.00
|
|
OriGene Technologies, Inc. |
Lysates
Catalog No. | ||
---|---|---|
LY422298 | UBE2V1 overexpression lysate |
|
![]() |
0.1 mg /
€295.00
|
|
OriGene Technologies, Inc. |
Human Lenti ORF Particles
Catalog No. | ||
---|---|---|
RC223031L2V | Lenti ORF particles, UBE2V1 (mGFP-tagged)-Human ubiquitin-conjugating enzyme E2 variant 1 (UBE2V1), transcript variant 2, 200 uL, >10^7 TU/mL |
|
![]() |
200 µl /
€930.00
|
|
OriGene Technologies, Inc. | ||
RC222103L2V | Lenti ORF particles, UBE2V1 (mGFP-tagged)-Human ubiquitin-conjugating enzyme E2 variant 1 (UBE2V1), transcript variant 3, 200 uL, >10^7 TU/mL |
|
![]() |
200 µl /
€930.00
|
|
OriGene Technologies, Inc. | ||
RC223031L1V | Lenti ORF particles, UBE2V1 (Myc-DDK-tagged)-Human ubiquitin-conjugating enzyme E2 variant 1 (UBE2V1), transcript variant 2, 200 uL, >10^7 TU/mL |
|
![]() |
200 µl /
€830.00
|
|
OriGene Technologies, Inc. | ||
RC222103L1V | Lenti ORF particles, UBE2V1 (Myc-DDK-tagged)-Human ubiquitin-conjugating enzyme E2 variant 1 (UBE2V1), transcript variant 3, 200 uL, >10^7 TU/mL |
|
![]() |
200 µl /
€830.00
|
|
OriGene Technologies, Inc. | ||
Mouse Lenti ORF Particles
Catalog No. | ||
---|---|---|
MR200994L2V | Lenti ORF particles, Ube2v1 (GFP-tagged) - Mouse ubiquitin-conjugating enzyme E2 variant 1 (Ube2v1), 200 uL, >10^7 TU/mL |
|
![]() |
200 µl /
€930.00
|
|
OriGene Technologies, Inc. | ||
MR200994L1V | Lenti ORF particles, Ube2v1 (Myc-DDK-tagged) - Mouse ubiquitin-conjugating enzyme E2 variant 1 (Ube2v1), 200 uL, >10^7 TU/mL |
|
![]() |
200 µl /
€830.00
|
|
OriGene Technologies, Inc. | ||