UBE2V1 / CROC1 antibody

Principal name

UBE2V1 / CROC1 antibody

Alternative names for UBE2V1 / CROC1 antibody

Ubiquitin-conjugating enzyme E2 variant 1, UEV-1, UEV1, UBE2V, CROC-1, P/OKcl.19, TRAF6-regulated IKK activator 1 beta Uev1A

SwissProt ID

Q13404 (Human), Q3SZ52 (Bovin), Q90879 (Chick), Q9CZY3 (Mouse)

Gene ID

387522 (TMEM189-UBE2V1), 7335 (UBE2V1), 66589 (Ube2v1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)

Background of UBE2V1 / CROC1 antibody

The CROC1 isoforms, also known as UBE2V1, show sequence similarity to ubiquitin-conjugating enzymes (UBCs, or E2s) but lack the conserved cysteine residue critical to catalytic activity of E2s.1 Northern blot analysis detected approximately 2.1- and 2.5-kb CROC1 transcripts in all human tissues examined, with the highest levels in brain, skeletal muscle, and kidney. Partial human intestinal epithelial cell cDNAs have been isolated containing the 3-primecoding sequence and 3-prime untranslated region of UBE2V1, also called UEV1.2 UEV1 does not have ubiquitin-conjugating activity in vitro. UEV1 transcripts are downregulated upon differentiation of a colon carcinoma cell line.1 Constitutive expression of exogenous UEV1 protein in these colon carcinoma cells inhibits their capacity to differentiate upon confluence and induces changes in cell cycle behavior associated with inhibition of CDK1. A heterodimeric protein complex has been identified that links TRAF6 to IKK activation.3 Peptide mass fingerprinting analysis revealed that this complex is composed of the ubiquitin conjugating enzyme UBC13 and the UBC-like protein UBE2V1, also called UEV1A. TRAF6, a RING domain protein, functions together with UBC13/UEV1A to catalyze the synthesis of unique polyubiquitin chains linked through lysine-63 (K63) of ubiquitin. Blockade of this polyubiquitin chain synthesis, but not inhibition of the proteasome, prevents the activation of IKK by TRAF6. These results unveil a new regulatory function for ubiquitin, in which IKK is activated through the assembly of K63-linked polyubiquitin chains.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

UBE2V1 / CROC1 antibody

  Rabbit Polyclonal UEV1A Antibody  
Western blot analysis of UEV1A in Jurkat cell lysates with UEV1A antibody at (A) 1, (B) 2, and (C) 4 µg/ml. Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

UBE2V1 / CROC1 antibody

Western blot analysis of UEV1A in Jurkat cell lysates with UEV1A antibody at (A) 1, (B) 2, and (C) 4 µg/ml Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €440.00
  Acris Antibodies GmbH

UBE2V1 / CROC1 (31-49) antibody

Thyroid: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hu P, WB
50 µg / €470.00
  Acris Antibodies GmbH

UBE2V1 / CROC1 (C-term, Isoform 3) antibody

Western Blot analysis of UBE2V1 (C-term) Pab (Cat.#AP12060PU-N) to detect UBE2V1 in 293 cell lysate. Rabbit Ig Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

UBE2V1 / CROC1 antibody

Immunofluorescence of purified MaxPab antibody to UBE2V1 on HeLa cell. [antibody concentration 10 ug/ml] Mouse Serum Hu E(detection), ICC/IF, WB
50 µl / €370.00
  Abnova Taiwan Corp.

UBE2V1 / CROC1 antibody

UBE2V1 MaxPab polyclonal antibody. Western Blot analysis of UBE2V1 expression in human kidney. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

UBE2V1 / CROC1 antibody

UBE2V1 / CROC1 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

UBE2V1 / CROC1 antibody

Western blot analysis of UBE2V1 in Jurkat cell lysate. Using UBE2V1 polyclonal antibody ( Cat # PAB0335 ) at 1 µg/ml. Rabbit Hu WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

UBE2V1 / CROC1 antibody

The UBE2V1 polyclonal antibody ( Cat # PAB4226 ) is used in Western blot to detect UBE2V1 in 293 cell lysate . Rabbit Hu, Ms E, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

UBE2V1 / CROC1 antibody

UBE2V1 / CROC1 Goat Hu E
0.1 mg / €390.00
  Abnova Taiwan Corp.

UBE2V1 / CROC1 (C-term) antibody

Human Fetal Brain; WB Suggested Anti-UBE2V1 Antibody. . Titration: 1.0 ug/ml. . Positive Control: Fetal Brain; UBE2V1 antibody - C-terminal region (ARP61716_P050) in Human Fetal Brain cells using Western Blot Rabbit Aff - Purified Hu
50 µg / €350.00
  AVIVA Systems Biology

CRISPR

Catalog No. Species Donor Vector  

UBE2V1 - human gene knockout kit via CRISPR

UBE2V1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

UBE2V1 - human gene knockout kit via CRISPR

UBE2V1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

UBE2V1 - human gene knockout kit via CRISPR

UBE2V1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

UBE2V1 - human gene knockout kit via CRISPR

UBE2V1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Ube2v1 - mouse gene knockout kit via CRISPR

Ube2v1 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Ube2v1 - mouse gene knockout kit via CRISPR

Ube2v1 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Ube2v1 - mouse gene knockout kit via CRISPR

Ube2v1 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Ube2v1 - mouse gene knockout kit via CRISPR

Ube2v1 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

UBE2V1 / CROC1 (transcript variant 4)

  Recombinant protein of human ubiquitin-conjugating enzyme E2 variant 1 (UBE2V1), transcript variant 4  
UBE2V1 / CROC1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

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