UBE3A antibody

Principal name

UBE3A antibody

Alternative names for UBE3A antibody

Ubiquitin-protein ligase E3A, E6AP, EPVE6AP, HPVE6A, NY-REN-54, Oncogenic protein-associated protein E6-AP, Human papillomavirus E6-associated protein

SwissProt ID

O08759 (Mouse), Q05086 (Human)

Gene ID

7337 (UBE3A)

Available reactivities

Hu (Human), Ms (Mouse), Bov (Bovine), Dros (Drosophila), Rt (Rat), Ze (Zebrafish), African clawed frog

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunoprecipitation (IP)

Background of UBE3A antibody

UBE3A interacts with the E6 protein of the cancer-associated human papillomavirus types 16 and 18. The E6/E6-AP complex binds to and targets the p53 tumor-suppressor protein for ubiquitin-mediated proteolysis. It is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It can target itself for ubiquitination in vitro and efficiently promotes its own degradation in vivo. It appears that only unmodified E6-AP molecules can bind efficiently to p53 in the presence of the HPV E6 oncoprotein. UBE3A binds UBQLN1 and UBQLN2. Defects in UBE3A are a cause of Angelman syndrome (AS) [MIM:105830]; also known as 'happy puppet syndrome'. AS is characterized by features of severe motor and intellectual retardation, microcephaly, ataxia, frequent jerky limb movements and flapping of the arms and hands, hypotonia, hyperactivity, hypopigmentation, seizures, absence of speech, frequent smiling and episodes of paroxysmal laughter, and an unusual facies characterized by macrostomia, a large mandible and open-mouthed expression, a great propensity for protruding the tongue ('tongue thrusting'), and an occipital groove. UBE3A contains 1 HECT-type E3 ubiquitin-protein ligase domain.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

UBE3A (C-term) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

UBE3A (transcript variant 3)

  Purified recombinant protein of Homo sapiens ubiquitin protein ligase E3A (UBE3A), transcript variant 3  
UBE3A Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

UBE3A (transcript variant 2)

  Recombinant protein of human ubiquitin protein ligase E3A (UBE3A), transcript variant 2  
UBE3A Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, UBE3A (mGFP-tagged) - Human ubiquitin protein ligase E3A (UBE3A), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, UBE3A (mGFP-tagged) - Human ubiquitin protein ligase E3A (UBE3A), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, UBE3A (mGFP-tagged) - Human ubiquitin protein ligase E3A (UBE3A), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, UBE3A (mGFP-tagged) - Human ubiquitin protein ligase E3A (UBE3A), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,840.00
  OriGene Technologies, Inc.

Lenti ORF particles, UBE3A (Myc-DDK tagged) - Human ubiquitin protein ligase E3A (UBE3A), transcript variant 1 , 200 uL, >10^7 TU/mL

Lenti ORF particles, UBE3A (Myc-DDK tagged) - Human ubiquitin protein ligase E3A (UBE3A), transcript variant 1 , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Lenti ORF particles, UBE3A (Myc-DDK tagged) - Human ubiquitin protein ligase E3A (UBE3A), transcript variant 2 , 200 uL, >10^7 TU/mL

Lenti ORF particles, UBE3A (Myc-DDK tagged) - Human ubiquitin protein ligase E3A (UBE3A), transcript variant 2 , 200 uL, >10^7 TU/mL  
200 µl / €1,660.00
  OriGene Technologies, Inc.

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