Ubiquilin-1 (UBQLN1) antibody

Principal name

Ubiquilin-1 (UBQLN1) antibody

Alternative names for Ubiquilin-1 (UBQLN1) antibody

PLIC1, PLIC-1, DA41, Protein linking IAP with cytoskeleton 1

SwissProt ID

Q8R317 (Mouse), Q9JJP9 (Rat), Q9UMX0 (Human)

Gene ID

29979 (UBQLN1), 56085 (Ubqln1), 114590

Available reactivities

Hu (Human), Ms (Mouse), Bov (Bovine), Can (Canine), Chk (Chicken), Rt (Rat), Ze (Zebrafish), Eq (Equine), Por (Porcine), Rb (Rabbit), Sh (Sheep)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of Ubiquilin-1 (UBQLN1) antibody

Ubiquilin 1 (UBQLN1), also known as DA41, was isolated from an adult rat lung cDNA library, and encodes a cellular protein that associates with DAN.1 DAN expression is reduced in rat fibroblast 3Y1 cells transformed with mouse sarcoma virus and in rodent fibroblasts transformed with a variety of oncogenes. The DAN-DA41 interaction is mediated through the N-terminal domain and a cysteine-knot region of DAN. Human DA41 encodes a 589-amino acid protein with 86% amino acid sequence identity with rat protein.2 DA41 expression is regulated in a cell cycle-dependent manner. PLIC1 and PLIC2 (UBQLN2) are homologs of the mouse Plics (proteins linking integrin-associated protein (IAP) and cytoskeleton) and the yeast Dsk2 protein. PLIC1, also called UBQLN1, shares 72% amino acid identity with PLIC2,3 Two motifs are conserved in the mammalian PLICs and yeast Dsk2, an N-terminal ubiquitin-like (UBL) domain and a C-terminal ubiquitin-associated (UBA) domain. Unlike ubiquitin, the UBL domain of the PLICs does not have a diglycine motif in its C terminus. The UBA domain is present in multiple enzyme classes of the ubiquitination machinery. Human PLICs associate with both proteasomes and ubiquitin ligases in large complexes. Overexpression of PLICs impairs the in vivo degradation of 2 unrelated ubiquitin-dependent proteasome substrates, p53 and I-kappa-B-alpha (NFKBIA), but not a ubiquitin-independent substrate. PLICs may link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. The DA41 gene maps to chromosome 9q21.2-q21.3, a position overlapping a candidate tumor suppressor locus for bladder cancer.2

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Ubiquilin-1 (UBQLN1) antibody

  Rabbit Polyclonal Anti-UBQLN1 Antibody  
WB Suggested Anti-UBQLN1 Antibody Titration: 1 ug/ml; Positive Control: 293T cells lysate Rabbit IgG Purified Bov, Can, Eq, Hu, Por, Rb, Rt, Sh P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

Ubiquilin-1 (UBQLN1) (N-term) antibody

  Rabbit Polyclonal Antibody against UBQLN1 (N-term)  
Western blot analysis of anti-Ubiquilin1 Antibody (N-term) (Cat.#TA302118) pre-incubated with and without blocking peptide (BP2176a) in Jurkat cell line lysate. Ubiquilin1 (arrow) was detected using the purified Pab. Rabbit Ig Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Ubiquilin-1 (UBQLN1) (Center) antibody

  Rabbit Polyclonal Antibody against UBQLN1 (Center)  
Ubiquilin1 Antibody (P311) (Cat.# TA302119) western blot analysis in SH-SY5Y cell line lysates (35ug/lane).This demonstrates the Ubiquilin1 antibody detected the Ubiquilin1 protein (arrow). Rabbit Ig Purified Hu, Ms P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Ubiquilin-1 (UBQLN1) antibody

  Rabbit polyclonal antibody to Ubiquilin-1 (ubiquilin 1)  
Sample (30 ug of whole cell lysate). A: 293T. 7.5% SDS PAGE. TA308768 diluted at 1:1000. Rabbit IgG Aff - Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Ubiquilin-1 (UBQLN1) (N-term) antibody

  Rabbit polyclonal Ubiquilin1 (PLIC1) Antibody (N-term)  
PLIC1 Antibody (P34) (Cat.# TA324714) western blot analysis in SH-SY5Y,U87-MG cell line lysates (35ug/lane).This demonstrates the PLIC1 antibody detected the PLIC1 protein (arrow). Rabbit Ig Purified Hu, Ms P, WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

CRISPR

Catalog No. Species Donor Vector  

UBQLN1 - human gene knockout kit via CRISPR

UBQLN1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

UBQLN1 - human gene knockout kit via CRISPR

UBQLN1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

UBQLN1 - human gene knockout kit via CRISPR

UBQLN1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

UBQLN1 - human gene knockout kit via CRISPR

UBQLN1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Ubqln1 - mouse gene knockout kit via CRISPR

Ubqln1 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Ubqln1 - mouse gene knockout kit via CRISPR

Ubqln1 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Ubqln1 - mouse gene knockout kit via CRISPR

Ubqln1 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Ubqln1 - mouse gene knockout kit via CRISPR

Ubqln1 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Ubiquilin-1 (UBQLN1) (transcript variant 2)

  Recombinant protein of human ubiquilin 1 (UBQLN1), transcript variant 2  
Ubiquilin-1 (UBQLN1) Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

Ubiquilin-1 (UBQLN1) (transcript variant 1)

  Recombinant protein of human ubiquilin 1 (UBQLN1), transcript variant 1  
Ubiquilin-1 (UBQLN1) Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, UBQLN1 (mGFP-tagged) - Human ubiquilin 1 (UBQLN1), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, UBQLN1 (mGFP-tagged) - Human ubiquilin 1 (UBQLN1), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, UBQLN1 (mGFP-tagged) - Human ubiquilin 1 (UBQLN1), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, UBQLN1 (mGFP-tagged) - Human ubiquilin 1 (UBQLN1), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, UBQLN1 (Myc-DDK tagged) - Human ubiquilin 1 (UBQLN1), transcript variant 1 , 200 uL, >10^7 TU/mL

Lenti ORF particles, UBQLN1 (Myc-DDK tagged) - Human ubiquilin 1 (UBQLN1), transcript variant 1 , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Lenti ORF particles, UBQLN1 (Myc-DDK tagged) - Human ubiquilin 1 (UBQLN1), transcript variant 2 , 200 uL, >10^7 TU/mL

Lenti ORF particles, UBQLN1 (Myc-DDK tagged) - Human ubiquilin 1 (UBQLN1), transcript variant 2 , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Ubqln1 (GFP-tagged) - Mouse ubiquilin 1 (Ubqln1), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, Ubqln1 (GFP-tagged) - Mouse ubiquilin 1 (Ubqln1), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,230.00
  OriGene Technologies, Inc.

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