Ubiquilin-1 (UBQLN1) antibody

Principal name

Ubiquilin-1 (UBQLN1) antibody

Alternative names for Ubiquilin-1 (UBQLN1) antibody

PLIC1, PLIC-1, DA41, Protein linking IAP with cytoskeleton 1

SwissProt ID

Q8R317 (Mouse), Q9JJP9 (Rat), Q9UMX0 (Human)

Gene ID

29979 (UBQLN1)

Available reactivities

Hst (Hamster), Hu (Human), Bov (Bovine), Chk (Chicken), Dros (Drosophila), Mam (Mammalia), Broad, Br, Ms (Mouse), Can (Canine), Rt (Rat), Ze (Zebrafish), Eq (Equine), Por (Porcine), Rb (Rabbit), Sh (Sheep)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Frozen Sections (C), Immunoprecipitation (IP)

Background of Ubiquilin-1 (UBQLN1) antibody

Amyloid beta peptide is the major constituent of amyloid plaques in the brains of individuals afflicted with Alzheimer's disease. This peptide is generated from the beta-amyloid precursor protein (beta APP) in a two-step process. The first step involves cleavage of the extracellular, amino-terminal domain of beta APP. Protein cleavage is performed by an aspartyl protease termed beta-secretase (BACE). This enzyme is synthesized as a propeptide that must be modified to the mature and active form by the prohormone convertase, furin. Beta APP cleavage by the mature form of BACE results in the cellular secretion of a segment of beta APP and a membrane-bound remnant. This remnant is then processed by another protease termed gamma-secretase. Gamma-secretase cleaves an intra-membrane site in the carboxyl-terminal domain of beta APP, thus generating the amyloid beta peptide. Gamma-secretase is believed to be a multi-subunit complex containing presenilin-1 and 2 as central components. Found associated with the presenilins are nicastrin and ubiquilin. Nicastrin has been found to bind to the carboxyl-terminus of beta APP and helps to modulate the production of the amyloid beta peptide. Ubiquilin is believed to promote presenilin protein accumulation.
Also found in the neurofibrillary lesions associated with Alzheimer's disease is a protein termed Tau. Tau is a neuronal microtubule-associated protein found predominantly on axons. Tau functions to promote tubulin polymerization and stabilize microtubules. Tau, in its hyperphosphorylated form, is the major constituent of paired helical filaments (PHF), which are the building block of neurofibrillary lesions found in brain tissue of Alzheimer's diseased patients.

General readings

General / background references:Conklin D et al. Molecular cloning, chromosome mapping and characterization of UBQLN3 a testis-specific gene that contains an ubiquitin-like domain. Gene 249:91-8 (2000). PubMed PMID: 10831842
Mah AL et al. Identification of ubiquilin, a novel presenilin interactor that increases presenilin protein accumulation. J Cell Biol 151:847-62 (2000). PubMed PMID: 11076969

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Ubiquilin-1 (UBQLN1) antibody

WB Suggested Anti-UBQLN1 Antibody Titration: 1 ug/ml; Positive Control: 293T cells lysate Rabbit IgG Purified Bov, Can, Eq, Hu, Por, Rb, Rt, Sh P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

Ubiquilin-1 (UBQLN1) antibody

Human Lung; UBQLN1 antibody - middle region (ARP54958_P050) in Human Lung cells using Immunohistochemistry Rabbit Aff - Purified Bov, Can, Chk, Hu, Ms, Rt, Ze P, WB
50 µg / €350.00
  AVIVA Systems Biology

Ubiquilin-1 (UBQLN1) (N-term) antibody

Western blot analysis of anti-Ubiquilin1 Antibody (N-term) (Cat.#TA302118) pre-incubated with and without blocking peptide (BP2176a) in Jurkat cell line lysate. Ubiquilin1 (arrow) was detected using the purified Pab. Rabbit Ig Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Ubiquilin-1 (UBQLN1) (Center) antibody

Ubiquilin1 Antibody (P311) (Cat.# TA302119) western blot analysis in SH-SY5Y cell line lysates (35ug/lane).This demonstrates the Ubiquilin1 antibody detected the Ubiquilin1 protein (arrow). Rabbit Ig Purified Hu, Ms P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Ubiquilin-1 (UBQLN1) antibody

Sample (30 ug of whole cell lysate). A: 293T. 7.5% SDS PAGE. TA308768 diluted at 1:1000. Rabbit IgG Aff - Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Ubiquilin-1 (UBQLN1) (N-term) antibody

PLIC1 Antibody (P34) (Cat.# TA324714) western blot analysis in SH-SY5Y,U87-MG cell line lysates (35ug/lane).This demonstrates the PLIC1 antibody detected the PLIC1 protein (arrow). Rabbit Ig Purified Hu, Ms P, WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

Ubiquilin-1 (UBQLN1) antibody

Ubiquilin-1 (UBQLN1) Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

Ubiquilin-1 (UBQLN1) antibody

Immunofluorescence of monoclonal antibody to UBQLN1 on HeLa cell . [antibody concentration 10 ug/ml] Mouse IgG1 1C6-A3 Purified Hu E, ICC/IF, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Ubiquilin-1 (UBQLN1) antibody

Ubiquilin-1 (UBQLN1) Mouse IgG1 1C6-B7 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Ubiquilin-1 (UBQLN1) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with UBQLN1 polyclonal antibody ( Cat # PAB1740 ) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma. Rabbit Hu, Ms E, P, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

Ubiquilin-1 (UBQLN1) antibody

The UBQLN1 polyclonal antibody ( Cat # PAB4235 ) is used in Western blot to detect UBQLN1 in mouse cerebellum tissue lysate . Rabbit Hu, Ms E, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

Ubiquilin-1 (UBQLN1) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with UBQLN1 polyclonal antibody ( Cat # PAB4236 ) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining . This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated . BC = breast carcinoma . Rabbit Hu, Ms E, P, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

Ubiquilin-1 (UBQLN1) antibody

Western Blot: Ubiquilin 1  Antibody [NB120-3341] - Figure 1 shows a Western blot of Ubiquilin 1  on CHO cell extract using NB120-3341. Rabbit IgG Aff - Purified Ms WB
0.1 mg / €400.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Ubiquilin-1 (UBQLN1) (transcript variant 2)

Ubiquilin-1 (UBQLN1) Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

Ubiquilin-1 (UBQLN1) (transcript variant 1)

Ubiquilin-1 (UBQLN1) Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Ubiquilin-1 (UBQLN1)

Ubiquilin-1 (UBQLN1) Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

Ubiquilin-1 (UBQLN1)

Ubiquilin-1 (UBQLN1) Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

17 Item(s)

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