Ubiquilin-2 (UBQLN2) antibody

Principal name

Ubiquilin-2 (UBQLN2) antibody

Alternative names for Ubiquilin-2 (UBQLN2) antibody

PLIC2, PLIC-2, N4BP4, Chap1, DSK2 homolog, HRIHFB2157, Protein linking IAP with cytoskeleton 2, Ubiquitin-like product Chap1/Dsk2

SwissProt ID

Q9QZM0 (Mouse), Q9UHD9 (Human)

Gene ID

29978 (UBQLN2), 54609 (Ubqln2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of Ubiquilin-2 (UBQLN2) antibody

Ubiquilin 2, also known as PLIC2 and Chap1, is a member of the ubiquilin protein family, which regulate the degradation of cellular proteins through proteasome or autophage-like pathways. Humans have four ubiquilin genes, each encoding a separate protein referred to as Ubiquilin 1, 2, 3 and 4. All ubiquilins contain an N-termil ubiquitin-like (UBL) domain and a C-termil ubiquitin-associated (UBA) domain, while the central part of the molecules are highly variable. The UBL domains bind subunits of the proteasome, and the UBA domains binds to polyubiquitin chains that are typically conjugated onto proteins marked for proteosomal degradation. Ubiquilin 2 has a unique region close to the C terminus containing 12 PXX tandem collagen like repeats, where P is proline and X is most cases valine, glycine, isoleucine or threonine. Teepu Siddique and his collaborators have identified mutations in the ubiquilin 2 gene leading to protein point mutations which were important contributors to several forms of amyotrophic lateral sclerosis (ALS) and Frontotemporal lobar degeneration (FTLD). Interestingly, these mutations involved alterations in proline residues in the PXX repeat region (P497H, P497S, P506T, P509S and P525S). Recently, the Lee and Trojanowski group investigated C9orf72 hexanucleotide expansion and ubiquilin 2 pathology in patients with ALS and FTLD by genetic alysis and immunohistochemistry and found distinct Ubiquilin 2 pathology in ALS and FTLD-TDP with C9orf72 expansion. C9orf72 hexonucleotide expansion is the most common cause to date of familial ALS and FTLD. Ubiquilin 2 protein is of different molecular size in mouse and human, 638 and 624 amino acids respectively. As a result the mouse protein, endogenously expressed in rodent 3T3 cells, runs on SDS-PAGE and western blots slightly slower than the human protein.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Ubiquilin-1 / Ubiquilin-2 (N-term) antibody

(LEFT) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. (RIGHT) Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with Dsk2 Antibody (N-term) (Cat.#AP12092PU-N), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Ubiquilin-2 (UBQLN2) antibody

  Mouse Monoclonal Ubiquilin 2 Antibody (6H9)  
Western Blot: Ubiquilin 2 Antibody (6H9) [TA337117] - Untransfected primary mouse neuron and glia cells (1), cells transduced with human Ubiquilin 2 wild type (2), with Ubiquilin 2 P506T mutant (3), with Ubiquilin 2 P497S mutant (4) and with GFP control ( Mouse IgG1 6H9 Purified Hu, Ms ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Ubiquilin-2 (UBQLN2) antibody

  Rabbit Polyclonal Anti-UBQLN2 Antibody  
WB Suggested Anti-UBQLN2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:1562500; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, GP, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

Ubiquilin-2 (UBQLN2) (C-term) antibody

Western blot analysis of anti-Dsk2 Pab (C-term) (Cat. #AP12093PU-N) to detect Dsk2 in HeLa cell lysate. Rabbit Ig Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Ubiquilin-2 (UBQLN2) antibody

HeLa cells staing with Ubiquilin 2 (green), and counterstained with chicken polyclonal Vimentin antibody to (red) and DNA (blue). The antibody reveals strong nuclear lamina staining, while the Vimentin antibody reveals cytoplasmic intermediate filaments. Protocol on datasheet. Mouse IgG1 Aff - Purified Hu, Ms ICC/IF, WB
0.1 ml / €380.00
  Neuromics Antibodies

CRISPR

Catalog No. Species Donor Vector  

UBQLN2 - human gene knockout kit via CRISPR

UBQLN2 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

UBQLN2 - human gene knockout kit via CRISPR

UBQLN2 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

UBQLN2 - human gene knockout kit via CRISPR

UBQLN2 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

UBQLN2 - human gene knockout kit via CRISPR

UBQLN2 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Ubqln2 - mouse gene knockout kit via CRISPR

Ubqln2 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Ubqln2 - mouse gene knockout kit via CRISPR

Ubqln2 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Ubqln2 - mouse gene knockout kit via CRISPR

Ubqln2 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

UBQLN2 overexpression lysate

UBQLN2 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, UBQLN2 (mGFP-tagged)-Human ubiquilin 2 (UBQLN2), 200 uL, >10^7 TU/mL

Lenti ORF particles, UBQLN2 (mGFP-tagged)-Human ubiquilin 2 (UBQLN2), 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, UBQLN2 (Myc-DDK-tagged)-Human ubiquilin 2 (UBQLN2), 200 uL, >10^7 TU/mL

Lenti ORF particles, UBQLN2 (Myc-DDK-tagged)-Human ubiquilin 2 (UBQLN2), 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Ubqln2 (GFP-tagged) - Mouse ubiquilin 2 (Ubqln2), 200 uL, >10^7 TU/mL

Lenti ORF particles, Ubqln2 (GFP-tagged) - Mouse ubiquilin 2 (Ubqln2), 200 uL, >10^7 TU/mL  
200 µl / €1,300.00
  OriGene Technologies, Inc.

Lenti ORF particles, Ubqln2 (Myc-DDK-tagged) - Mouse ubiquilin 2 (Ubqln2), 200 uL, >10^7 TU/mL

Lenti ORF particles, Ubqln2 (Myc-DDK-tagged) - Mouse ubiquilin 2 (Ubqln2), 200 uL, >10^7 TU/mL  
200 µl / €1,170.00
  OriGene Technologies, Inc.

17 Item(s)

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