Ubiquilin-2 (UBQLN2) antibody

Principal name

Ubiquilin-2 (UBQLN2) antibody

Alternative names for Ubiquilin-2 (UBQLN2) antibody

PLIC2, PLIC-2, N4BP4, Chap1, DSK2 homolog, HRIHFB2157, Protein linking IAP with cytoskeleton 2, Ubiquitin-like product Chap1/Dsk2

SwissProt ID

Q9QZM0 (Mouse), Q9UHD9 (Human)

Gene ID

29978 (UBQLN2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of Ubiquilin-2 (UBQLN2) antibody

Ubiquilin 2, also known as PLIC2 and Chap1, is a member of the ubiquilin protein family, which regulate the degradation of cellular proteins through proteasome or autophage-like pathways. Humans have four ubiquilin genes, each encoding a separate protein referred to as Ubiquilin 1, 2, 3 and 4. All ubiquilins contain an N-termil ubiquitin-like (UBL) domain and a C-termil ubiquitin-associated (UBA) domain, while the central part of the molecules are highly variable. The UBL domains bind subunits of the proteasome, and the UBA domains binds to polyubiquitin chains that are typically conjugated onto proteins marked for proteosomal degradation. Ubiquilin 2 has a unique region close to the C terminus containing 12 PXX tandem collagen like repeats, where P is proline and X is most cases valine, glycine, isoleucine or threonine. Teepu Siddique and his collaborators have identified mutations in the ubiquilin 2 gene leading to protein point mutations which were important contributors to several forms of amyotrophic lateral sclerosis (ALS) and Frontotemporal lobar degeneration (FTLD). Interestingly, these mutations involved alterations in proline residues in the PXX repeat region (P497H, P497S, P506T, P509S and P525S). Recently, the Lee and Trojanowski group investigated C9orf72 hexanucleotide expansion and ubiquilin 2 pathology in patients with ALS and FTLD by genetic alysis and immunohistochemistry and found distinct Ubiquilin 2 pathology in ALS and FTLD-TDP with C9orf72 expansion. C9orf72 hexonucleotide expansion is the most common cause to date of familial ALS and FTLD. Ubiquilin 2 protein is of different molecular size in mouse and human, 638 and 624 amino acids respectively. As a result the mouse protein, endogenously expressed in rodent 3T3 cells, runs on SDS-PAGE and western blots slightly slower than the human protein.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Ubiquilin-1 / Ubiquilin-2 (N-term) antibody

(LEFT) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. (RIGHT) Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with Dsk2 Antibody (N-term) (Cat.#AP12092PU-N), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Ubiquilin-2 (UBQLN2) antibody

Immunofluorescence of monoclonal antibody to UBQLN2 on A-431 cell. [antibody concentration 10 ug/ml] Mouse IgG2a 5F5 Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Ubiquilin-2 (UBQLN2) antibody

Western Blot: Ubiquilin 2 Antibody (6H9) [TA337117] - Untransfected primary mouse neuron and glia cells (1), cells transduced with human Ubiquilin 2 wild type (2), with Ubiquilin 2 P506T mutant (3), with Ubiquilin 2 P497S mutant (4) and with GFP control ( Mouse IgG1 6H9 Purified Hu, Ms ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Ubiquilin-2 (UBQLN2) antibody

WB Suggested Anti-UBQLN2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:1562500; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, GP, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

Ubiquilin-2 (UBQLN2) (C-term) antibody

Western blot analysis of anti-Dsk2 Pab (C-term) (Cat. #AP12093PU-N) to detect Dsk2 in HeLa cell lysate. Rabbit Ig Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Ubiquilin-2 (UBQLN2) antibody

UBQLN2 polyclonal antibody (A01), Lot # 061101JCS1 Western Blot analysis of UBQLN2 expression in Jurkat ( Cat # L017V1 ). Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

Ubiquilin-2 (UBQLN2) antibody

The UBQLN2 polyclonal antibody ( Cat # PAB1699 ) is used in Western blot to detect UBQLN2 in HeLa cell lysate. Rabbit Hu E, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

Ubiquilin-2 (UBQLN2) antibody

Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with UBQLN2 polyclonal antibody ( Cat # PAB1700 ) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Hu E, P, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

Ubiquilin-2 (UBQLN2) (N-term) antibody

Ubiquilin-2 (UBQLN2) Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

Ubiquilin-2 (UBQLN2) antibody

HeLa cells staing with Ubiquilin 2 (green), and counterstained with chicken polyclonal Vimentin antibody to (red) and DNA (blue). The antibody reveals strong nuclear lamina staining, while the Vimentin antibody reveals cytoplasmic intermediate filaments. Protocol on datasheet. Mouse IgG1 Aff - Purified Hu, Ms ICC/IF, WB
0.1 ml / €380.00
  Neuromics Antibodies

Ubiquilin-2 (UBQLN2) antibody

Ubiquilin-2 (UBQLN2) Rabbit Aff - Purified Hu WB
50 µg / €440.00
  Novus Biologicals Inc.

Ubiquilin-2 (UBQLN2) antibody

Immunohistochemistry-Paraffin: Ubiquilin 2 Antibody [NBP1-85639] - Immunohistochemical staining of human cerebellum shows strong nuclear and cytoplasmic positivity in purkinje cells, cells in molecular layer and cells in granular layer. Rabbit IgG Aff - Purified Hu ICC/IF, P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Ubiquilin-2 (UBQLN2)

Ubiquilin-2 (UBQLN2) Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

Ubiquilin-2 (UBQLN2)

Ubiquilin-2 (UBQLN2) Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Ubiquilin-2 (UBQLN2)

Ubiquilin-2 (UBQLN2) Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

Ubiquilin-2 (UBQLN2)

Ubiquilin-2 (UBQLN2) Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates (Overexpressed)

Catalog No.    

UBQLN2 overexpression lysate

UBQLN2 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

17 Item(s)

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