UBXN4 / UBXD2 antibody

Principal name

UBXN4 / UBXD2 antibody

Alternative names for UBXN4 / UBXD2 antibody

UBXDC1, KIAA0242, Erasin, UBX domain-containing protein 4, UBX domain-containing protein 2

SwissProt ID

Q3ZBU9 (Bovin), Q5HZY0 (Rat), Q8VCH8 (Mouse), Q92575 (Human)

Gene ID

23190 (UBXN4)

Available reactivities

Bov (Bovine), Can (Canine), Chk (Chicken), Hu (Human), Ms (Mouse), Rt (Rat), Ze (Zebrafish), African clawed frog, Xen (Xenopus), Eq (Equine), GP (Guinea Pig), Gt (Goat), Por (Porcine), Rb (Rabbit)

Available hosts

Rabbit

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of UBXN4 / UBXD2 antibody

Erasin is an endoplasmic reticulum (ER) and nuclear envelope membrane protein. Expressed in a variety of tissues, such as brain, placenta, heart, liver, prostate, kidney, pancreas, lung and skeletal muscle, erasin contains one UBX domain and participates in the clearing of ERAD (endoplasmic reticulum-associated protein degradation) substrates. The UBX domain of erasin is responsible for mediating its direct interaction with VCP (valosin-containing protein), an AAA-ATPase molecular chaperone. In response to ER stress, erasin expression is induced. The knockdown of erasin expression leads to the inhibition of ERAD, suggesting an important function of erasin in the ERAD pathway. In addition, erasin may be involved in Alzheimer’s disease, as it is known to accumulate in neurofibrillary degenerating neurons in patients with Alzheimer’s disease.

General readings

Ota,T., (2004) Nat. Genet. 36 (1), 40-45

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

UBXN4 / UBXD2 antibody

WB Suggested Antibody Titration: 2.5 ug/ml; Positive Control: HepG1.UBXN4 is strongly supported by BioGPS gene expression data to be expressed in Human HepG2 cells Rabbit IgG Purified Bov, Can, Eq, GP, Gt, Hu, Ms, Por, Rb, Rt, Ze P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

UBXN4 / UBXD2 antibody

Human kidney; UBXD2 antibody - middle region (ARP47620_T100) in Human kidney cells using Immunohistochemistry Rabbit Aff - Purified African clawed frog, Bov, Can, Chk, Hu, Ms, Rt, Ze P, WB
0.1 mg / €310.00
  AVIVA Systems Biology

UBXN4 / UBXD2 antibody

UBXN4 / UBXD2 Rabbit Purified Bov, Can, Chk, Hu, Ms, Rt, Xen, Ze P, WB
0.1 mg / €360.00
  Novus Biologicals Inc.

UBXN4 / UBXD2 antibody

Immunohistochemistry-Paraffin: UBXD2 Antibody [NBP1-92560] - Immunohistochemical staining of human colon shows strong cytoplasmic positivity in glandular cells. Rabbit IgG Aff - Purified Hu ICC/IF, P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

UBXN4 / UBXD2

UBXN4 / UBXD2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

UBXN4 / UBXD2

UBXN4 / UBXD2 Human in vitro transl.
2 µg / €300.00
  Abnova Taiwan Corp.

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