UCHL3 antibody

Principal name

UCHL3 antibody

Alternative names for UCHL3 antibody

UCH-L3, Ubiquitin thioesterase L3, Ubiquitin carboxyl-terminal hydrolase isozyme L3

SwissProt ID

P15374 (Human), Q06AB3 (Pig), Q2TBG8 (Bovin), Q91Y78 (Rat), Q9JKB1 (Mouse)

Gene ID

7347 (UCHL3), 50933 (Uchl3), 498560

Available reactivities

Hu (Human), Rt (Rat), Ms (Mouse), Bov (Bovine), Can (Canine), Chk (Chicken), Por (Porcine), Ze (Zebrafish), African clawed frog, Eq (Equine), GP (Guinea Pig), Rb (Rabbit), Ye (Yeast)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of UCHL3 antibody

Deubiquititing enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitited proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-termil glycine of either ubiquitin or NEDD8. Uchl3 has a 10-fold preference for Arg and Lys at position P3', and exhibits a preference towards 'Lys-48'-linked Ubiquitin chains. Uchl3 deubiquitites EC in apical compartments, thereby regulating apical membrane recycling. Uchl3 indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-sigling and insulin-induced adipogenesis. It is required for stress-response retil, skeletal muscle and germ cell maintence. Uchl3 may be involved in working memory and can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome.

General readings

Zhang Y., et al. (2000) J. Mol. Endocrinol. 25:221-228.
Zhang Y., et al. (2009) Mol Cell Endicrinol. 298(1-2):76-83.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

UCHL3 antibody

  Rabbit Polyclonal Anti-UCHL3 Antibody (C-Terminus)  
Anti-UCHL3 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Hu
50 µg / €400.00
  OriGene Technologies, Inc.

UCHL3 antibody

  Rabbit Polyclonal Anti-UCHL3 Antibody (Internal)  
Anti-UCHL3 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu, Ms, Rt P
50 µg / €400.00
  OriGene Technologies, Inc.

UCHL3 antibody

  Rabbit Polyclonal Anti-UCHL3 Antibody (Internal)  
Human Skeletal Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Aff - Purified Hu, Ms, Rt P
50 µg / €400.00
  OriGene Technologies, Inc.

UCHL3 antibody

  Rabbit Polyclonal Anti-UCHL3 Antibody  
WB Suggested Anti-UCHL3 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: Human Liver Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

UCHL3 antibody

  Rabbit Polyclonal Anti-UCHL3 Antibody  
Host: Rabbit; Target Name: Uchl3; Sample Tissue: Mouse Testis lysates; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ye WB
50 µg / €325.00
  OriGene Technologies, Inc.

UCHL3 antibody

  Rabbit Polyclonal Anti-UCHL3 Antibody - N-terminal region  
WB Suggested Anti-UCHL3 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:1562500; Positive Control: MCF7 cell lysate Rabbit IgG Purified Bov, Can, GP, Hu, Ms, Por, Rb, Rt, Ze P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

CRISPR

Catalog No. Species Donor Vector  

UCHL3 - human gene knockout kit via CRISPR

UCHL3 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

UCHL3 - human gene knockout kit via CRISPR

UCHL3 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

UCHL3 - human gene knockout kit via CRISPR

UCHL3 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

UCHL3 - human gene knockout kit via CRISPR

UCHL3 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Uchl3 - mouse gene knockout kit via CRISPR

Uchl3 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Uchl3 - mouse gene knockout kit via CRISPR

Uchl3 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Uchl3 - mouse gene knockout kit via CRISPR

Uchl3 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Uchl3 - mouse gene knockout kit via CRISPR

Uchl3 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

UCHL3

  Recombinant protein of human ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) (UCHL3)  
UCHL3 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

UCHL3

  Recombinant protein of human ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) (UCHL3)  
UCHL3 Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
E. coli
10 µg / €399.00
  OriGene Technologies, Inc.

UCHL3 (1-230, His-tag)

UCHL3 Human Purified > 95 % E. coli
0.5 mg / €750.00
  Acris Antibodies GmbH

UCHL3 (1-230, His-tag)

UCHL3 Human Purified > 95 % E. coli
0.1 mg / €300.00
  Acris Antibodies GmbH

Lysates

Catalog No.    

UCHL3 overexpression lysate

UCHL3 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, UCHL3 (mGFP-tagged) - Human ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) (UCHL3), 200 uL, >10^7 TU/mL

Lenti ORF particles, UCHL3 (mGFP-tagged) - Human ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) (UCHL3), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

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