UCMA antibody

Principal name

UCMA antibody

Alternative names for UCMA antibody

C10orf49, Unique cartilage matrix-associated protein

SwissProt ID

B9TQX4 (Rat), Q14BU0 (Mouse), Q6NWB6 (Danre), Q8WVF2 (Human)

Gene ID

221044 (UCMA)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P)

Background of UCMA antibody

UCMA is a secreted cartilage-specific protein that was discovered in a screen for differentially expressed genes in retinoic acid-treated mouse chondrocytes. It was also identified in a human chondrocyte EST screen for candidate genes of skeletal dysplasias. UCMA expression is thought to parallel that of collagen II with its expression decreasing with maturation chrondrocytes mature. UCMA is processed by a furin-like protease into two fragments, an amino-terminal fragment and a carboxy-terminal fragment (UCMA-C). Application of recombinant UCMA-C to primary osteoblasts, mesenchymal stem cells, and MC3T3-E1 pre-osteoblasts interferes with their osteogenic differentiation, but does not affect expression of chondrocyte-specific genes or chondrocyte proliferation, suggesting that UCMA may be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells. At least two isoforms of UCMA are known to exist.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

UCMA antibody

Western blot analysis of UCMA in SW1353 cell lysate with UCMA antibody at (A) 2.5 and (B) 5 µg/ml. Rabbit IgG Aff - Purified Hu, Ms E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

UCMA (C-term) antibody

Human Lung, Chondrocytes: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Purified Hu, Ms E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

UCMA Control Peptide

50 µg / €160.00
  Acris Antibodies GmbH

UCMA antibody

UCMA Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

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