Alternative names for UHRF1BP1 antibody
UHRF1-binding protein 1, C6orf107, ICBP90-binding protein 1, Ubiquitin-like containing PHD and RING finger domains 1-binding protein 1
Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Enzyme Immunoassay (E), Western blot / Immunoblot (WB)
Background of UHRF1BP1 antibody
UHRF1BP1 Antibody: The Ubiquitin-like containing PHD and RING finger domains 1-binding protein 1 (UHRF1BP1), also known as ICBP90, is a transcription and cell cycle regulator. It specifically binds to the histone H3 N-termil tail when methylated on K9 by two functiol domains, a PHD finger that defines the binding specificity and an SRA (SET- and RING-associated) domain that promotes binding activity. UHRF1BP1 is required for proper heterochromatin formation in mammalian cells. Furthermore, UHRF1BP1 is thought to be a pivotal target for the ERK1/2 sigling pathway to control the proliferation of Jurkat T cells.
Hopfner R, Mousli M, Jeltsch JM, et al.: ICBP90, a novel human CCAAT binding protein, involved in the regulation of Topoisomerase II α expression. Cancer Res.2000; 60:121-8.
|Rabbit||IgG||Aff - Purified||Hu, Ms||E, ICC/IF, P, WB||
0.1 mg / €325.00
|OriGene Technologies, Inc.|
|+2 additional images|
50 µg / €160.00
|Acris Antibodies GmbH|