ULK1 / ATG1 antibody

Principal name

ULK1 / ATG1 antibody

Alternative names for ULK1 / ATG1 antibody

KIAA0722, Unc-51-like kinase 1, Autophagy-related protein 1 homolog, Serine/threonine-protein kinase ULK1

SwissProt ID

O70405 (Mouse), O75385 (Human)

Gene ID

8408 (ULK1), 22241 (Ulk1)

Available reactivities

Hu (Human), Mky (Monkey), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Eq (Equine), Por (Porcine), Ze (Zebrafish), Prim (Primate)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Flow Cytometry (F)

Background of ULK1 / ATG1 antibody

Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). Two human homologs of the yeast autophagy-specific kinase exist: ULK1(APG1) and ULK2. APG1 plays a critical role in regulating key elements of the autophagy pathway. APG1 stimulates autophagy, leading to autophagy-dependent restriction of cell growth and ultimately cell apoptosis at high levels of activity, and is a negative regulator of mTOR signaling.

General readings

Greenman C., et.al., Nature 446:153-158 (2007).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ULK1 / ATG1 (649-679) antibody

  Rabbit polyclonal APG1 (ULK1) Antibody (Center)  
Western blot analysis of anti-ULK1 Pab (Cat. #TA325024) in A2058 cell lysate. ULK1 (arrow) was detected using purified Pab. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence. Rabbit Ig Aff - Purified Hu WB
0.4 ml / €415.00
  OriGene Technologies, Inc.

ULK1 / ATG1 (320-370) antibody

Kidney: Formalin-Fixed Paraffin Embedded (FFPE) Rabbit IgG Aff - Purified Hu, Mky P, WB
50 µg / €425.00
  OriGene Technologies GmbH

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