UNC13D antibody

Principal name

UNC13D antibody

Alternative names for UNC13D antibody

Protein unc-13 homolog D, Munc13-4

SwissProt ID

Q70J99 (Human), Q9R189 (Rat)

Gene ID

201294 (UNC13D), 192177 (Unc13d)

Available reactivities

Hu (Human), Ms (Mouse), Can (Canine), Rt (Rat), Bov (Bovine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Goat, Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of UNC13D antibody

This gene encodes a protein that is a member of the UNC13 family, containing similar domain structure as other family members but lacking an N-termil phorbol ester-binding C1 domain present in other Munc13 proteins. The protein appears to play a role in vesicle maturation during exocytosis and is involved in regulation of cytolytic granules secretion. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis type 3, a genetically heterogeneous, rare autosomal recessive disorder. [provided by RefSeq, Jul 2008].

General readings

1. Feldmann J, Callebaut I, Raposo G, Certain S, Bacq D, Dumont C, Lambert N, Ouachee-Chardin M, Chedeville G, Tamary H, Minard-Colin V, Vilmer E, Blanche S,
Le Deist F, Fischer A, de Saint Basile G.
Munc13-4 is essential for cytolytic granules fusion and is mutated in a form of familial hemophagocytic lymphohistiocytosis (FHL3). Cell. 2003 Nov 14;115(4):461-73.
PMID: 14622600

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

UNC13D antibody

  Rabbit Polyclonal antibody to UNC13D (unc-13 homolog D (C. elegans))  
Sample (30 ug of whole cell lysate). A: Jurkat. B: K562. 5% SDS PAGE. TA308332 diluted at 1:1000. Rabbit IgG Aff - Purified Hu ICC/IF, P, WB
0.1 ml / €415.00
  OriGene Technologies, Inc.

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