Uracil-DNA glycosylase (UNG) antibody

Principal name

Uracil-DNA glycosylase (UNG) antibody

Alternative names for Uracil-DNA glycosylase (UNG) antibody

UDG, DGU, UNG1, UNG15

SwissProt ID

P13051 (Human)

Gene ID

7374 (UNG)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Por (Porcine), Mky (Monkey), Rb (Rabbit)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F)

Background of Uracil-DNA glycosylase (UNG) antibody

The human UNG gene encodes both nuclear (UNG2) and mitochondrial (UNG1) forms of uracil-D glycosylase. These forms are generated by altertive splicing and the use of two differentially regulated promoters, PA and PB (Slupphaug et al., 1993; Nilsen et al., 1997) The cDs for UNG1 and UNG2 are of similar size (2061 and 2058 bp, respectively) and as a result the corresponding mRs are not resolved as two species in gel electrophoresis (Huag et al., 1998). Nuclear UNG2 differs from mitochondrial UNG1 in 44 amino acids of the N-termil sequence that is not necessary for catalytic activity. A major role of the UNG gene products is to repair mutagenic U:G mispairs caused by cytosine deamition. For example, UNG2 removes misincorporated dUMP residues. The level and expression pattern of UNG1 and UNG2 differs between cell and tissue type (Huag et al. 1998). Additiolly, the expression of UNG is cell cycle regulated (gelhus et al. 1995). The expression and activity of UNG has been found in general to be higher in proliferating as compared to nonproliferating tissues and cells (reviewed in Kruman et al. 2004). UNG1 is a 304 amino acid protein. UNG2 is a 313 amino acid protein.

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Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Uracil-DNA glycosylase (UNG) (transcript variant 2)

  Recombinant protein of human uracil-DNA glycosylase (UNG), transcript variant 2  
Uracil-DNA glycosylase (UNG) Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €438.00
  OriGene Technologies, Inc.

Uracil-DNA glycosylase (UNG) (full length, N-term HIS tag)

  Recombinant protein of human uracil-DNA glycosylase (UNG), nuclear gene encoding mitochondrial protein, full length, with N-terminal HIS tag, expressed in E.Coli, 50ug  
Uracil-DNA glycosylase (UNG) Human > 80 %
Preparation: .
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
E. coli
50 µg / €199.00
  OriGene Technologies, Inc.

2 Item(s)

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