Uroplakin-1b (UPK1B) antibody

Principal name

Uroplakin-1b (UPK1B) antibody

Alternative names for Uroplakin-1b (UPK1B) antibody

UP1b, Uroplakin Ib, UPIb, Tetraspanin-20, TSPAN20, Tspan-20

SwissProt ID

O75841 (Human), P38573 (Bovin), Q566D0 (Rat), Q9Z2C6 (Mouse)

Gene ID

7348 (UPK1B)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Flow Cytometry (F)

Background of Uroplakin-1b (UPK1B) antibody

The asymmetric unit membrane (AUM) forms numerous plaques, which cover the apical surface of the urothelium. These plaques are thought to strengthen the urothelium and reduce the risk of rupturing during ladder distention. They are composed of four major integral membrane proteins called uroplakins (UP). The uroplakin family comprises UPIa, UPIb, UPII, and UPIII. Family members are conserved among several species, including human, mouse, rat, rabbit, dog, pig and sheep. UPIa and UPIb form tightly packed structures with UPII and UPIII, respectively. This pairing is required for normal urothelial plaque formation and is regulated by proteolytic processing of the uroplakin proteins. Uroplakins are expressed in normal urothelium and are used as specific markers of urothelial differentiation. They are also expressed in a majority of transitional cell carcinomas of the bladder (TCCs), which make the uroplakins a useful marker for detecting bladder cancer metastasis and for staging and monitoring chemotherapeutic response.

General readings

Yu J, Lin JH, Wu XR, et al. Uroplakins Ia and Ib, two major differentiation products of bladder epithelium, belong to a family of four transmembrane domain (4TM) proteins. J. Cell Biol. 1994; 125:171-82.
Wu XR, Kong XP, Pellicer A, et al. Uroplakins in urothelial biology, function, and disease. Kidney Int. 2009; 75:1153-65.
Sun TT, Zhao H, Provet J, et al. Formation of asymmetric unit membrane during urothelial differentiation. Mol. Biol. Rep. 1996; 23:3-11.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Uroplakin-1b (UPK1B) (Center) antibody

Western blot analysis of UPK1B in mouse bladder tissue lysate with UPK1B antibody at (A) 0.5 and (B) 1 ug/mL. Rabbit IgG Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Uroplakin-1b (UPK1B) (Center) antibody

UPK1B Antibody (Center) (AP54476PU-N) IHC analysis in formalin fixed and paraffin embedded brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the UPK1B Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated. Rabbit Ig Aff - Purified Hu F, P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Uroplakin-1b (UPK1B) (C-term) antibody

UPK1B Antibody (C-term) (AP54477PU-N) western blot analysis in NCI-H292 cell line lysates (35 µg/lane). This demonstrates the UPK1B antibody detected the UPK1B protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Uroplakin-1b (UPK1B) (Center) Control Peptide

Uroplakin-1b (UPK1B)
50 µg / €160.00
  Acris Antibodies GmbH

Uroplakin-1b (UPK1B) antibody

Detection limit for recombinant GST tagged UPK1B is approximately 0.03ng/ml as a capture antibody. Mouse IgG2a 1E1 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Uroplakin-1b (UPK1B) antibody

Uroplakin-1b (UPK1B) Mouse IgG2a 4F4 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Uroplakin-1b (UPK1B) antibody

Immunohistochemistry-Paraffin: Uroplakin Ib Antibody [NBP1-80656] Immunohistochemical staining of human urinary bladder shows strong cytoplasmic and membranous positivity in urothelial cells. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Uroplakin-1b (UPK1B) antibody

Immunohistochemistry-Paraffin: Uroplakin Ib Antibody [NBP1-80657] Immunohistochemical staining of human urinary bladder shows strong cytoplasmic and membranous positivity in urothelial cells. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Uroplakin-1b (UPK1B)

Uroplakin-1b (UPK1B) Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

Uroplakin-1b (UPK1B)

Uroplakin-1b (UPK1B) Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

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per page
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