Uroplakin-3a (UPK3A) antibody

Principal name

Uroplakin-3a (UPK3A) antibody

Alternative names for Uroplakin-3a (UPK3A) antibody

UP3a, Uroplakin III, UPIII, UPK3

SwissProt ID

O75631 (Human), P38574 (Bovin), Q9JKX8 (Mouse)

Gene ID

7380 (UPK3A), 22270 (Upk3a)

Available reactivities

Bov (Bovine), Hu (Human), Por (Porcine), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Immunoprecipitation (IP), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F)

Background of Uroplakin-3a (UPK3A) antibody

UPK3A, is an abbreviation for Uroplakin-3A, also called UP3a and UPIIIa, is a component of the asymmetric unit membrane (AUM) that is a highly specialized biomembrane made by terminally differentiated urothelial cells (1). The protein may play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells (2). UPK3A also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence through FimH bacterial protein binding leading to bladder infection(3). FimH initiates bladder pathology by binding to the UPK3A uroplakin receptor complex, but the subsequent events mediating pathogenesis have not been fully characterized. Bacteria-induced UPK3a signaling may mediate bladder responses to insult by uropathogenic E. coli or UPEC. Besides structure and function, UPK3A also may be a tumor cell marker inversely expressed with malignancy grade of bladder cancer and it has already been shown as a urinary marker for the detection of bladder cancer (4). Antibody to UPK3A is a useful tool for characterizing the anti-apoptotic, structural and functional activities of this molecule (1-4).

General readings

Shapiro, E., et al. (2000) J. Urol. 164: 1048-1051.Wu, X.R., et al. (1994) J. Biol. Chem. 269:13716-13724.

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