Uroplakin-3a (UPK3A) antibody

Principal name

Uroplakin-3a (UPK3A) antibody

Alternative names for Uroplakin-3a (UPK3A) antibody

UP3a, Uroplakin III, UPIII, UPK3

SwissProt ID

O75631 (Human), P38574 (Bovin), Q9JKX8 (Mouse)

Gene ID

7380 (UPK3A), 22270 (Upk3a)

Available reactivities

Bov (Bovine), Hu (Human), Por (Porcine), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Immunoprecipitation (IP), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F)

Background of Uroplakin-3a (UPK3A) antibody

UPK3A, is an abbreviation for Uroplakin-3A, also called UP3a and UPIIIa, is a component of the asymmetric unit membrane (AUM) that is a highly specialized biomembrane made by terminally differentiated urothelial cells (1). The protein may play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells (2). UPK3A also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence through FimH bacterial protein binding leading to bladder infection(3). FimH initiates bladder pathology by binding to the UPK3A uroplakin receptor complex, but the subsequent events mediating pathogenesis have not been fully characterized. Bacteria-induced UPK3a signaling may mediate bladder responses to insult by uropathogenic E. coli or UPEC. Besides structure and function, UPK3A also may be a tumor cell marker inversely expressed with malignancy grade of bladder cancer and it has already been shown as a urinary marker for the detection of bladder cancer (4). Antibody to UPK3A is a useful tool for characterizing the anti-apoptotic, structural and functional activities of this molecule (1-4).

General readings

Shapiro, E., et al. (2000) J. Urol. 164: 1048-1051.Wu, X.R., et al. (1994) J. Biol. Chem. 269:13716-13724.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Uroplakin-3a (UPK3A) antibody

  Mouse Monoclonal Uroplakin III Antibody  
Immunohistochemistry staining of Paraffin Bladder tissue by Uroplakin III antibody (dilution: 1:25 - 1:100; visualization of staining: Membranous, cytoplasmic) Mouse IgG1 AU-1 Purified Hu P
1 ml / €1,380.00
  OriGene Technologies, Inc.

Uroplakin-3a (UPK3A) antibody

Uroplakin-3a (UPK3A) Mouse IgG1 AU1 Purified Bov, Hu, Por, Rt P, WB
50 µg / €310.00
  Acris Antibodies GmbH

Uroplakin-3a (UPK3A) antibody

Uroplakin-3a (UPK3A) Mouse IgG1 AU1 Supernatant Bov, Hu, Por, Rt P, WB
5 ml / €310.00
  Acris Antibodies GmbH

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Uroplakin-3a (UPK3A) (19-207, His-tag)

Uroplakin-3a (UPK3A) Human Purified > 90 % by SDS - PAGE E. coli
0.25 mg / €940.00
  Acris Antibodies GmbH

Uroplakin-3a (UPK3A) (19-207, His-tag)

Uroplakin-3a (UPK3A) Human Purified > 90 % by SDS - PAGE E. coli
50 µg / €370.00
  Acris Antibodies GmbH

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