USP20 antibody

Principal name

USP20 antibody

Alternative names for USP20 antibody

Ubiquitin carboxyl-terminal hydrolase 20, KIAA1003, LSFR3A, Ubiquitin thioesterase 20, Ubiquitin-specific-processing protease 20, Deubiquitinating enzyme 20

SwissProt ID

Q9Y2K6 (Human)

Gene ID

10868 (USP20)

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Ms (Mouse), Por (Porcine), Rt (Rat), Bt (Bat), Eq (Equine), Hst (Hamster), Mky (Monkey), Rb (Rabbit), Gorilla, GP (Guinea Pig)

Available hosts

Mouse, Goat, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Paraffin Sections (P)

Background of USP20 antibody

USP20 is a deubiquititing enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling.USP20 acts as a regulator of G-protein coupled receptor (GPCR) sigling by mediating the deubiquitition beta-2 adrenergic receptor (ADRB2). USP20 plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitition of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitition and disengagement from ADRB2. This suggests the existence of a dymic exchange between the ADRB2 and beta-arrestins. Deubiquitites DIO2, thereby regulating thyroid hormone regulation. USP20 deubiquitites HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity.USP20 mediates deubiquitition of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

General readings

Curcio-Morelli C, Zavacki AM, Christofollete M, Gereben B, de Freitas BC, Harney JW, Li Z, Wu G, Bianco AC.
Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation.
J Clin Invest. 2003 Jul;112(2):189-96.
PMID: 12865408

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

USP20 (C-term) antibody

TA305665 (3ug/ml) staining of paraffin embedded Human Lymph Node. Microwaved antigen retrieval with Tris/EDTA buffer pH9, HRP-staining. Goat Aff - Purified Bov, Can, Hu, Ms, Por, Rt P
0.1 mg / €325.00
  OriGene Technologies, Inc.

USP20 antibody

Anti-USP20 antibody IHC of human adrenal medulla. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit IgG Purified Bov, Bt, Can, Eq, Gorilla, Hst, Hu, Mky, Ms, Por, Rb, Rt
50 µg / €345.00
  OriGene Technologies, Inc.

USP20 antibody

Anti-USP20 antibody IHC of human adrenal medulla. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu P
50 µg / €345.00
  OriGene Technologies, Inc.

USP20 antibody

Anti-USP20 antibody IHC of human adrenal medulla. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu P
50 µg / €345.00
  OriGene Technologies, Inc.

USP20 antibody

WB Suggested Anti-USP20 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: Human heart Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

USP20 antibody

USP20 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

USP20 antibody

Western Blot analysis of USP20 expression in transfected 293T cell line (H00010868-T01) by USP20 MaxPab polyclonal antibody.

Lane 1: USP20 transfected lysate(100.43 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

USP20 antibody

USP20 Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

USP20 antibody

Immunoprecipitation of USP20 transfected lysate using anti-USP20 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with USP20 MaxPab mouse polyclonal antibody (B01) (H00010868-B01). Rabbit Serum Hu E(detection), IP
0.1 ml / €380.00
  Abnova Taiwan Corp.

USP20 antibody

USP20 Mouse IgG1 1A6 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

USP20 antibody

USP20 Goat Hu E
0.1 mg / €400.00
  Abnova Taiwan Corp.

USP20 antibody

USP20 Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

USP20 (transcript variant 1)

USP20 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

USP20

USP20 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

USP20

USP20 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

USP20

USP20 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

USP20

USP20 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Antibody Pairs

Catalog No.    

USP20 (Human) IP-WB Antibody Pair

USP20 (Human) IP-WB Antibody Pair  
1 set / €710.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

USP20 293T Cell Transient Overexpression Lysate(Denatured)

USP20 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

USP20 overexpression lysate

USP20 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

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