USP20 antibody

Principal name

USP20 antibody

Alternative names for USP20 antibody

Ubiquitin carboxyl-terminal hydrolase 20, KIAA1003, LSFR3A, Ubiquitin thioesterase 20, Ubiquitin-specific-processing protease 20, Deubiquitinating enzyme 20

SwissProt ID

Q9Y2K6 (Human)

Gene ID

10868 (USP20)

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Ms (Mouse), Por (Porcine), Rt (Rat), Bt (Bat), Eq (Equine), Hst (Hamster), Mky (Monkey), Rb (Rabbit), Gorilla, GP (Guinea Pig)

Available hosts

Mouse, Goat, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Paraffin Sections (P)

Background of USP20 antibody

USP20 is a deubiquititing enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling.USP20 acts as a regulator of G-protein coupled receptor (GPCR) sigling by mediating the deubiquitition beta-2 adrenergic receptor (ADRB2). USP20 plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitition of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitition and disengagement from ADRB2. This suggests the existence of a dymic exchange between the ADRB2 and beta-arrestins. Deubiquitites DIO2, thereby regulating thyroid hormone regulation. USP20 deubiquitites HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity.USP20 mediates deubiquitition of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

General readings

Curcio-Morelli C, Zavacki AM, Christofollete M, Gereben B, de Freitas BC, Harney JW, Li Z, Wu G, Bianco AC.
Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation.
J Clin Invest. 2003 Jul;112(2):189-96.
PMID: 12865408

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

USP20 (C-term) antibody

  Goat Anti-USP20 / VDU2 Antibody  
TA305665 (3ug/ml) staining of paraffin embedded Human Lymph Node. Microwaved antigen retrieval with Tris/EDTA buffer pH9, HRP-staining. Goat Aff - Purified Bov, Can, Hu, Ms, Por, Rt P
0.1 mg / €325.00
  OriGene Technologies, Inc.

USP20 antibody

  USP20 Rabbit Polyclonal (Internal) Antibody  
Anti-USP20 antibody IHC of human adrenal medulla. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit IgG Purified Bov, Bt, Can, Eq, Gorilla, Hst, Hu, Mky, Ms, Por, Rb, Rt
50 µg / €400.00
  OriGene Technologies, Inc.

USP20 antibody

  USP20 Rabbit Polyclonal (Internal) Antibody  
Anti-USP20 antibody IHC of human adrenal medulla. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu P
50 µg / €400.00
  OriGene Technologies, Inc.

USP20 antibody

  USP20 Rabbit Polyclonal (Internal) Antibody  
Anti-USP20 antibody IHC of human adrenal medulla. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu P
50 µg / €400.00
  OriGene Technologies, Inc.

USP20 antibody

  Rabbit Polyclonal Anti-USP20 Antibody  
WB Suggested Anti-USP20 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: Human heart Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

USP20 (transcript variant 1)

  Recombinant protein of human ubiquitin specific peptidase 20 (USP20), transcript variant 1  
USP20 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

Lysates

Catalog No.    

USP20 overexpression lysate

USP20 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

USP20 overexpression lysate

USP20 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, USP20 (mGFP-tagged) - Human ubiquitin specific peptidase 20 (USP20), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, USP20 (mGFP-tagged) - Human ubiquitin specific peptidase 20 (USP20), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, USP20 (mGFP-tagged)-Human ubiquitin specific peptidase 20 (USP20), transcript variant 3, 200 uL, >10^7 TU/mL

Lenti ORF particles, USP20 (mGFP-tagged)-Human ubiquitin specific peptidase 20 (USP20), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, USP20 (Myc-DDK tagged) - Human ubiquitin specific peptidase 20 (USP20), transcript variant 1 , 200 uL, >10^7 TU/mL

Lenti ORF particles, USP20 (Myc-DDK tagged) - Human ubiquitin specific peptidase 20 (USP20), transcript variant 1 , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Lenti ORF particles, USP20 (Myc-DDK tagged) - Human ubiquitin specific peptidase 20 (USP20), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, USP20 (Myc-DDK tagged) - Human ubiquitin specific peptidase 20 (USP20), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Lenti ORF particles, USP20 (Myc-DDK-tagged)-Human ubiquitin specific peptidase 20 (USP20), transcript variant 3, 200 uL, >10^7 TU/mL

Lenti ORF particles, USP20 (Myc-DDK-tagged)-Human ubiquitin specific peptidase 20 (USP20), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

13 Item(s)

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