USP33 / VDU1 antibody

Principal name

USP33 / VDU1 antibody

Alternative names for USP33 / VDU1 antibody

Ubiquitin carboxyl-terminal hydrolase 33, KIAA1097, Ubiquitin thioesterase 33, VHL-interacting deubiquitinating enzyme 1

SwissProt ID

Q8TEY7 (Human)

Gene ID

23032 (USP33)

Available reactivities

Hu (Human), Ms (Mouse)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), EPair for Elisa (EPair), Immunoprecipitation (IP)

Background of USP33 / VDU1 antibody

Type 2 iodothyronine deiodinase (D2) is an integral membrane selenoenzyme that stimulates the pro-hormone thyroxine (T4) and supplies the majority of the 3,5,3'-triiodothyronine (T3) essential for brain development.1 T4 catalysis accelerates selective conjugation to ubiquitin and thereby renders D2 inactive, a posttranslational feedback mechanism used to maintain acceptable T3 levels.2,3 Ub-D2 was the first recognized substrate for von Hippel?Lindau protein?interacting (pVHL-interacting) deubiquitinating enzyme-1 (VDU1).4 VDU proteins colocalize with D2 in the endoplasmic reticulum, and their coexpression provides D2 resistance to degradation. VDU1 expression is substantially upregulated in brown adipocytes by norepinephrine or cold exposure, further amplifying D2 activity. VDU1 and VDU2 are coexpressed with D2 in many human tissues, including brain, heart, and skeletal muscle, suggesting potential roles in neurological development, cardiac function, and energy management, in addition to thermal homeostasis.VDU1- or VDU2-catalyzed deubiquitination recycles inactive Ub-D2 to its active deubiquitinated form, circumventing the proteasomal degradation pathway. Thus, Ub-D2 can be either reactivated or degraded, with the balance between these two processes influenced by VDU activity.VDU1-catalyzed D2 deubiquitination may be an important participant in the adaptive mechanism that regulates thyroid hormone action. The reversible ubiquitination-dependent mechanism regulating D2 activity permits highly responsive control of thyroid hormone activation.5,6

  1. Quick-Filters:
  2. Highly Validated (1)

11 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

USP33 / VDU1 antibody

Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG1 5B5 Purified Hu E, ICC/IF, IP, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

USP33 / VDU1 antibody

  USP33 Rabbit Polyclonal (Internal) Antibody  
Anti-USP33 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu P
50 µg / €400.00
  OriGene Technologies, Inc.

USP33 / VDU1 antibody

  USP33 Rabbit Polyclonal (Internal) Antibody  
Anti-USP33 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu P
50 µg / €400.00
  OriGene Technologies, Inc.

USP33 / VDU1 (C-term) antibody

Western blot analysis of anti-VDU1 (C-term) Pab (Cat.#AP12074PU-N) in T47D cell line lysate (35ug/lane). VDU1 (arrow) was detected using the purified Pab. Rabbit Ig Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

USP33 / VDU1 (transcript variant 2)

  Recombinant protein of human ubiquitin specific peptidase 33 (USP33), transcript variant 2  
USP33 / VDU1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

USP33 overexpression lysate

USP33 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

USP33 overexpression lysate

USP33 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, USP33 (mGFP-tagged) - Human ubiquitin specific peptidase 33 (USP33), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, USP33 (mGFP-tagged) - Human ubiquitin specific peptidase 33 (USP33), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,900.00
  OriGene Technologies, Inc.

Lenti ORF particles, USP33 (mGFP-tagged)-Human ubiquitin specific peptidase 33 (USP33), transcript variant 3, 200 uL, >10^7 TU/mL

Lenti ORF particles, USP33 (mGFP-tagged)-Human ubiquitin specific peptidase 33 (USP33), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, USP33 (Myc-DDK tagged) - Human ubiquitin specific peptidase 33 (USP33), transcript variant 2 , 200 uL, >10^7 TU/mL

Lenti ORF particles, USP33 (Myc-DDK tagged) - Human ubiquitin specific peptidase 33 (USP33), transcript variant 2 , 200 uL, >10^7 TU/mL  
200 µl / €1,710.00
  OriGene Technologies, Inc.

Lenti ORF particles, USP33 (Myc-DDK-tagged)-Human ubiquitin specific peptidase 33 (USP33), transcript variant 3, 200 uL, >10^7 TU/mL

Lenti ORF particles, USP33 (Myc-DDK-tagged)-Human ubiquitin specific peptidase 33 (USP33), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

11 Item(s)

per page
  • LinkedIn