USP33 / VDU1 antibody

Principal name

USP33 / VDU1 antibody

Alternative names for USP33 / VDU1 antibody

Ubiquitin carboxyl-terminal hydrolase 33, KIAA1097, Ubiquitin thioesterase 33, VHL-interacting deubiquitinating enzyme 1

SwissProt ID

Q8TEY7 (Human)

Gene ID

23032 (USP33), 1123032 (lrgB)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Mky (Monkey), Bov (Bovine), Can (Canine), Eq (Equine), Rb (Rabbit), Gorilla

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunoprecipitation (IP), ELISA (detection) (E(detection)), EPair for Elisa (EPair)

Background of USP33 / VDU1 antibody

Type 2 iodothyronine deiodinase (D2) is an integral membrane selenoenzyme that stimulates the pro-hormone thyroxine (T4) and supplies the majority of the 3,5,3'-triiodothyronine (T3) essential for brain development.1 T4 catalysis accelerates selective conjugation to ubiquitin and thereby renders D2 inactive, a posttranslational feedback mechanism used to maintain acceptable T3 levels.2,3 Ub-D2 was the first recognized substrate for von Hippel?Lindau protein?interacting (pVHL-interacting) deubiquitinating enzyme-1 (VDU1).4 VDU proteins colocalize with D2 in the endoplasmic reticulum, and their coexpression provides D2 resistance to degradation. VDU1 expression is substantially upregulated in brown adipocytes by norepinephrine or cold exposure, further amplifying D2 activity. VDU1 and VDU2 are coexpressed with D2 in many human tissues, including brain, heart, and skeletal muscle, suggesting potential roles in neurological development, cardiac function, and energy management, in addition to thermal homeostasis.VDU1- or VDU2-catalyzed deubiquitination recycles inactive Ub-D2 to its active deubiquitinated form, circumventing the proteasomal degradation pathway. Thus, Ub-D2 can be either reactivated or degraded, with the balance between these two processes influenced by VDU activity.VDU1-catalyzed D2 deubiquitination may be an important participant in the adaptive mechanism that regulates thyroid hormone action. The reversible ubiquitination-dependent mechanism regulating D2 activity permits highly responsive control of thyroid hormone activation.5,6

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

USP33 / VDU1 antibody

Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG1 5B5 Purified Hu E, ICC/IF, IP, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

USP33 / VDU1 antibody

Anti-USP33 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu P
50 µg / €345.00
  OriGene Technologies, Inc.

USP33 / VDU1 antibody

Anti-USP33 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu P
50 µg / €345.00
  OriGene Technologies, Inc.

USP33 / VDU1 (C-term) antibody

Western blot analysis of anti-VDU1 (C-term) Pab (Cat.#AP12074PU-N) in T47D cell line lysate (35ug/lane). VDU1 (arrow) was detected using the purified Pab. Rabbit Ig Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

USP33 / VDU1 antibody

USP33 / VDU1 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

USP33 / VDU1 antibody

Western Blot analysis of USP33 expression in transfected 293T cell line (H00023032-T01) by USP33 MaxPab polyclonal antibody.

Lane 1: USP33 transfected lysate(100.21 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

USP33 / VDU1 antibody

USP33 MaxPab rabbit polyclonal antibody. Western Blot analysis of USP33 expression in mouse kidney. Rabbit Purified Hu, Ms E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

USP33 / VDU1 antibody

Immunoperoxidase of monoclonal antibody to USP33 on formalin-fixed paraffin-embedded human tonsil. [antibody concentration 3ug/ml] Mouse IgG1 5B5 Purified Hu E, ICC/IF, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

USP33 / VDU1 antibody

Western blot analysis of USP33 polyclonal antibody ( Cat # PAB4230 ) in T-47D cell line lysate ( 35 µg/lane ) . USP33 ( arrow ) was detected using the purified USP33 polyclonal antibody ( Cat # PAB4230 ) . Rabbit Hu E, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

USP33 / VDU1 antibody

Immunohistochemistry-Paraffin: USP33 Antibody [NB110-40693] - See Notes, IHC Caption B Rabbit Aff - Purified Hu IP, P, WB
0.1 mg / €440.00
  Novus Biologicals Inc.

USP33 / VDU1 antibody

Immunohistochemistry-Paraffin: USP33 Antibody [NBP1-82931] - Immunohistochemical staining of human kidney shows moderate cytoplasmic positivity in tubular cells. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

USP33 / VDU1 (transcript variant 2)

USP33 / VDU1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

USP33 / VDU1

USP33 / VDU1 Human Purified
2 µg / €300.00
  Abnova Taiwan Corp.

USP33 / VDU1

USP33 / VDU1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

USP33 / VDU1

USP33 / VDU1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Antibody Pairs

Catalog No.    

USP33 (Human) IP-WB Antibody Pair

USP33 (Human) IP-WB Antibody Pair  
1 set / €710.00
  Abnova Taiwan Corp.

USP33 (Human) Matched Antibody Pair

USP33 (Human) Matched Antibody Pair  
1 set / €710.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

USP33 293T Cell Transient Overexpression Lysate(Denatured)

USP33 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

USP33 overexpression lysate

USP33 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

USP33 overexpression lysate

USP33 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

20 Item(s)

per page
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