USP6 / TRE2 antibody

Principal name

USP6 / TRE2 antibody

Alternative names for USP6 / TRE2 antibody

Ubiquitin carboxyl-terminal hydrolase 6, TRE-2, HRP1, Ubiquitin thioesterase 6, Ubiquitin-specific-processing protease 6, Deubiquitinating enzyme 6

SwissProt ID

P35125 (Human)

Gene ID

9098 (USP6)

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Ms (Mouse), Por (Porcine), Rb (Rabbit), Rt (Rat)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB)

Background of USP6 / TRE2 antibody

Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Catalyzes its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity. Promotes plasma membrane localization of ARF6 and selectively regulates ARF6-dependent endocytic protein trafficking. Is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation.
A chromosomal aberration involving USP6 is a common genetic feature of aneurysmal bone cyst, a benign osseous neoplasm. Translocation t(16;17)(q22;p13) with CDH11. The translocation generates a fusion gene in which the strong CDH11 promoter is fused to the entire USP6 coding sequence, resulting in USP6 transcriptional up-regulation.

General readings

1. Urso ML, Scrimgeour AG, Chen YW, Thompson PD, Clarkson PM. Analysis of human skeletal muscle after 48 h immobilization reveals alterations in mRNA and protein for extracellular matrix components. J Appl Physiol. 2006 Oct;101(4):1136-48.
PMID: 16763108

4 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

USP6 / TRE2 antibody

  Goat Anti-USP6 / TRE2 / TRE17 Antibody  
(2ug/ml) staining of Human Placenta lysate (35ug protein in RIPA buffer) with (B) and without (A) blocking with the immunizing peptide. Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

USP6 / TRE2 antibody

  Rabbit Polyclonal Anti-USP6 Antibody  
Host: Rabbit; Target Name: USP6; Sample Tissue: Jurkat Whole Cell lysates; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, USP6 (mGFP-tagged) - Human ubiquitin specific peptidase 6 (Tre-2 oncogene) (USP6), 200 uL, >10^7 TU/mL

Lenti ORF particles, USP6 (mGFP-tagged) - Human ubiquitin specific peptidase 6 (Tre-2 oncogene) (USP6), 200 uL, >10^7 TU/mL  
200 µl / €2,530.00
  OriGene Technologies, Inc.

Lenti ORF particles, USP6 (Myc-DDK tagged) - Human ubiquitin specific peptidase 6 (Tre-2 oncogene) (USP6) , 200 uL, >10^7 TU/mL

Lenti ORF particles, USP6 (Myc-DDK tagged) - Human ubiquitin specific peptidase 6 (Tre-2 oncogene) (USP6) , 200 uL, >10^7 TU/mL  
200 µl / €2,280.00
  OriGene Technologies, Inc.

4 Item(s)

per page
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