USP7 / HAUSP antibody

Principal name

USP7 / HAUSP antibody

Alternative names for USP7 / HAUSP antibody

Ubiquitin carboxyl-terminal hydrolase 7, Ubiquitin thioesterase 7, Ubiquitin-specific-processing protease 7, Deubiquitinating enzyme 7, Herpesvirus-associated ubiquitin-specific protease

SwissProt ID

Q4VSI4 (Rat), Q6A4J8 (Mouse), Q6U7I1 (Chick), Q93009 (Human)

Gene ID

7874 (USP7)

Available reactivities

Hu (Human), Ms (Mouse), Bov (Bovine), Can (Canine), Chk (Chicken), Mky (Monkey), Rt (Rat), Ze (Zebrafish), Chimp (Chimpanzee)

Available hosts

Rabbit, Mouse

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Immunoprecipitation (IP), PLA/Proximity ligation assay (PLA), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Flow Cytometry (F)

Background of USP7 / HAUSP antibody

Hydrolase that deubiquitites target proteins such as FOXO4,p53/TP53,MDM2,ERCC6,DNMT1,UHRF1,PTEN and DAXX.Together with DAXX,prevents MDM2 self-ubiquitition and enhances the E3 ligase activity of MDM2 towards p53/TP53,thereby promoting p53/TP53 ubiquitition and proteasomal degradation.Deubiquitites p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2,and also induces p53/TP53-dependent cell growth repression and apoptosis.Deubiquitition of FOXO4 in presence of hydrogen peroxide is not dependent on p53/TP53 and inhibits FOXO4-induced transcriptiol activity.In association with DAXX,is involved in the deubiquitition and translocation of PTEN from the nucleus to the cytoplasm,both processes that are counteracted by PML.Involved in cell proliferation during early embryonic development.Involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage:recruited to D damage sites following interaction with KIAA1530/UVSSA and promotes deubiquitition of ERCC6,preventing UV-induced degradation of ERCC6.Contributes to the overall stabilization and trans-activation capability of the herpesvirus 1 trans-acting transcriptiol protein ICP0/VMW110 during HSV-1 infection.Involved in maintence of D methylation via its interaction with UHRF1 and DNMT1:acts by mediating deubiquitition of UHRF1 and DNMT1,preventing their degradation and promoting D methylation by DNMT1.Exhibits a preference towards 'Lys-48'-linked Ubiquitin chains.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

USP7 / HAUSP antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-USP7 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA503987) Mouse IgG1 OTI1F12 Purified Hu F, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

USP7 / HAUSP antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-USP7 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA503988) Mouse IgG1 OTI1B2 Purified Hu F, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

USP7 / HAUSP antibody

Immunohistochemical staining of paraffin-embedded Human endometrium tissue within the normal limits using anti-USP7 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA504060) Mouse IgG1 OTI3D3 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

USP7 / HAUSP antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human thyroid tissue using anti-USP7 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA504061) Mouse IgG1 OTI3D5 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

USP7 / HAUSP antibody

Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-USP7 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA504062) Mouse IgG1 OTI3C1 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

USP7 / HAUSP antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-USP7 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA504063) Mouse IgG1 OTI3F7 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

USP7 / HAUSP antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-USP7 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA504064) Mouse IgG1 OTI3C7 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

USP7 / HAUSP antibody

Immunohistochemistry-Paraffin: USP7 Antibody [NB100-513] - FFPE section of mouse squamous cell carcinoma.  Affinity purified rabbit anti-USP7 used at a dilution of 1:100. Detection: DAB Rabbit Aff - Purified Hu, Ms ICC/IF, IP, P, PLA, WB
0.1 mg / €440.00
  Novus Biologicals Inc.

USP7 / HAUSP antibody

Western blot using affinity purified anti-HAUSP antibody shows detection of HAUSP in various cell lysates at 130 kDa (lane 1 - HeLa nuclear extract, lane 2 - HeLa, Lane 3 - A431, Lane 4 - MCF7, Lane 5 - 3T3).  The antibody is blocked by pre-incubation with the immunizing peptide (lanes 6 - 10) using the same lysates.  A 1:500 dilution of the primary antibody was used for detection followed by a 1:5,000 dilution of HRP Gt-a-Rabbit IgG.  Exposure time was 30 s. Rabbit IgG Aff - Purified Bov, Can, Chimp, Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

USP7 / HAUSP antibody

Western blot analysis of extracts of various cell lines, using USP7 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

USP7 / HAUSP antibody

Western blot detection of HAUSP / USP7 in Hela and K562 cell lysates using HAUSP / USP7 mouse mAb (1:200 diluted),with super ECL.Predicted band size:135KDa.Observed band size:135KDa. Mouse IgG1 3E4-D10-E8 Purified WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

USP7 / HAUSP antibody

Western blot analysis using HAUSP antibody Cat.-No AM06486SU-N against MCF-7 (1) cell lysate. Mouse IgG1 5F11 Ascites Hu E, WB
0.1 ml / €400.00
  Acris Antibodies GmbH

USP7 / HAUSP (30-41) antibody

Figure 1. Formalin-Fixed Paraffin-Embedded (FFPE) on Skeletal Muscle. Rabbit Aff - Purified Bov, Can, Chk, Hu, Mky, Ms, Rt, Ze E, ICC/IF, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

USP7 / HAUSP Control Peptide

USP7 / HAUSP Purified
50 µg / €190.00
  Acris Antibodies GmbH

USP7 / HAUSP (C-term) antibody

(LEFT) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. (RIGHT) Formalin-fixed and paraffin-embedded human testis tissue reacted with USP7 antibody (C-term) (Cat.#AP12016PU-N), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

USP7 / HAUSP (Center) antibody

USP7 Antibody (Center) (AP54492PU-N) western blot analysis in A2058 cell line lysates (35 µg/lane). This demonstrates the USP7 antibody detected the USP7 protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

USP7 / HAUSP antibody

USP7 / HAUSP Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

USP7 / HAUSP antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the USP7 polyclonal antibody ( Cat # PAB4186 ) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining . This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated . HC = hepatocarcinoma . Rabbit Hu E, P, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

USP7 / HAUSP antibody

USP7 / HAUSP Rabbit Chk, Hu, Ms IP, WB
0.1 ml / €400.00
  Abnova Taiwan Corp.

USP7 / HAUSP antibody

Western blot using USP7 polyclonal antibody ( Cat # PAB10225 ) shows detection of USP7 in various cell lysates at 130 kDa ( lane 1 - HeLa nuclear extract, lane 2 - HeLa, Lane 3 - A-431, Lane 4 - MCF-7, Lane 5 - 3T3 ).
The antibody is blocked by pre-incubation with the immunizing peptide ( lanes 6 - 10 ) using the same lysates.
A 1:500 dilution of the primary antibody was used for detection followed by a 1:5,000 dilution of HRP Gt-a-Rabbit IgG.
Exposure time was 30 sec. Bov, Chimp, Chk, Hu, Ms, Rt
0.1 mg / €560.00
  Abnova Taiwan Corp.

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