Vasopressin V1b receptor (V1bR) antibody

Principal name

Vasopressin V1b receptor (V1bR) antibody

Alternative names for Vasopressin V1b receptor (V1bR) antibody

AVPR V1b, AVPR V3, Avpr1b, Vasopressin V3 receptor, Antidiuretic hormone receptor 1b

SwissProt ID

P47901 (Human), P48974 (Rat), Q9WU02 (Mouse)

Gene ID

553 (AVPR1B), 26361 (Avpr1b), 29462

Available reactivities

Hu (Human), Rt (Rat), Can (Canine), Bt (Bat), Bov (Bovine), Eq (Equine), Mky (Monkey), Ms (Mouse), Op (Opossum), Por (Porcine), Prim (Primate), Rb (Rabbit), Bear

Available hosts

Goat, Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of Vasopressin V1b receptor (V1bR) antibody

Vasopressin (AVP), the antidiuretic hormone, is a cyclic nonpeptide that is involved in the regulation of body fluid osmolality. AVP mediates its effects through a family of G protein coupled receptors, the vasopressin receptors type V1a, V2 and V3 (also designated V1b). The AVP receptor V1a is responsible for several functions, including blood vessel constriction, liver glycogenolysis and platelet adhesion. It is detected as an 85-90 kDa full length protein and a 46 kDa protein, which results from proteolytic cleavage of its amino terminus. The V1a receptor is coupled to Gq/11 protein, which increases the intracellular calcium concentration. The human AVP receptor V2 gene maps to chromosome Xq28 and is expressed in lung and kidney. Mutations in the V2 receptor result in nephrogenic diabetes insipidus (NDI), a rare X-linked disorder characterized by the inability of the kidney to concentrate urine in response to AVP. The AVP Receptor V2 activates the Gs protein and the cyclic AMP second messenger system. The AVP receptor V3 is preferentially expressed in the pituitary and stimulates the release of adrenocorticotropic hormone (ACTH) in response to AVP by mobilizing intracellular calcium stores. AVP receptor antagonists may have potential therapeutic effects in hypertension, congestive heart failure, nephrotic syndrome and ACTH-secreting tumors.

General readings

Dempster EL, Burcescu I, Wigg K, Kiss E, Baji I, Gadoros J, Tamás Z, Kennedy JL, Vetró A, Kovacs M, Barr CL.
Evidence of an association between the vasopressin V1b receptor gene (AVPR1B) and childhood-onset mood disorders.
Arch Gen Psychiatry. 2007 Oct;64(10):1189-95
PMID: 17909131

2 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Vasopressin V1b receptor (V1bR) (N-term extracell. dom.) antibody

  AVPR1B Rabbit Polyclonal (N-Terminus) Antibody  
Vasopressin V1b receptor (V1bR) Rabbit Aff - Purified Bear, Bov, Bt, Can, Elephant, Eq, Hu, Mky, Ms, Op, Por, Prim, Rb, Rt P
50 µg / €425.00
  OriGene Technologies, Inc.

Vasopressin V1b receptor (V1bR) (3rd Cytopl. Dom.) antibody

  AVPR1B Rabbit Polyclonal (Cytoplasmic Domain) Antibody  
Vasopressin V1b receptor (V1bR) Rabbit Aff - Purified Bt, Elephant, Hu, Mky, Por, Prim P
50 µg / €425.00
  OriGene Technologies, Inc.

2 Item(s)

per page
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