VAV3 antibody

Principal name

VAV3 antibody

Alternative names for VAV3 antibody

VAV-3, Guanine nucleotide exchange factor VAV3

SwissProt ID

Q9R0C8 (Mouse), Q9UKW4 (Human)

Gene ID

10451 (VAV3)

Available reactivities

Hu (Human), Ms (Mouse), Can (Canine), Rt (Rat)

Available hosts

Rabbit, Goat

Available applications

Western blot / Immunoblot (WB), Immunoprecipitation (IP), Flow Cytometry (F), Enzyme Immunoassay (E), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C)

Background of VAV3 antibody

Vav proteins belong to the guanidine nucleotide exchange factor family of proteins that couple receptors to Rho-GTPases. The VAV family has currently three members in mammalian cells (VAV 1, VAV 2, and VAV 3). VAV 1 contains multiple protein binding motifs, indicating a role for VAV 1 as an adaptor protein linking cell surface receptors to downstream signaling proteins. VAV 1 is exclusively expressed in hematopoietic cells and plays a significant role in lymphocyte development and antigen receptor mediated activation of NFAT and NF(kappa)B, and in more delayed responses such as the production of cytokines, including IL-2, IL-3, IFN lambda, and TNF alpha. VAV 3 is also involved in activating JNK, p21-activated kinase (PAK) and PLC lambda, implicating a critical role in cytoskeletal rearrangement. VAV 3 is inducibly tyrosine phosphorylated in response to stimulation of the epidermal growth factor (EGFR), platelet-derived growth factor (PDGFR) and T-cell receptors (TCR), enhancing its guanine nucleotide exchange factor activity in vitro. Tyrosine 173 is the regulatory phosphorylation site of VAV 3.

General readings

Movilla N & Bustelo XR Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins. Mol Cell Biol 19:7870-85 (1999). PubMed: 10523675
Search PubMed (MEDLINE) for references to VAV3

14 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

VAV3 antibody

TA302958 (0.3µg/ml) staining of human bone marrow lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Purified Can, Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

VAV3 antibody

ELISA: VAV3 Antibody Rabbit IgG Purified Hu E
0.1 mg / €325.00
  OriGene Technologies, Inc.

VAV3 (567-578) antibody

Human Skin (formalin-fixed, paraffin-embedded) stained with VAV3 antibody AP22535PU-N at 5 µg/ml followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Goat Aff - Purified Can, Elephant, Hu, Mky, Op, Por, Prim, Rb E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

VAV3 pTyr173 antibody

Western blot analysis of extracts from JK cells using VAV3 (Phospho-Tyr173) Antibody AP55844PU-N.The lane on the right is treated with the antigen-specific peptide. Rabbit Aff - Purified Hu, Ms WB
0.1 ml / €340.00
  Acris Antibodies GmbH

VAV3 pTyr173 antibody

Western blot analysis of extracts from JK cells using VAV3 (Phospho-Tyr173) Antibody AP55844PU-N.The lane on the right is treated with the antigen-specific peptide. Rabbit Aff - Purified Hu, Ms WB
50 µl / €270.00
  Acris Antibodies GmbH

VAV3 antibody

VAV3 polyclonal antibody ( Cat # PAB6675 ) ( 0.3 µg/ml ) staining of human bone marrow lysate ( 35 µg protein in RIPA buffer ) . Primary incubation was 1 hour. Detected by chemiluminescence. Goat Hu E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

VAV3 antibody

ELISA: VAV3 Antibody [27210002] Rabbit Hu E, P, WB
50 µg / €440.00
  Novus Biologicals Inc.

VAV3 antibody

Western Blot: VAV3 Antibody (EP1130Y) [NB110-57641] - Western blot analysis on Jurket cell lysate using anti-Vav3 (cat. # 110-57641), dilution 1:100,000 Rabbit IgG EP1130Y Hu, Ms F, IP, WB
0.1 ml / €480.00
  Novus Biologicals Inc.

VAV3 antibody

NB300-817 (0.3ug/ml) staining of Human Bone Marrow lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat IgG Aff - Purified Hu E, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

VAV3 antibody

Immunohistochemistry-Paraffin: VAV3 Antibody [NBP1-86382] Immunohistochemical staining of human pancreas shows cytoplasmic and nuclear positivity in exocrine cells. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

VAV3 (transcript variant 2)

VAV3 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

VAV3 (transcript variant 1)

VAV3 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

VAV3 overexpression lysate

VAV3 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

VAV3 overexpression lysate

VAV3 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

14 Item(s)

per page
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