VEGF-B antibody

Principal name

VEGF-B antibody

Alternative names for VEGF-B antibody

VEGFB, VRF, Vascular endothelial growth factor B, VEGF-related factor

SwissProt ID

O35485 (Rat), P49765 (Human), P49766 (Mouse), Q9XS49 (Bovin)

Gene ID

7423 (VEGFB), 22340 (Vegfb)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Rb (Rabbit), Mky (Monkey)

Available hosts

Rabbit, Goat, Mouse, Rat

Available applications

Enzyme Immunoassay (E), Paraffin Sections (P), Western blot / Immunoblot (WB), EPair for Elisa (EPair), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of VEGF-B antibody

Vascular endothelial growth factor B (VEGF-B), also known as vascular endothelial growth factor-related factor (VRF), is a member of the VEGF family of growth factors that share structural and functional similarity (1, 2). Five mammalian members, including VEGF-A, B, C, D and PlGF, have been identified. VEGF family members are disulfide-linked dimeric proteins that are important regulators of physiological and pathological vasculogenesis, angiogenesis and lymphangiogenesis. VEGF-B is expressed in most tissues, especially in heart, skeletal muscle and pancreas. In many tissues, VEGF-B is coexpressed and can heterodimerize with VEGF (3). By alternative splicing, two isoforms of mature VEGF-B containing 167 or 186 amino acid (aa) residues exist (3, 4). The two VEGF-B isoforms have identical amino-terminal cysteine knot VEGF homology domains but the carboxyl end of VEGF-B167 differs from that of VEGF-B186 by the presence of a highly basic cysteine-rich heparin binding domain. Whereas VEGF-B186 is a secreted diffusible protein, VEGF-B167 is sequestered into the cell matrix after secretion. Both VEGF-B isoforms bind VEGF receptor 1 (VEGFR-1), but not VEGFR-2 or VEGFR-3 (5). On endothelial cells, ligation of VEGFR-1 by VEGF-B has been shown to regulate the expression and activity of urokinase type plasminogen activator and plasminogen activator inhibitor 1. VEGF-B167 and a proteolytically processed form of VEGF-B186 (VEGF-B127) also bind neuropilin1 (NP1), a type I transmembrane receptor for semaphorins/collapsins, ligands involved in neuron guidance (6). Besides VEGF-B, NP1 has been shown to bind PlGF-2, VEGF165 and VEGFR-1 (6, 7). The many interactions of NP1 with VEGF ligands and receptor suggest that NP1 may function as a regulator of angiogenesis (7).

General readings

Claesson-Welsh L. (2008) Arterioscler Thromb Vasc Biol. 28(9):1575-6.
Malik AK,, et al. (2006) Blood. 107(2):550-7.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

VEGF-B antibody

Western blot analysis of extracts from Jurkat cells, using VEGFB antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

VEGF-B antibody

Predicted band size: 21 kDa . Positive control: Mouse brain tissue lysate. Recommended dilution: 1/500-2000. (Gel: 10%SDS-PAGE Lysate: 40 ug Primary antibody: 1/700 dilution Secondary antibody: Donkey anti Rabbit IgG - H&L (HRP) at 1/3000 dilution Exposure time: 5 seconds) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

VEGF-B antibody

Western blot analysis of VEGFB expression in Jurkat whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

VEGF-B antibody

Western blot analysis of extracts of mouse heart cell lines, using VEGFB antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

VEGF-B antibody

Western blot analysis of VEGFB expression in Jurkat cells Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

VEGF-B antibody

Anti-VEGFB mouse monoclonal antibody (TA507194) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY VEGFB(RC202426). Mouse IgG1 OTI2D6 Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

VEGF-B antibody

Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-VEGFB mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA507196) Mouse IgG2b OTI2C4 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

VEGF-B antibody

Immunohistochemical staining of paraffin-embedded Human liver tissue within the normal limits using anti-VEGFB mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA507205) Mouse IgG1 OTI1H9 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

VEGF-B antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY VEGFB (RC202426, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-VEGFB. Rabbit IgG Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

VEGF-B antibody

Western blot (WB) analysis of VEGFB antibody (Cat.-No.: AP06477PU-N) in extracts from Jurkat cells. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

VEGF-B (VEGF-B167) antibody

VEGF-B Rabbit IgG Purified Hu WB
0.2 mg / €370.00
  Acris Antibodies GmbH

VEGF-B (VEGF-B167) antibody

VEGF-B Rabbit IgG Purified Hu WB
0.1 mg / €270.00
  Acris Antibodies GmbH

VEGF-B antibody

VEGF-B Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

VEGF-B antibody

VEGF-B Mouse Serum Hu E
50 µl / €290.00
  Abnova Taiwan Corp.

VEGF-B antibody

Western Blot analysis of VEGFB expression in transfected 293T cell line (H00007423-T01) by VEGFB MaxPab polyclonal antibody.

Lane 1: VEGFB transfected lysate(22.77 KDa).
Lane 2: Non-transfected lysate. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

VEGF-B antibody

Immunoprecipitation of VEGFB transfected lysate using anti-VEGFB MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with VEGFB MaxPab mouse polyclonal antibody (B01) (H00007423-B01). Rabbit Serum Hu E(detection), IP
0.1 ml / €380.00
  Abnova Taiwan Corp.

VEGF-B antibody

Proximity Ligation Analysis (PLA) of protein-protein interactions between VEGFB and VEGFA. HeLa cells were stained with anti-VEGFB rabbit purified polyclonal 1:1200 and anti-VEGFA mouse monoclonal antibody 1:50. Signals were detected by Duolink® 30 Detection Kit 613(red), and nuclei were counterstained with DAPI (blue). Each red dot represents the detection of protein-protein interaction complex. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

VEGF-B antibody

VEGF-B Mouse IgG2b 4H5 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

VEGF-B antibody

VEGF-B Rat Ms WB
0.1 mg / €730.00
  Abnova Taiwan Corp.

VEGF-B antibody

Western blot analysis of extracts from Jurkat cells, using VEGFB Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
50 µg / €205.00
  Assay Biotech

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