VEGFR-1 / Flt-1 antibody

Principal name

VEGFR-1 / Flt-1 antibody

Alternative names for VEGFR-1 / Flt-1 antibody

VEGFR1, FLT1, FLT, FRT, VEGF Receptor 1, Vascular endothelial growth factor receptor 1, Vascular permeability factor receptor, Tyrosine-protein kinase receptor FLT, Tyrosine-protein kinase FRT, Fms-like tyrosine kinase 1

SwissProt ID

P17948 (Human), P35969 (Mouse), P53767 (Rat), Q8QHL3 (Chick)

Gene ID

2321 (FLT1), 14254 (Flt1), 54251

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Can (Canine), Eq (Equine), Mky (Monkey), Op (Opossum), Bear, Gorilla, African clawed frog, Chk (Chicken), Por (Porcine), Sh (Sheep)

Available hosts

Rabbit, Mouse, Rat, Sheep, Chicken

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Enzyme Immunoassay (E), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), ELISA (detection) (E(detection)), Functional assay (FN)

Background of VEGFR-1 / Flt-1 antibody

VEGF Receptor 1 (vascular endothelial growth factor receptor 1 or VEGFR1; also called Flt1 in mouse) is a tyrosine-protein kise which acts as a cell-surface receptor for VEGFA, VEGFB and PGF ligands for playing an essential role in the embryonic vasculature development and regulation of angiogenesis (normal as well as cancerous tissues), cell survival, migration, macrophage function, chemotaxis, and tumor invasion. VEGFR1 is a 180-185 kD glycoprotein expressed primarily in vascular endothelial cells and also found in a wide range of non-endothelial cells, such as monocytes and macrophages, human trophoblasts, rel mesangial cells, vascular smooth muscle cells, dendritic cells and different human tumour cell types. Interestingly, VEGFR1 acts as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells, whereas it promotes endothelial cell proliferation, survival and angiogenesis in adults. VEGFR1 expression is regulated by hypoxia through HREs in VEGFR1 promoter. It exists in an ictive conformation in the absence of bound ligand and binding of VEGFA, VEGFB or PGF leads to its dimerization followed by tyrosine residue autophosphorylation mediated activation. VEGFR1 phosphorylation sites includes Tyr794, Tyr1169, Tyr1213, Tyr1242, Tyr1327, Tyr1333 etc. and VEGFR1 phosphorylation pattern depends on the ligand, e.g. PlGF, but not VEGFA, induces phosphorylation of Tyr1309. VEGFR1 has been shown to exert its diverse biological activities through its effects on multiple sigl transduction pathways including VEGF, KDR, PLCG, PI3K, MAPK etc.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

VEGFR-1/2 antibody

VEGFR-1/2 Rabbit Hu, Ms, Rt WB
25 µl / €200.00
  Novus Biologicals Inc.

VEGFR-1 / Flt-1 antibody

Standard ELISA assay with coating of 2.5 µg/ml Mouse sFlt-1-Fc using anti Human Flt-1 antibodies Mouse IgG1 FLTEWC Purified Hu, Ms E, IP, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

VEGFR-1 / Flt-1 (C-term) antibody

Figure 1. AP15557PU-N VEGFR-1/Flt-1 antibody staining of Human Placenta. Rabbit Purified Hu, Ms, Rt P
0.5 ml / €360.00
  Acris Antibodies GmbH

VEGFR-1 / Flt-1 (C-term) antibody

Figure 1. AP15557PU-N VEGFR-1/Flt-1 antibody staining of Human Placenta. Rabbit Aff - Purified Hu, Ms, Rt P
1 ml / €520.00
  Acris Antibodies GmbH

VEGFR-1 / Flt-1 (C-term) antibody

Figure 1. AP15557PU-N VEGFR-1/Flt-1 antibody staining of Human Placenta. Rabbit Purified Hu, Ms, Rt P
0.1 ml / €190.00
  Acris Antibodies GmbH

VEGFR-1 / Flt-1 antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue using VEGFR1 antibody.The picture on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

VEGFR-1 / Flt-1 antibody

Immunoblot analysis of non-boiled NP-40 lysates from Human Umbilical Vein Endothelial Cells (HUVEC) run on SDS-PAGE under non-reducing conditions. The membrane was probed with 2 ug/ml of Anti-Human VEGF Receptor 1 (Flt1) Purified followed by Anti-Rat IgG HRP. Rat 7A6 Purified Hu WB
25 µg / €120.00
  OriGene Technologies, Inc.

VEGFR-1 / Flt-1 antibody

Predicted cell location: Cytoplasm, Cell membrane. Positive control: HepG2 cell. Recommended dilution: 1/100-500.The image is immunocytochemistry of methanol-fixed HepG2 cell using FLT1 antibody at dilution 1/100, the secondary antibody is FITC conjugated Goat Anti-Rabbit IgG at dilution 1/200, blue is nucleus staining by Dapi. (Original magnification:×200) Rabbit IgG Purified Hu, Ms, Rt E, ICC/IF
0.1 ml / €325.00
  OriGene Technologies, Inc.

VEGFR-1 / Flt-1 antibody

Predicted band size: 151 kDa . Positive control: Molt-4, Hela, MCF-7 and PC12 cells lysate. Recommended dilution: 1/ 500-1000. (Gel: 8%SDS-PAGE Lane1,2,3,4: Molt-4, Hela, MCF-7 and PC12 cells Lysates: 30 ug per lane Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

VEGFR-1 / Flt-1 antibody

VEGFR-1 / Flt-1 Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

VEGFR-1 / Flt-1 antibody

Western blot analysis of extracts of MCF-7 cell line, using VEGFR1 antibody. Rabbit IgG Purified Hu
0.1 mg / €325.00
  OriGene Technologies, Inc.

VEGFR-1 / Flt-1 antibody

Western Blot: VEGF Receptor 1 Antibody [TA336313] - Chimeric CSF-1R/VEGFR-2 detection in transfected lysates. Rabbit Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

VEGFR-1 / Flt-1 (N-term) antibody

Anti-VEGFR1 antibody IHC of human placenta, fetal capillary endothelial cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Bear, Can, Eq, Hu, Mky, Ms, Op, Platypus, Rt P
50 µg / €379.00
  OriGene Technologies, Inc.

VEGFR-1 / Flt-1 (C-term) antibody

Anti-VEGFR1 antibody IHC of human placenta, fetal capillary endothelial cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Gorilla, Hu, Mky P
50 µg / €379.00
  OriGene Technologies, Inc.

VEGFR-1 / Flt-1 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY FLT1 (RC224406, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-FLT1. Mouse IgG1 OTI8G6 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

VEGFR-1 / Flt-1 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY FLT1 (RC224406, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-FLT1. Mouse IgG1 OTI11G5 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

VEGFR-1 / Flt-1 antibody

VEGFR-1 / Flt-1 Mouse IgG1 Flt-19 Supernatant Hu C, E, IP
0.1 mg / €430.00
  Acris Antibodies GmbH

VEGFR-1 / Flt-1 antibody

Western blot analysis using FLT1 mouse mAb against extracellular domain of human FLT1. Mouse IgG1 3D10 Ascites Hu E, WB
0.1 ml / €400.00
  Acris Antibodies GmbH

VEGFR-1 / Flt-1 antibody

VEGFR-1 / Flt-1 Mouse IgG1 V12 Purified Hu C, ICC/IF, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

VEGFR-1 / Flt-1 antibody

VEGFR-1 / Flt-1 Mouse IgG1 FLT1/658 Purified Hu
0.2 mg / €390.00
  Acris Antibodies GmbH

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