VEGFR-1 / Flt-1 antibody

Principal name

VEGFR-1 / Flt-1 antibody

Alternative names for VEGFR-1 / Flt-1 antibody

VEGFR1, FLT1, FLT, FRT, VEGF Receptor 1, Vascular endothelial growth factor receptor 1, Vascular permeability factor receptor, Tyrosine-protein kinase receptor FLT, Tyrosine-protein kinase FRT, Fms-like tyrosine kinase 1

SwissProt ID

P17948 (Human), P35969 (Mouse), P53767 (Rat), Q8QHL3 (Chick)

Gene ID

2321 (FLT1), 14254 (Flt1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), African clawed frog, Chk (Chicken), Mky (Monkey), Por (Porcine), Sh (Sheep), Can (Canine), Eq (Equine), Op (Opossum), Bear, Gorilla

Available hosts

Rabbit, Mouse, Sheep, Chicken, Rat

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Immunoprecipitation (IP), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F), Frozen Sections (C), ELISA (detection) (E(detection))

Background of VEGFR-1 / Flt-1 antibody

VEGF Receptor 1 (vascular endothelial growth factor receptor 1 or VEGFR1; also called Flt1 in mouse) is a tyrosine-protein kise which acts as a cell-surface receptor for VEGFA, VEGFB and PGF ligands for playing an essential role in the embryonic vasculature development and regulation of angiogenesis (normal as well as cancerous tissues), cell survival, migration, macrophage function, chemotaxis, and tumor invasion. VEGFR1 is a 180-185 kD glycoprotein expressed primarily in vascular endothelial cells and also found in a wide range of non-endothelial cells, such as monocytes and macrophages, human trophoblasts, rel mesangial cells, vascular smooth muscle cells, dendritic cells and different human tumour cell types. Interestingly, VEGFR1 acts as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells, whereas it promotes endothelial cell proliferation, survival and angiogenesis in adults. VEGFR1 expression is regulated by hypoxia through HREs in VEGFR1 promoter. It exists in an ictive conformation in the absence of bound ligand and binding of VEGFA, VEGFB or PGF leads to its dimerization followed by tyrosine residue autophosphorylation mediated activation. VEGFR1 phosphorylation sites includes Tyr794, Tyr1169, Tyr1213, Tyr1242, Tyr1327, Tyr1333 etc. and VEGFR1 phosphorylation pattern depends on the ligand, e.g. PlGF, but not VEGFA, induces phosphorylation of Tyr1309. VEGFR1 has been shown to exert its diverse biological activities through its effects on multiple sigl transduction pathways including VEGF, KDR, PLCG, PI3K, MAPK etc.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

VEGFR-1 / Flt-1 antibody

Standard ELISA assay with coating of 2.5 µg/ml Mouse sFlt-1-Fc using anti Human Flt-1 antibodies Mouse IgG1 FLTEWC Purified Hu, Ms E, ICC/IF, IP, WB
0.1 mg / €350.00
  OriGene Technologies GmbH

VEGFR-1 / Flt-1 antibody

Immunofluorescence staining (green) using Polyclonal antibody directed against the C-terminal end of native soluble VEGFR-1/Flt-1 Cat.-No DP3522 (Left panel) and Monoclonal antibody directed against the extracellular domain of the membrane-bound VEGFR-1/Flt-1 Cat.-No DM3507 (Right panel). You see two neighboring sections of a Human Vein (V), located near a hemangioma. The antibody against the soluble VEGFR-1/Flt-1 marked single cells (arrows) within the media and adventitia of the vein. The antibody against the membrane-bound VEGFR-1/Flt-1 marked single cells (arrows) and the endothelium (arrowhead) of the vein. Cell nuclei are stained with Dapi (blue).  The experiment was performed by K. Butler and J. Wilting, University Göttingen, Germany. Mouse IgG1 FLTEWI (EWI) Purified Hu, Ms E, ICC/IF, IP, WB
0.1 mg / €330.00
  OriGene Technologies GmbH

VEGFR-1 / Flt-1 antibody

Western analysis of recombinant human and mouse soluble VEGF receptors using a monoclonal antibody directed against human recombinant sFlt-1(D5). There is no cross reactivity with mouse sFlt-1(D7)-Fc as well as with human and mouse sKDR and human sFLT-4 visible. Mouse IgG1 FLTEIC Purified Hu E, F, ICC/IF, WB
0.1 mg / €350.00
  OriGene Technologies GmbH

VEGFR-1 / Flt-1 antibody

Western analysis of recombinant Human and Mouse soluble VEGFR-1/Flt-1. Mouse IgG1 FLTEWF Purified Hu, Ms E, ICC/IF, IP, WB
0.1 mg / €330.00
  OriGene Technologies GmbH

4 Item(s)

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