VEGFR-1 / Flt-1 antibody

Principal name

VEGFR-1 / Flt-1 antibody

Alternative names for VEGFR-1 / Flt-1 antibody

VEGFR1, FLT1, FLT, FRT, VEGF Receptor 1, Vascular endothelial growth factor receptor 1, Vascular permeability factor receptor, Tyrosine-protein kinase receptor FLT, Tyrosine-protein kinase FRT, Fms-like tyrosine kinase 1

SwissProt ID

P17948 (Human), P35969 (Mouse), P53767 (Rat), Q8QHL3 (Chick)

Gene ID

2321 (FLT1), 14254 (Flt1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), African clawed frog, Chk (Chicken), Mky (Monkey), Por (Porcine), Sh (Sheep), Can (Canine), Eq (Equine), Op (Opossum), Bear, Gorilla

Available hosts

Rabbit, Mouse, Sheep, Chicken, Rat

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Immunoprecipitation (IP), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F), Frozen Sections (C), ELISA (detection) (E(detection))

Background of VEGFR-1 / Flt-1 antibody

VEGF Receptor 1 (vascular endothelial growth factor receptor 1 or VEGFR1; also called Flt1 in mouse) is a tyrosine-protein kise which acts as a cell-surface receptor for VEGFA, VEGFB and PGF ligands for playing an essential role in the embryonic vasculature development and regulation of angiogenesis (normal as well as cancerous tissues), cell survival, migration, macrophage function, chemotaxis, and tumor invasion. VEGFR1 is a 180-185 kD glycoprotein expressed primarily in vascular endothelial cells and also found in a wide range of non-endothelial cells, such as monocytes and macrophages, human trophoblasts, rel mesangial cells, vascular smooth muscle cells, dendritic cells and different human tumour cell types. Interestingly, VEGFR1 acts as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells, whereas it promotes endothelial cell proliferation, survival and angiogenesis in adults. VEGFR1 expression is regulated by hypoxia through HREs in VEGFR1 promoter. It exists in an ictive conformation in the absence of bound ligand and binding of VEGFA, VEGFB or PGF leads to its dimerization followed by tyrosine residue autophosphorylation mediated activation. VEGFR1 phosphorylation sites includes Tyr794, Tyr1169, Tyr1213, Tyr1242, Tyr1327, Tyr1333 etc. and VEGFR1 phosphorylation pattern depends on the ligand, e.g. PlGF, but not VEGFA, induces phosphorylation of Tyr1309. VEGFR1 has been shown to exert its diverse biological activities through its effects on multiple sigl transduction pathways including VEGF, KDR, PLCG, PI3K, MAPK etc.

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Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

VEGFR-1 / Flt-1 (C-term DDK tag, transcript variant 1)

  Recombinant protein of human fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) (FLT1), transcript variant 1, residues 27-758aa, with C-terminal DDK tag, expressed in sf9, 20ug  
VEGFR-1 / Flt-1 Human > 80 %
Preparation: .
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
SF9 cells
20 µg / €411.00
  OriGene Technologies, Inc.

VEGFR-1 / Flt-1

SDS-PAGE analysis of recombinant human soluble VEGFR-1 produced in insect cells. Sample was loaded in 15% SDS-polyacrylamide gel under reducing condition and stained with Silver stain. Human Purified > 95 % pure by SDS-PAGE and visualised by silver stain Insect cells
5 µg / €200.00
  OriGene Technologies GmbH

VEGFR-1 / Flt-1

SDS-PAGE analysis of recombinant human soluble VEGFR-1 produced in insect cells. Sample was loaded in 15% SDS-polyacrylamide gel under reducing condition and stained with Silver stain. Human Purified > 95 % pure by SDS-PAGE and visualised by silver stain Insect cells
20 µg / €280.00
  OriGene Technologies GmbH

VEGFR-1 / Flt-1 (D1-D4)

SDS-PAGE analysis of recombinant human soluble VEGFR-1D1-4 produced in insect cells. Sample was loaded in 10% SDS-polyacrylamide gel under reducing condition and stained with Silver stain. Human Purified > 90 % by SDS-PAGE and visualised by silver stain. Insect cells
5 µg / €220.00
  OriGene Technologies GmbH

VEGFR-1 / Flt-1 (D1-D4)

SDS-PAGE analysis of recombinant human soluble VEGFR-1D1-4 produced in insect cells. Sample was loaded in 10% SDS-polyacrylamide gel under reducing condition and stained with Silver stain. Human Purified > 90 % by SDS-PAGE and visualised by silver stain. Insect cells
20 µg / €300.00
  OriGene Technologies GmbH

VEGFR-1 / Flt-1 (Fc Chimera)

SDS-PAGE analysis of recombinant human soluble VEGFR-1/Fc produced in insect cells. Sample was loaded in 10% SDS-polyacrylamide gel under reducing condition and stained with Coomassie blue. Human Purified > 90 % by SDS-PAGE and visualised by silver stain. Insect cells
10 µg / €170.00
  OriGene Technologies GmbH

VEGFR-1 / Flt-1 (D1-7) (Fc Chimera)

SDS-PAGE analysis of recombinant human soluble VEGFR-1/Fc produced in insect cells. Sample was loaded in 10% SDS-polyacrylamide gel under reducing condition and stained with Coomassie blue. Human Purified > 90 % by SDS-PAGE and visualised by silver stain. Insect cells
50 µg / €290.00
  OriGene Technologies GmbH

VEGFR-1 / Flt-1 (D1-D5)

Inhibition of the VEGF165-induced proliferation of HUVE cells by recombinant human endogenous sFlt-1 and sFlt-1 constructs. HUVECs were stimulated with 10 ng/ml VEGF165, the soluble receptors were added with a 100X excess. Human Purified > 90 % pure by SDS-PAGE and Silver stain Insect cells
5 µg / €200.00
  OriGene Technologies GmbH

VEGFR-1 / Flt-1 (D1-D5)

Inhibition of the VEGF165-induced proliferation of HUVE cells by recombinant human endogenous sFlt-1 and sFlt-1 constructs. HUVECs were stimulated with 10 ng/ml VEGF165, the soluble receptors were added with a 100X excess. Human Purified > 90 % pure by SDS-PAGE and Silver stain Insect cells
20 µg / €280.00
  OriGene Technologies GmbH

VEGFR-1 / Flt-1 (D1-D3)

Inhibition of the VEGF165-induced proliferation of HUVE cells by recombinant human endogenous sFlt-1 and sFlt-1 constructs. HUVECs were
stimulated with 10 ng/ml VEGF165, the soluble receptors were added with a 100X excess. Human Purified > 90 % by SDS-PAGE and visualised by silver stain Insect cells
5 µg / €220.00
  OriGene Technologies GmbH

VEGFR-1 / Flt-1 (D1-D3)

Inhibition of the VEGF165-induced proliferation of HUVE cells by recombinant human endogenous sFlt-1 and sFlt-1 constructs. HUVECs were
stimulated with 10 ng/ml VEGF165, the soluble receptors were added with a 100X excess. Human Purified > 90 % by SDS-PAGE and visualised by silver stain Insect cells
20 µg / €300.00
  OriGene Technologies GmbH

ELISA Kits

Catalog No.    

Human sVEGFR1/sFLT1 ELISA Kit

Human sVEGFR1/sFLT1 ELISA Kit  
1 kit / €500.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, FLT1 (mGFP-tagged) - Human fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) (FLT1), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, FLT1 (mGFP-tagged) - Human fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) (FLT1), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €2,680.00
  OriGene Technologies, Inc.

Lenti ORF particles, FLT1 (mGFP-tagged)-Human fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) (FLT1), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, FLT1 (mGFP-tagged)-Human fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) (FLT1), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,110.00
  OriGene Technologies, Inc.

Lenti ORF particles, FLT1 (mGFP-tagged)-Human fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) (FLT1), transcript variant 4, 200 uL, >10^7 TU/mL

Lenti ORF particles, FLT1 (mGFP-tagged)-Human fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) (FLT1), transcript variant 4, 200 uL, >10^7 TU/mL  
200 µl / €1,240.00
  OriGene Technologies, Inc.

Lenti ORF particles, FLT1 (Myc-DDK tagged) - Human fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) (FLT1), transcript variant 1 , 200 uL, >10^7 TU/mL

Lenti ORF particles, FLT1 (Myc-DDK tagged) - Human fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) (FLT1), transcript variant 1 , 200 uL, >10^7 TU/mL  
200 µl / €2,420.00
  OriGene Technologies, Inc.

Lenti ORF particles, FLT1 (Myc-DDK-tagged)-Human fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) (FLT1), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, FLT1 (Myc-DDK-tagged)-Human fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) (FLT1), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,000.00
  OriGene Technologies, Inc.

Lenti ORF particles, FLT1 (Myc-DDK-tagged)-Human fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) (FLT1), transcript variant 4, 200 uL, >10^7 TU/mL

Lenti ORF particles, FLT1 (Myc-DDK-tagged)-Human fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) (FLT1), transcript variant 4, 200 uL, >10^7 TU/mL  
200 µl / €1,110.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Flt1 (GFP-tagged) - Mouse FMS-like tyrosine kinase 1 (cDNA clone MGC:36074 IMAGE:5368921), 200 uL, >10^7 TU/mL

Lenti ORF particles, Flt1 (GFP-tagged) - Mouse FMS-like tyrosine kinase 1 (cDNA clone MGC:36074 IMAGE:5368921), 200 uL, >10^7 TU/mL  
200 µl / €1,470.00
  OriGene Technologies, Inc.

Lenti ORF particles, Flt1 (GFP-tagged) - Mouse FMS-like tyrosine kinase 1 (Flt1), 200 uL, >10^7 TU/mL

Lenti ORF particles, Flt1 (GFP-tagged) - Mouse FMS-like tyrosine kinase 1 (Flt1), 200 uL, >10^7 TU/mL  
200 µl / €2,360.00
  OriGene Technologies, Inc.

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