VEGFR-3 / Flt-4 antibody

Principal name

VEGFR-3 / Flt-4 antibody

Alternative names for VEGFR-3 / Flt-4 antibody

VEGFR3, FLT4, VEGF Receptor 3, Vascular endothelial growth factor receptor 3, Tyrosine-protein kinase receptor FLT4

SwissProt ID

P35916 (Human), P35917 (Mouse), Q5MD89 (Danre), Q91ZT1 (Rat)

Gene ID

2324 (FLT4), 14257 (Flt4), 7424 (VEGFC)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Macaque

Available hosts

Rabbit, Mouse, Goat, Rat, Chicken

Available applications

Frozen Sections (C), Paraffin Sections (P), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Flow Cytometry (F), Functional assay (FN)

Background of VEGFR-3 / Flt-4 antibody

Vascular endothelial growth factors (VEGFs) are a family of closely related growth factors having a conserved pattern of eight cysteine residues and sharing common VEGF receptors. VEGFs stimulate the proliferation of endothelial cells, induce angiogenesis, and increase vascular permeability in both large and small vessels. The mitogenic activity of the VEGFs appears to be mediated by specific VEGF receptors. VEGF Receptor 3 is one of the five receptor tyrosine kinases (RTKs) (VEGF Receptor 1/Flt1, VEGF Receptor 2/KDR/Flk1, VEGF Receptor 3/Flt4, tie1 and tek/tie2) whose expression is almost exclusively restricted to endothelial cells. Tie1 and tek/tie2 are a class of RTKs containing two immunoglobulin-like domains, three EGF homology domains and three fibronectin type III domains in their extracellular regions. VEGF Receptor 1/Flt1, VEGF Receptor 2/KDR/Flk1, and VEGF Receptor 3/Flt4 are members of the class III subfamily of RTKs containing seven immunoglobulin-like repeats in their extracellular domains. All five of the receptor tyrosine kinases (RTKs) play central roles in vasculogenesis and angiogenesis. Mature native mouse VEGF Receptor 3 (Flt4) is composed of a 751 amino acid residue extracellular domain, a 22 amino acid residue transmembrane domain, and a 565 amino acid residue cytoplasmic domain. Recombinant mature mouse VEGF Receptor 3/Fc is a disulfidelinked dimeric protein. Based on N-terminal sequencing, recombinant mouse VEGF Receptor 3/Fc has Met 17 at the amino-terminus. The amino acid sequence of mouse VEGF Receptor 3 is 88 % identical to human VEGF Receptor 3. VEGF Receptor 3 is a specific marker for lymphatic vessels. In adults, VEGF Receptor 3 expression is restricted to endothelial cells of the lymphatic vessels. It has also been detected on some high endothelial venules, in embryonic prelymphatic blood vessels, in some tumor blood vessels, and in certain hematopoietic and leukemia cells. The predominant role of VEGF Receptor 3 is its involvement in the development of the lymphatic vessel system. Both VEGFC and VEGFD bind and activate the receptors, VEGF Receptor 3 and VEGF Receptor 2.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

VEGFR-3 / Flt-4 antibody

VEGFR-3 / Flt-4 Mouse IgG1 3C3 Biotin Hu E, WB
50 µg / €350.00
  Acris Antibodies GmbH

VEGFR-3 / Flt-4 antibody

Immunofluorescence staining of human VEGFR-3/FLT-4 (red) in hFlt4-transfected MG63 cells. Monoclonal mouse anti-human FLT-4  clone 9D9 (Cat.-No DM3512P) and polyclonal rabbit anti-human FLT-4 (D) Cat.-No DP3511: A and C are negative control with secondary antibody only; B (mAb) and D (pAb) with specific antibodies against human FLT-4.The experiment was performed by the research group of Dr. Wolfgang Holnthoner, Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Austrian Cluster for Tissue Regeneration, Donaueschingenstrasse 13, A-1200 Vienna, Austria. Mouse IgG1 (3C3) 9D9 Aff - Purified Hu C, E, ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

VEGFR-3 / Flt-4 antibody

VEGFR-3 / Flt-4 Rabbit Purified Hu C, P
1 ml / €630.00
  Acris Antibodies GmbH

VEGFR-3 / Flt-4 antibody

VEGFR-3 / Flt-4 Rabbit Purified Hu P
0.5 ml / €410.00
  Acris Antibodies GmbH

VEGFR-3 / Flt-4 (C-term) antibody

AP15558PU VEGFR-3/Flt-4 antibody staining of Human Placenta. Rabbit Purified Hu, Ms, Rt P, WB
0.5 ml / €360.00
  Acris Antibodies GmbH

VEGFR-3 / Flt-4 (C-term) antibody

AP15558PU VEGFR-3/Flt-4 antibody staining of Human Placenta. Rabbit Purified Hu, Ms, Rt P, WB
1 ml / €440.00
  Acris Antibodies GmbH

VEGFR-3 / Flt-4 (C-term) antibody

AP15558PU VEGFR-3/Flt-4 antibody staining of Human Placenta. Rabbit Purified Hu, Ms, Rt P, WB
0.1 ml / €180.00
  Acris Antibodies GmbH

VEGFR-3 / Flt-4 antibody

Predicted cell location: Cytoplasm. Positive control: Hela and HepG2 cell. Recommended dilution: 1/100-500 The image is immunocytochemistry of methanol-fixed Hela cell  using FLT4 antibody at dilution 1/100, the secondary antibody is FITC conjugated Goat Anti-Rabbit IgG at dilution 1/200, blue is nucleus staining by Dapi. (Original magnification:×200) Rabbit IgG Purified Hu, Ms, Rt E, ICC/IF
0.1 ml / €325.00
  OriGene Technologies, Inc.

VEGFR-3 / Flt-4 antibody

Western blot analysis of extracts of HUVEC cell line, using FLT4 antibody. Rabbit IgG Purified Hu
0.1 mg / €325.00
  OriGene Technologies, Inc.

VEGFR-3 / Flt-4 antibody

Western blot analysis of extracts from HUVEC cells using VEGFR-3 Antibody (right) and the same antibody preincubated with blocking peptide Rabbit IgG Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

VEGFR-3 / Flt-4 antibody

ELISA: VEGF Receptor 3 Antibody Rabbit IgG Purified Hu E
0.1 mg / €325.00
  OriGene Technologies, Inc.

VEGFR-3 / Flt-4 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY FLT4 (RC214285, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-FLT4. Mouse IgG1 OTI1G2 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

VEGFR-3 / Flt-4 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY FLT4 (RC214285, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-FLT4. Mouse IgG1 OTI1G7 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

VEGFR-3 / Flt-4 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY FLT4 (RC214285, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-FLT4. Mouse IgG1 OTI8C2 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

VEGFR-3 / Flt-4 antibody

Western blot analysis using FLT4 antibody Cat.-No AM06464SU-N against FLT4(AA: 25-330)-hIgGFc transfected HEK293 cell lysate. Mouse IgG1 4H4 Ascites Hu E, WB
0.1 ml / €400.00
  Acris Antibodies GmbH

VEGFR-3 / Flt-4 antibody

Figure 2. Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with VGFR3 Monoclonal Antibody (Cat.#AM11070PU-N), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Mouse IgG1 44CT92.4.4 Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

VEGFR-3 / Flt-4 antibody

Immunofluorescence staining of VEGFR-3/FLT4 in Mouse primary endothelial cells (SnoMec) with monoclonal Rat anti-Mouse VEGFR-3/FLT4 #7A3 Cat.-No AM20378PU-N (upper panel). Control with goat anti-rat ALEXA Flour 488 (lower panel). Rat IgG1 7A3 Purified Ms ICC/IF, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

VEGFR-3 / Flt-4 antibody

Western analysis of recombinant human soluble VEGFR3/FLT-4 using a Mouse anti-Human FLT-4 antibody (Cat.-No AM20379PU-N). Mouse IgG1 2E11 Aff - Purified Hu C, E, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

VEGFR-3 / Flt-4 antibody

VEGFR-3 / Flt-4 Rat IgG2 5F63 Purified Ms P, WB
0.1 mg / €440.00
  Acris Antibodies GmbH

VEGFR-3 / Flt-4 (1279-1283) antibody

Western blot analysis of extracts from HUVEC cells using VEGFR-3 Antibody AP26050PU-N and the same antibody preincubated with blocking peptide. Rabbit Aff - Purified Hu WB
0.1 ml / €270.00
  Acris Antibodies GmbH

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