VEGFR-3 / Flt-4 antibody

Principal name

VEGFR-3 / Flt-4 antibody

Alternative names for VEGFR-3 / Flt-4 antibody

VEGFR3, FLT4, VEGF Receptor 3, Vascular endothelial growth factor receptor 3, Tyrosine-protein kinase receptor FLT4

SwissProt ID

P35916 (Human), P35917 (Mouse), Q5MD89 (Danre), Q91ZT1 (Rat)

Gene ID

2324 (FLT4), 14257 (Flt4), 114110

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Macaque

Available hosts

Rabbit, Mouse, Rat, Chicken

Available applications

Frozen Sections (C), Paraffin Sections (P), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP)

Background of VEGFR-3 / Flt-4 antibody

Recombinant human soluble Vascular Endothelial Growth Factor Receptor-3 (sVEGFR-3/FLT-4) was fused with a carboxy-terminal 6X histidine-tag. All three VEGF receptors belong to the class III subfamily of receptor tyrosine kinases (RTKs) characterised by the seven immunoglobulin-like loops in the extracellular domain. The expression of VEGFR-1 to -3 is almost exclusively restricted to hematopoietic precursor cells, vascular and lymphatic endothelial cells and to the monocyte/macrophage lineage. They play key roles in vasculogenesis, hematopoiesis, angiogenesis and lymphangiogenesis. The FLT-4 cDNA encodes a 1298 amino acid (aa) residue precursor protein with a 23 aa residue signal peptide. Mature VEGFR-3/FLT-4 is composed of a 751 aa residue extracellular domain, a 22 aa transmembrane domain and a 482 aa residue cytoplasmic domain. Both VEGF family members VEGF-C and VEGF-D have been shown to bind and activate VEGFR-3/FLT-4. The Flt-4 gene is widely expressed in the early embryo but becomes restricted to the lymphatic endothelial a latter stages of development. It is important for lymphangiogenesis.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

VEGFR-3 / Flt-4 antibody

Immunofluorescence staining of human VEGFR-3/FLT-4 (red) in hFlt4-transfected MG63 cells. Monoclonal mouse anti-human FLT-4  clone 9D9 (Cat.-No DM3512P) and polyclonal rabbit anti-human FLT-4 (D) Cat.-No DP3511: A and C are negative control with secondary antibody only; B (mAb) and D (pAb) with specific antibodies against human FLT-4.The experiment was performed by the research group of Dr. Wolfgang Holnthoner, Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Austrian Cluster for Tissue Regeneration, Donaueschingenstrasse 13, A-1200 Vienna, Austria. Mouse IgG1 (3C3) 9D9 Aff - Purified Hu C, E, ICC/IF, P, WB
0.1 mg / €350.00
  OriGene Technologies GmbH

VEGFR-3 / Flt-4 antibody

FACS analysis with primary human dermal lymphatic endothelial cells (HDLEC). Rabbit Azide Free Hu E, IP, WB
0.2 mg / €290.00
  OriGene Technologies GmbH

VEGFR-3 / Flt-4 antibody

FACS analysis with primary human dermal lymphatic endothelial cells (HDLEC). Rabbit IgG Aff - Purified Hu C, E, F, IP, WB
50 µg / €300.00
  OriGene Technologies GmbH

VEGFR-3 / Flt-4 antibody

FACS analysis with primary human dermal lymphatic endothelial cells (HDLEC). Rabbit Azide Free Hu E, IP, WB
0.1 mg / €250.00
  OriGene Technologies GmbH

4 Item(s)

per page
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