VHL antibody
Principal name
VHL antibody
Alternative names for VHL antibody
Von Hippel-Lindau disease tumor suppressor, Protein G7
Ncbi ID
9606, NP_000542, NM_198156, NP_000542.1, NP_033533.1, NM_009507, NM_052801, NM_000551
Available reactivities
Available hosts
Available applications
Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Frozen Sections (C), Immunoprecipitation (IP)
Background of VHL antibody
The Von Hippel-Lindau (VHL) protein is a substrate recognition component of an E3 ubiquitin ligase complex containing elongin BC (TCEB1 and TCEB2), cullin 1 (CUL1), and RING-box protein 1 (RBX1). VHL protein has been shown to exist as three distinct isoforms resulting from altertively spliced transcript variants. Loss of VHL protein function results in a domintly inherited familial cancer syndrome that manifests as angiomas of the reti, hemangioblastomas of the central nervous system, rel clear-cell carcinomas and pheochromocytomas. Under normoxic conditions, VHL directs the ubiquitylation and subsequent proteosomal degradation of the hypoxia inducible factor HIF alpha, maintaining very low levels of HIF alpha in the cell. Cellular exposure to hypoxic conditions, or loss of VHL protein function, results in increased HIF alpha protein levels and increased expression of HIF-induced gene products, many of which are angiogenesis factors such as vascular endothelial growth factor (VEGF). Thus, loss of VHL protein function is believed to contribute to the formation of highly vascular neoplasias. In addition to HIF alpha, VHL is known to regulate the ubiquitylation of several other proteins, including tat-binding protein 1 (TBP-1), the atypical protein kise C lambda (aPKC), and two subunits of the multiprotein R Polymerase II complex (RPB1 and RPB7). Interactions with elongin BC, RPB1, RPB7 and the pVHL-associated KRAB-A domain containing protein (VHLaK) suggest that VHL may also play a more direct role in transcriptiol repression.




































- Quick-Filters:
- Highly Validated (1)
Primary Antibodies
Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
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TA506222 | VHL antibody |
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VHL (Von Hippel Lindau) mouse monoclonal antibody, clone OTI1E1 (formerly 1E1) | |||||||
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Mouse | IgG2b | OTI1E1 | Purified | Hu | P, WB |
0.1 ml /
€379.00
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OriGene Technologies, Inc. | |||||||
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Top Selling product! Highly validated antibody! |
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TA303127 | VHL antibody |
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Goat Polyclonal Antibody against VHL | |||||||
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Goat | Aff - Purified | Can, Hu, Ms, Rt | E, WB |
0.1 mg /
€360.00
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OriGene Technologies, Inc. | |||||||
TA321159 | VHL antibody |
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Anti-VHL Rabbit Polyclonal Antibody | |||||||
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Rabbit | IgG | Purified | Hu, Ms, Rt | E, P |
0.1 ml /
€335.00
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OriGene Technologies, Inc. | |||||||
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TA321160 | VHL antibody |
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Anti-VHL Rabbit Polyclonal Antibody | |||||||
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Rabbit | IgG | Purified | Hu, Ms, Rt | E, P |
0.1 ml /
€335.00
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OriGene Technologies, Inc. | |||||||
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TA324848 | VHL (N-term) antibody |
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Rabbit polyclonal VHL Antibody (N-term) | |||||||
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Rabbit | Hu | WB |
0.4 ml /
€410.00
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OriGene Technologies, Inc. | |||||||
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TA326834 | VHL antibody |
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Rabbit anti-VHL Polyclonal Antibody | |||||||
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Rabbit | IgG | Purified | Hu, Ms, Rt | WB |
0.1 mg /
€335.00
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OriGene Technologies, Inc. | |||||||
TA327866 | VHL antibody |
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Rabbit Polyclonal VHL Antibody | |||||||
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Rabbit | IgG | Purified | Hu, Ms, Rt | P |
0.1 ml /
€335.00
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OriGene Technologies, Inc. | |||||||
AP17826PU-N | VHL (C-term) antibody |
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Rabbit | Hu | WB |
0.4 ml /
€370.00
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Acris Antibodies GmbH | |||||||
B8450-1 | VHL antibody |
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Rabbit | Aff - Purified | Hu, Ms, Rt | E, P |
50 µg /
€230.00
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Assay Biotech | |||||||
B8450-2 | VHL antibody |
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Rabbit | Aff - Purified | Hu, Ms, Rt | E, P |
0.1 mg /
€330.00
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Assay Biotech |
CRISPR
Catalog No. | Species | Donor Vector | |
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KN208875 | VHL - human gene knockout kit via CRISPR |
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Human | GFP-Puro |
1 kit /
€1,290.00
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OriGene Technologies, Inc. | |||
KN208875BN | VHL - human gene knockout kit via CRISPR |
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Human | mBFP-Neo |
1 kit /
€1,290.00
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OriGene Technologies, Inc. | |||
KN208875LP | VHL - human gene knockout kit via CRISPR |
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Human | Luciferase-Puro |
1 kit /
€1,290.00
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OriGene Technologies, Inc. | |||
KN208875RB | VHL - human gene knockout kit via CRISPR |
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Human | RFP-BSD |
1 kit /
€1,290.00
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OriGene Technologies, Inc. | |||
KN318888 | Vhl - mouse gene knockout kit via CRISPR |
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Mouse | GFP-Puro |
1 kit /
€1,290.00
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OriGene Technologies, Inc. | |||
KN318888BN | Vhl - mouse gene knockout kit via CRISPR |
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Mouse | mBFP-Neo |
1 kit /
€1,290.00
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OriGene Technologies, Inc. | |||
KN318888LP | Vhl - mouse gene knockout kit via CRISPR |
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Mouse | Luciferase-Puro |
1 kit /
€1,290.00
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OriGene Technologies, Inc. | |||
KN318888RB | Vhl - mouse gene knockout kit via CRISPR |
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Mouse | RFP-BSD |
1 kit /
€1,290.00
|
OriGene Technologies, Inc. |
Proteins & Growth Factors
Catalog No. | Species | Pres. | Purity | Source | |
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TP316151 | VHL (transcript variant 1) |
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Recombinant protein of human von Hippel-Lindau tumor suppressor (VHL), transcript variant 1 | |||||
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Human | > 80 % Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps. Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining. |
HEK293 cells |
20 µg /
€438.00
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OriGene Technologies, Inc. | |||||
TP760451 | VHL (full length, N-term HIS tag, transcript variant 1) |
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Purified recombinant protein of Human von Hippel-Lindau tumor suppressor (VHL), transcript variant 1, full length, with N-terminal HIS tag, expressed in E.Coli, 50ug | |||||
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Human | > 80 % Preparation: . Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining. |
E. coli |
50 µg /
€199.00
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OriGene Technologies, Inc. |