Vitamin Z / PROZ antibody

Principal name

Vitamin Z / PROZ antibody

Alternative names for Vitamin Z / PROZ antibody

Vitamin K-dependent protein Z

SwissProt ID

P00744 (Bovin), P22891 (Human), Q9CQW3 (Mouse)

Gene ID

8858 (PROZ), 66901 (Proz)

Available reactivities

Hu (Human)

Available hosts

Mouse, Rabbit

Available applications

ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P)

Background of Vitamin Z / PROZ antibody

PROZ protein Z, vitamin K-dependent plasma glycoprotein. It is 62 kDa large and 396 amino acids long. It has four domains: a gla-rich region, two EGF-like domains and a trypsin-like domain. It lacks the serine residue that would make it catalytically active as a serine protease. It is a member of the coagulation cascade, the group of blood proteins that leads to the formation of blood clots. It is vitamin K-dependent, and its functionality is therefore impaired in warfarin therapy. It is a glycoprotein. Although it is not enzymatically active, it is structurally related to several serine proteases of the coagulation cascade: factors VII, IX, X and protein C. The carboxyglutamate residues (which require vitamin K) bind protein Z to phospholipid surfaces. The main role of protein Z appears to be the degradation of factor Xa. This is done by protein Z-related protease inhibitor (ZPI), but the reaction is accelerated 1000-fold by the presence of protein Z. Oddly, ZPI also degrades factor XI, but this reaction does not require the presence of protein Z. In some studies, deficiency states have been associated with a propensity to thrombosis. Others, however, link it to bleeding tendency; there is no clear explanation for this, as it acts physiologically as an inhibitor, and deficiency would logically have led to a predisposition for thrombosis.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Vitamin Z / PROZ antibody

  PROZ mouse monoclonal antibody, clone OTI4D5 (formerly 4D5)  
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-PROZ mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA806759) Mouse IgG2a OTI4D5 Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Vitamin Z / PROZ antibody

Uterus, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG1 2B4 Ascites Hu E, P, WB
50 µl / €470.00
  Acris Antibodies GmbH

Vitamin Z / PROZ antibody

  PROZ mouse monoclonal antibody, clone OTI3A11 (formerly 3A11)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PROZ (RC210379, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PROZ. Mouse IgG2a OTI3A11 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Vitamin Z / PROZ antibody

  PROZ mouse monoclonal antibody, clone OTI4F1 (formerly 4F1)  
Immunohistochemical staining of paraffin-embedded Human liver tissue within the normal limits using anti-PROZ mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA806675) Mouse IgG1 OTI4F1 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Vitamin Z / PROZ antibody

  PROZ mouse monoclonal antibody, clone OTI1A11 (formerly 1A11)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PROZ (RC210379, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PROZ. Mouse IgG2a OTI1A11 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Vitamin Z / PROZ antibody

  PROZ mouse monoclonal antibody, clone OTI3E5 (formerly 3E5)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PROZ (RC210379, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PROZ.(1:2000) Mouse IgG2a OTI3E5 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Vitamin Z / PROZ antibody

  PROZ mouse monoclonal antibody, clone OTI1C10 (formerly 1C10)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PROZ (RC210379, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PROZ.(1:2000) Mouse IgG2a OTI1C10 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Vitamin Z / PROZ antibody

Western blot analysis using PROZ antibody Cat.-No AM06353SU-N against human plasma (Lane 1). Mouse IgG1 2B4 Ascites Hu E, WB
0.1 ml / €400.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

PROZ - human gene knockout kit via CRISPR

PROZ - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

PROZ - human gene knockout kit via CRISPR

PROZ - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

PROZ - human gene knockout kit via CRISPR

PROZ - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

PROZ - human gene knockout kit via CRISPR

PROZ - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proz - mouse gene knockout kit via CRISPR

Proz - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Proz - mouse gene knockout kit via CRISPR

Proz - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proz - mouse gene knockout kit via CRISPR

Proz - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proz - mouse gene knockout kit via CRISPR

Proz - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

PROZ overexpression lysate

PROZ overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, PROZ (mGFP-tagged) - Human protein Z, vitamin K-dependent plasma glycoprotein (PROZ), 200 uL, >10^7 TU/mL

Lenti ORF particles, PROZ (mGFP-tagged) - Human protein Z, vitamin K-dependent plasma glycoprotein (PROZ), 200 uL, >10^7 TU/mL  
200 µl / €990.00
  OriGene Technologies, Inc.

Lenti ORF particles, PROZ (Myc-DDK tagged) - Human protein Z, vitamin K-dependent plasma glycoprotein (PROZ) , 200 uL, >10^7 TU/mL

Lenti ORF particles, PROZ (Myc-DDK tagged) - Human protein Z, vitamin K-dependent plasma glycoprotein (PROZ) , 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Proz (GFP-tagged) - Mouse protein Z, vitamin K-dependent plasma glycoprotein (cDNA clone MGC:35708 IMAGE:5136392), 200 uL, >10^7 TU/mL

Lenti ORF particles, Proz (GFP-tagged) - Mouse protein Z, vitamin K-dependent plasma glycoprotein (cDNA clone MGC:35708 IMAGE:5136392), 200 uL, >10^7 TU/mL  
200 µl / €1,170.00
  OriGene Technologies, Inc.

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