Vitronectin antibody
Principal name
Vitronectin antibody
Alternative names for Vitronectin antibody
VTN, S-protein, V75, Serum-spreading factor
Ncbi ID
10090, NP_035837.1, 9606, NP_000629, NP_000629.3, NM_011707, NM_000638
Available reactivities
Available hosts
Available applications
Frozen Sections (C), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Functional assay (FN), Immunoprecipitation (IP), Immunocytochemistry/Immunofluorescence (ICC/IF), ELISA (detection) (E(detection)), Flow Cytometry (F), Paraffin Sections (P)
Background of Vitronectin antibody
Vitronectin is an abundant glycoprotein (~75 kDa), consisting of 459 amino acids. About one third of the protein molecular mass is composed of carbohydrates. Vitronectin is found in blood plasma and the extracellular matrix. Vitronectin is a multifunctional protein, since it promotes attachment and spreading of animal cells in vitro, it inhibits cytolysis by the complement C5b-9 complex, and it modulates antithrombin III-thrombin action in blood coagulation.
The protein consists of three domains: the N-terminal Somatomedin B domain (1-39), a central domain with hemopexin homology (131-342) and a C-terminal domain (347-459) also with hemopexin homology. The Somatomedin B domain binds to Plasminogen Activator Inhibitor-1 (PAI-1) and is responsible for PAI-1 stabilization. Furthermore, the Somatomedin B domain can also interact with the urokinase plasminogen activator receptor (uPAR). Vitronectin-uPAR interaction is required and sufficient to initiate downstream changes in cell morphology, migration and signal transduction. High plasma levels of both PAI-1 and uPAR have been shown to correlate with a negative prognosis for cancer patients. Additionally, vitronectin is a component of platelets and is as such involved in hemostasis. Amino acid 45-47 (RGD) are capable of binding to membrane bound integrins, which serve to anchor cells to the extracellular matrix.
Vitronectin in plasma is an inactive monomer form. In contrast, tissue vitronectin is an active multimeric form and is able to interact with various matrix ligands like proteoglycans and collagen. Mice with a genetic deletion of vitronectin show delayed wound healing, suggesting an important role of vitronectin in tissue remodeling after injury.
General readings
Chain D., et al. (1991) FEBS Lett. 285: 251-256.Cherny R C., et al. (1993) J Biol Chem. 268: 9725-9729.















Primary Antibodies
Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
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TA321171 | Vitronectin antibody |
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Anti-VTN Rabbit Polyclonal Antibody | |||||||
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Rabbit | IgG | Purified | Hu, Ms, Rt | E |
0.1 ml /
€335.00
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OriGene Technologies, Inc. | |||||||
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TA324937 | Vitronectin antibody |
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Rabbit polyclonal VTN Antibody (N-term) | |||||||
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Rabbit | IgG | Purified | Hu | F, P, WB |
0.4 ml /
€410.00
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OriGene Technologies, Inc. | |||||||
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TA344462 | Vitronectin antibody |
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Rabbit Polyclonal Anti-VTN Antibody - N-terminal region | |||||||
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Rabbit | IgG | Purified | Hu | WB |
50 µg /
€360.00
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|
OriGene Technologies, Inc. | |||||||
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TA346045 | Vitronectin antibody |
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Rabbit Polyclonal Anti-Vtn Antibody | |||||||
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Rabbit | IgG | Purified | Bov, Can, Eq, GP, Gt, Hu, Ms, Por, Rb, Rt, Ze | WB |
50 µg /
€360.00
|
|
OriGene Technologies, Inc. | |||||||
TA349592 | Vitronectin antibody |
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Rabbit Polyclonal Anti-VTN Antibody | |||||||
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Rabbit | IgG | Purified | Hu | E, P |
0.1 ml /
€335.00
|
|
OriGene Technologies, Inc. | |||||||
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AM01260PU-N | Vitronectin antibody |
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Mouse | IgG1 | BV2 | Purified | Hu | C, E, IP, WB |
0.1 mg /
€660.00
|
Acris Antibodies GmbH | |||||||
AM26283PU-N | Vitronectin antibody |
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Mouse | IgG1 | BV1 | Purified | Hu | E, ICC/IF, IP, WB |
0.1 mg /
€380.00
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Acris Antibodies GmbH | |||||||
AM32090PU-N | Vitronectin antibody |
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Mouse | IgG1 | BE10 | Ig Fraction | Hu | C, E, WB |
0.1 mg /
€450.00
|
Acris Antibodies GmbH | |||||||
AP00921PU-N | Vitronectin antibody |
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Rabbit | Purified | Hu | E, WB |
1 mg /
€760.00
|
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Acris Antibodies GmbH | |||||||
AP00922PU-N | Vitronectin antibody |
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Rabbit | Purified | Ms | C, E, WB |
1 mg /
€660.00
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Acris Antibodies GmbH | |||||||
AP14110PU-N | Vitronectin (C-term) antibody |
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Rabbit | Ig | Purified | Hu | WB |
0.4 ml /
€370.00
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Acris Antibodies GmbH | |||||||
BM767 | Vitronectin antibody |
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Mouse | IgG1 | 1.110 | Ascites | Hu | E, FN, WB |
25 µl /
€520.00
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Acris Antibodies GmbH | |||||||
BM2705 | Vitronectin antibody |
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Mouse | IgG2a | BDI215 | Purified | Hu | E, WB |
0.5 mg /
€920.00
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Acris Antibodies GmbH |
CRISPR
Catalog No. | Species | Donor Vector | |
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KN202929 | VTN - human gene knockout kit via CRISPR |
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Human | GFP-Puro |
1 kit /
€1,290.00
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OriGene Technologies, Inc. | |||
KN202929BN | VTN - human gene knockout kit via CRISPR |
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Human | mBFP-Neo |
1 kit /
€1,290.00
|
OriGene Technologies, Inc. | |||
KN202929LP | VTN - human gene knockout kit via CRISPR |
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Human | Luciferase-Puro |
1 kit /
€1,290.00
|
OriGene Technologies, Inc. | |||
KN202929RB | VTN - human gene knockout kit via CRISPR |
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Human | RFP-BSD |
1 kit /
€1,290.00
|
OriGene Technologies, Inc. | |||
KN319292 | Vtn - mouse gene knockout kit via CRISPR |
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Mouse | GFP-Puro |
1 kit /
€1,290.00
|
OriGene Technologies, Inc. | |||
KN319292BN | Vtn - mouse gene knockout kit via CRISPR |
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Mouse | mBFP-Neo |
1 kit /
€1,290.00
|
OriGene Technologies, Inc. | |||
KN319292LP | Vtn - mouse gene knockout kit via CRISPR |
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Mouse | Luciferase-Puro |
1 kit /
€1,290.00
|
OriGene Technologies, Inc. |