Vitronectin antibody

Principal name

Vitronectin antibody

Alternative names for Vitronectin antibody

VTN, S-protein, V75, Serum-spreading factor

SwissProt ID

P04004 (Human), P22458 (Rabit), P29788 (Mouse), P48819 (Pig)

Gene ID

7448 (VTN), 22370 (Vtn), 3744878 (IPR001986)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Sh (Sheep), Can (Canine), Eq (Equine), GP (Guinea Pig), Gt (Goat), Por (Porcine), Rb (Rabbit), Ze (Zebrafish)

Available hosts

Mouse, Sheep, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Frozen Sections (C), Paraffin Sections (P), Functional assay (FN), Immunodiffusion (ID), Immunoprecipitation (IP), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F), Dot blot (Dot), ELISA (detection) (E(detection))

Background of Vitronectin antibody

Vitronectin is an abundant glycoprotein (~75 kDa), consisting of 459 amino acids. About one third of the protein molecular mass is composed of carbohydrates. Vitronectin is found in blood plasma and the extracellular matrix. Vitronectin is a multifunctional protein, since it promotes attachment and spreading of animal cells in vitro, it inhibits cytolysis by the complement C5b-9 complex, and it modulates antithrombin III-thrombin action in blood coagulation.
The protein consists of three domains: the N-terminal Somatomedin B domain (1-39), a central domain with hemopexin homology (131-342) and a C-terminal domain (347-459) also with hemopexin homology. The Somatomedin B domain binds to Plasminogen Activator Inhibitor-1 (PAI-1) and is responsible for PAI-1 stabilization. Furthermore, the Somatomedin B domain can also interact with the urokinase plasminogen activator receptor (uPAR). Vitronectin-uPAR interaction is required and sufficient to initiate downstream changes in cell morphology, migration and signal transduction. High plasma levels of both PAI-1 and uPAR have been shown to correlate with a negative prognosis for cancer patients. Additionally, vitronectin is a component of platelets and is as such involved in hemostasis. Amino acid 45-47 (RGD) are capable of binding to membrane bound integrins, which serve to anchor cells to the extracellular matrix.
Vitronectin in plasma is an inactive monomer form. In contrast, tissue vitronectin is an active multimeric form and is able to interact with various matrix ligands like proteoglycans and collagen. Mice with a genetic deletion of vitronectin show delayed wound healing, suggesting an important role of vitronectin in tissue remodeling after injury.

General readings

General / background references:Yatohgo T et al. Novel purification of vitronectin from human plasma by heparin affinity chromatography. Cell Struct Funct 13:281-92 (1988). PubMed PMID: 2460263
Dahlback K et al. Immunohistochemical studies on vitronectin in elastic tissue disorders, cutaneous amyloidosis, lichen ruber planus and porphyria. Acta Derm Venereol 68:107-15 (1988). PubMed PMID: 2453988
Hayman EG et al. Serum spreading factor (vitronectin) is present at the cell surface and in tissues. Proc Natl Acad Sci U S A 80:4003-7 (1983). PubMed PMID: 6191326

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Vitronectin antibody

Predicted cell location: Cytoplasm. Positive control: Human liver and gastric cancer tissue. Recommended dilution: 1/100-300  The image on the left is immunohistochemistry of paraffin-embedded human liver cancer tissue using VTN) at dilution 1/100, on the right is treated with the synthetic peptide. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E
0.1 ml / €325.00
  OriGene Technologies, Inc.

Vitronectin antibody

Western blot analysis of VTN Antibody (N-term) (Cat. #TA324937) in NCI-H460 cell line lysates (35ug/lane). VTN (arrow) was detected using the purified Pab. Rabbit IgG Purified Hu F, P, WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

Vitronectin antibody

Host:Rabbit; Target Name:VTN; Sample Tissue:Human Adult Placenta; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

Vitronectin antibody

Host: Rabbit; Target Name: Vtn; Sample Tissue: Rat Kidney lysates; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Bov, Can, Eq, GP, Gt, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

Vitronectin antibody

ELISA: Vitronectin Antibody - Affinity Purified Rabbit IgG Purified Hu E
0.1 mg / €325.00
  OriGene Technologies, Inc.

Vitronectin antibody

Vitronectin Mouse IgG1 BV2 Purified Hu C, E, IP, WB
0.1 mg / €650.00
  Acris Antibodies GmbH

Vitronectin antibody

Vitronectin Mouse IgG1 BV1 Purified Hu E, ICC/IF, IP, WB
0.1 mg / €390.00
  Acris Antibodies GmbH

Vitronectin antibody

Vitronectin Mouse IgG1 BE10 Ig Fraction Hu C, E, WB
0.1 mg / €430.00
  Acris Antibodies GmbH

Vitronectin antibody

Vitronectin Rabbit Purified Hu E, WB
1 mg / €680.00
  Acris Antibodies GmbH

Vitronectin antibody

Vitronectin Rabbit Purified Ms C, E, WB
1 mg / €650.00
  Acris Antibodies GmbH

Vitronectin (C-term) antibody

Western blot analysis of VTN antibody (C-term) in NCI-H460 cell line lysates (35ug/lane). VTN (arrow) was detected using the purified Pab. Rabbit Ig Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Vitronectin antibody

Vitronectin Mouse IgG1 1.110 Ascites Hu E, FN, WB
25 µl / €510.00
  Acris Antibodies GmbH

Vitronectin antibody

Vitronectin Mouse IgG2a BDI215 Purified Hu E, WB
0.5 mg / €710.00
  Acris Antibodies GmbH

Vitronectin antibody

VTN MaxPab polyclonal antibody. Western Blot analysis of VTN expression in human liver. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

Vitronectin antibody

VTN MaxPab polyclonal antibody. Western Blot analysis of VTN expression in human liver. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

Vitronectin antibody

Vitronectin Rabbit Serum Hu E(detection), IP, WB
0.1 ml / €380.00
  Abnova Taiwan Corp.

Vitronectin antibody

Western Blot analysis of VTN expression in transfected 293T cell line (H00007448-T01) by VTN MaxPab polyclonal antibody.

Lane 1: VTN transfected lysate(54.30 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

Vitronectin antibody

Immunoblot analysis of human plasma protein. Lane 1 : VTN protein isolated from human plasma ( partial protein ) . Lane 2 : Human plasma ( 0.2 ul ) . Mouse IgG1 10E12 Hu E, WB
0.1 ml / €390.00
  Abnova Taiwan Corp.

Vitronectin antibody

Vitronectin Mouse IgG1 BE10 Hu C, WB
0.1 mg / €560.00
  Abnova Taiwan Corp.

Vitronectin antibody

Vitronectin Rabbit Ms C, E, WB
1 mg / €390.00
  Abnova Taiwan Corp.

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