VPRBP antibody

Principal name

VPRBP antibody

Alternative names for VPRBP antibody

HIV-1 Vpr-binding protein, DCAF1, KIAA0800, RIP, Vpr-interacting protein, DDB1- and CUL4-associated factor 1

SwissProt ID

Q80TR8 (Mouse), Q9Y4B6 (Human)

Gene ID

9730 (VPRBP)

Available reactivities

Can (Canine), Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts


Available applications

Enzyme Immunoassay (E), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Paraffin Sections (P), Western blot / Immunoblot (WB)

Background of VPRBP antibody

P55 is an extensively palmitoylated erythrocyte membrane protein, and a member of the MAGUK family. P55 also resists salt extraction, resulting in a high affinity for the plasma membrane. P55 contains a PDZ/DHR domain, a conserved SH-3 domain that appears to suppress tyrosine kinase activity of various oncoproteins, a 39-amino acid motif that binds to cytoskeletal protein 4.1R, and a guanylate kinase-like domain. Interaction with glycophorin C (GPC) and 4.1R suggests that p55 may play a role in the dynamic regulation in the erythrocyte membrane. In addition, p55 gene expression in vivo may be associated with a CpG island. P55 is constitutively expressed in K562 erythroleukemia cells during erythropoiesis and undergoes a 2-fold amplification after induction.

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